2174-16-5

Basic information

• Product Name: TRIETHANOLAMINE SALICYLATE
• Synonyms: TROLAMINE SALICYLATE;SALICYLIC ACID, COMPOUND WITH TRIETHANOL-AMINE, 75 WT % SOLN IN 1,2-PROPANEDIOL;Benzoic acid, 2-hydroxy-, compd. with 2,2',2''-nitrilotris[ethanol];Benzoicacid,2-hydroxy-,compd.with2,2’,2’’-nitrilotris[ethanol](1:1);salicylicacid,compoundwithtriethanolaminesolution;Salicylicacidtriethanolaminesalt;tea-salicylate,triethanolaminesalicylate;TRIETHANOLAMINE SALICYLATE
• CAS NO: 2174-16-5
• Molecular Formula: C₆H₁₅NO₃*C₇H₆O₃
• Molecular Weight: 287.31
• EINECS: 218-531-3
• Mol File: 2174-16-5.mol

Chemical Properties

• Boiling Point: 335.4 °C at 760 mmHg
• Flash Point: 113 °C
• Appearance: pale yellow to amber crystalline solid
• Density: 1.209 g/mL at 25 °C
• Vapor Pressure: 8.38E-06mmHg at 25°C
• Refractive Index: n20/D 1.509
• BRN: 7451205
• CAS DataBase Reference: TRIETHANOLAMINE SALICYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIETHANOLAMINE SALICYLATE(2174-16-5)
• EPA Substance Registry System: TRIETHANOLAMINE SALICYLATE(2174-16-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• Hazardous Substances Data: 2174-16-5(Hazardous Substances Data)

Usage

Uses

Used in Surface Active Agents:
Triethanolamine Salicylate is used as an intermediate for the production of surface active agents, which are essential in the creation of textile specialties, waxes, polishes, herbicides, petroleum demulsifiers, toilet goods, cement additives, and cutting oils.
Used in Emulsions:
It is utilized in making emulsions with mineral and vegetable oils, paraffin, and waxes, which are crucial in various industries for different applications.
Used as a Solvent:
Triethanolamine Salicylate serves as a solvent for casein, shellac, and dyes, playing a vital role in the manufacturing process of these substances.
Used in Synthetic Resins:
It is employed in the production of synthetic resins, which are widely used in the plastics and coatings industries.
Used in Wood and Paper Treatment:
The compound is used to increase the penetration of organic liquids into wood and paper, enhancing their properties and performance.
Used in the Textile Industry:
Triethanolamine Salicylate is used in the production of lubricants for the textile industry, improving the quality and efficiency of textile manufacturing processes.
Used as a Pharmaceutical Aid:
It functions as an alkalizer and is recognized as a pharmaceutic aid, contributing to the development and formulation of various medications.
Used in Sunscreen Products:
TEA-salicylate is a chemical UVB absorber, one of the 21 FDA-approved sunscreen chemicals with an approved usage level of 5 to 12 percent. It is used as a preservative in the formulation of sunscreen products, providing protection against harmful UV radiation.
Used in the Cosmetics Industry:
Formulators may also use Triethanolamine Salicylate as a preservative in the cosmetics industry, ensuring the stability and longevity of various cosmetic products.

InChI:InChI=1/C7H6O3.C6H15NO3/c8-6-4-2-1-3-5(6)7(9)10;8-4-1-7(2-5-9)3-6-10/h1-4,8H,(H,9,10);8-10H,1-6H2

Synthetic route

triethanolamine (102-71-6) + aspirin (50-78-2) → triethanolamine salicylate (2174-16-5)

Conditions	Yield
With methanol for 1h; Reflux;	99%

triethanolamine (102-71-6) + salicylic acid (69-72-7) → triethanolamine salicylate (2174-16-5)

Conditions	Yield
In methanol for 1h; Reflux;	99%
In methanol at 60 - 65℃;	99%
In ethanol

Upstream product

• 102-71-6 triethanolamine 
• 69-72-7 salicylic acid 
• 50-78-2 aspirin 

Relevant articles and documents

Triethanolammonium salts of biologically active carboxylic acids

Triethanolammonium salts (protatranes) of biologically active carboxylic acids (nicotinic, cinnamic, benzoic, salicylic, oxalic, malonic, succinic, malic, citric) were synthesized in yields exceeding 90%. The structure of the synthesized compounds was studied by IR spectroscopy and X-ray diffraction analysis.

Triethanolammonium salicylate — Protic alkanolammonium ionic liquid

Triethanolammonium salicylate was synthesized, characterized by IR and NMR spectroscopy, elemrntal analysis, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The structure was established, and cation-anion interactions were investigated by X-ray diffraction analysis. It was found that exchange reaction occurs at triethanolammonium salts interaction with silver (I) nitrate, and the product structure was established by X-ray diffraction analysis. The influence of triethanolammonium salicylate solution on the growth properties of the fungus Rhizopus oryzae was studied.

Biological Activity of Protic Ionic Liquids Based on Tris(2-hydroxyethyl)ammonium Salts and the Crystal Structure of Tris(2-hydroxyethyl)ammonium Malate

Abstract: The antimicrobial and growth-stimulating activities of nine protic ionic liquids (PILs)—tris(2-hydroxyethyl)ammonium salts (protatranes) of cinnamic, benzoic, salicylic, oxalic, malonic, succinic, malic and citric acids—were investigated for the first time. It was found that tris(2-hydroxyethyl)ammonium salts of cinnamic, benzoic and malonic acids have a positive impact on seeds germination and growth characteristics of garden cress (Lepidium sativum L.) sprouts. All the investigated PILs exhibited selective activity against Staphylococcus aureus bacteria. PILs based on tris(2-hydroxyethyl)ammonium malate with the melting point of 41°C were isolated as crystals to perform a comparative study of the crystal structure by single-crystal X-ray diffraction. In contrast to cations in tris(2-hydroxyethyl)ammonium succinate, cations in malate have a tricyclic endo conformation that is most typical of tris(2-hydroxyethyl)ammonium salts.

The hydrophilic ionic liquid at room temperature and its use

PROBLEM TO BE SOLVED: To provide a novel ionic liquid that is liquid at a room temperature and is hydrophilic, particularly water-soluble, and use thereof.SOLUTION: This invention provides a hydrophilic room-temperature ionic liquid including a cation and an anion, the cation being a quaternary ammonium cation of the formula (I), and the anion being a carboxylate anion, where R represents a 1-5C straight-chain or branched-chain alkylene group, and n represents an integer of 1-3.

Photoprotective compositions comprising sulfonic/hydrophobic amphiphilic polymers

Photoprotective cosmetic/dermatological compositions well suited for the UV-photoprotection of human skin and/or hair, comprise (a) at least one organic UV-screening agent and (b) an SPF-improving amount of at least one amphiphilic polymerizate of at least one ethylenically unsaturated monomer which comprises a sulfonic group, whether in the free acid or in partially or totally neutralized state, and which amphiphilic polymerizate also comprises at least one hydrophobic moiety.

Structure-improving hair care agents

There are provided topical hair care compositions for improving the structure and strength of hair keratin and the fastness to washing of hair colors which contain vitamin B6 derivatives of the formula (1) or physiologically compatible salts thereof.