215868-81-8Relevant articles and documents
DEUTERIUM-MODIFIED TRIAZOLO-PYRIDAZINE DERIVATIVES AS GABA-A RECEPTOR MODULATORS
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Page/Page column 32, (2011/02/24)
This invention relates to deuterated substituted triazolo-pyridazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an αl-GABAA receptor antagonist or an α2- and/or an α3-GABAA receptor partial agonist.
NOVEL HERBICIDES
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Page/Page column 53, (2008/12/06)
The present invention relates to novel compounds of formula (I): wherein R1, R2, R3, R4, m, R5, R6, n and Y are as defined in claim 1; or N-oxides, salts and optical isomers thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to intermediates used in the preparation of compounds of formula (I), to herbicidal compositions comprising compounds of formula (I) and to methods of using compounds of formula (I) to control plants or to inhibit plant growth.
7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy) -3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: A functionally selective γ-aminobutyric acidA (GABAA) α2/α3- subtype selective agonist that exhibits potent anxiolyti
Carling, Robert W.,Madin, Andrew,Guiblin, Alec,Russell, Michael G. N.,Moore, Kevin W.,Mitchinson, Andrew,Sohal, Bindi,Pike, Andrew,Cook, Susan M.,Ragan, Ian C.,McKernan, Ruth M.,Quirk, Kathleen,Ferris, Pushpinder,Marshall, George,Thompson, Sally Ann,Wafford, Keith A.,Dawson, Gerard R.,Atack, John R.,Harrison, Timothy,Castro, José L.,Street, Leslie J.
, p. 7089 - 7092 (2007/10/03)
There is increasing evidence that compounds with selectivity for γ-aminobutyric acidA (GABAA) α2- and/or α3-subtypes may retain the desirable anxiolytic activity of nonselective benzodiazepines but possess an improved side effect pro
Substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom
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, (2008/06/13)
7-(1,1 -Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine, and pharmaceutically acceptable salts thereof are selective ligands for GABAAreceptors useful in the treatment of disorders of t
Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as GABA alpha 5 ligands
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, (2008/06/13)
Substituted 1,2,4-Triazolo[3,4-A]phthalazine derivatives are GABA Alpha 5 ligands and are represented by the formula