Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases
Vascular cell adhesion molecule-1 (VCAM-1) mediates recruitment of leukocytes to endothelial cells and is implicated in many inflammatory conditions. Since part of the signal transduction pathway that regulates the activation of VCAM-1 expression is redox
Meng, Charles Q.,Somers, Patricia K.,Hoong, Lee K.,Zheng, X. Sharon,Ye, Zhihong,Worsencroft, Kimberly J.,Simpson, Jacob E.,Hotema, Martha R.,Weingarten, M. David,MacDonald, Mathew L.,Hill, Russell R.,Marino, Elaine M.,Suen, Ki-Ling,Luchoomun, Jayraz,Kunsch, Charles,Landers, Laura K.,Stefanopoulos, Dimitria,Howard, Randy B.,Sundell, Cynthia L.,Saxena, Uday,Wasserman, Martin A.,Sikorski, James A.
p. 6420 - 6432
(2007/10/03)
Compounds and methods for treating transplant rejection
The use of compounds of the formula and pharmaceutically acceptable salts thereof, alone or in combination for the treatment of transplant rejection, wherein the substituents are further defined in the application.
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Page column 21
(2008/06/13)
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