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Product FOB Price Min.Order Supply Ability Supplier
CHemwill -- Acetyl Salicylic Acid BP/USP/EP/JP/ DC90/100Acetylsalicylic acid
Cas No: 50-78-2
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1-500 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
50-78-2 Aspirin
Cas No: 50-78-2
No Data 1 Kilogram 1000 Kilogram/Month Shaanxi WuZhiYuan Biological Technology Co.,Ltd Contact Supplier
Aspirin
Cas No: 50-78-2
USD $ 4393.0-4393.0 / Metric Ton 1 Metric Ton 500 Metric Ton/Month Wuhan ZeShanCheng Biomedical Technology Co., Ltd. Contact Supplier
High purity 99% Acetylsalicylic acid factory in stock
Cas No: 50-78-2
No Data 1 Kilogram 1 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
Aspirin
Cas No: 50-78-2
No Data 1 Kilogram 100 Metric Ton/Month EnBridge PharmTech Co., Ltd. Contact Supplier
Aspirin
Cas No: 50-78-2
USD $ 2500.0-3000.0 / Kilogram 100 Kilogram 1000 Metric Ton/Month GUANGZHOU MEDCAN PHARMATECH LTD Contact Supplier
Acetylsalicylic acid
Cas No: 50-78-2
No Data No Data No Data SJZ THLD IMP & EXP CO LTD Contact Supplier
Acetylsalicylic acid Manufacturer/High quality/Best price/In stock
Cas No: 50-78-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
50-78-2 Aspirin
Cas No: 50-78-2
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Acetylsalicylic acid / Aspirin CAS NO.50-78-2
Cas No: 50-78-2
No Data 1 Kilogram 500~1000 Kilogram/Month Hubei Jusheng Technology Co., Ltd., Contact Supplier

50-78-2 Usage

Production method

Acetylation of salicylic acid: add acetic anhydride (feeding ratio is 0.7889 times of the total salicylic acid) in reaction vessel, and then add two thirds of salicylic acid, stir it and temperature rises. React 40-60min in 81-82℃. Cool it to 81-82 ℃ and keep the temperature for 2h. When free salicylic acid is qualified, cool it to 13 ℃, precipitation crystallization, rejection filter, dry it in 65-70℃ air flow, then we get acetylsalicylic acid.

How Aspirin is used in Ischemic Stroke therapy

In the therapy of Ischemic Stroke, 50 to 325 mg/day started between 24 and 48 hours after completion of alteplase has also been shown to reduce long-term death and disability.
Aspirin, clopidogrel, and extended-release dipyridamole plus aspirin are all considered first-line antiplatelet agents. The combination of aspirin and clopidogrel can only be recommended in patients with ischemic stroke and a recent history of myocardial infarction or coronary stent placement and then only with ultra-low-dose aspirin to minimize bleeding risk.

What’s acetylsalicylic acid?

Acetylsalicylic acid, also known as aspirin, is an analgesic-antipyretic medicine made by salicylic acid interacting with acetic anhydride. It is a white crystalline powder, odorless, stable in dry air. It will be slowly hydrolyzed to be salicylic acid and acetic acid in moist air, and aqueous solution has acidic reaction. Slightly soluble in water, soluble in ethanol, ethyl ether, chloroform, sodium hydroxide solution and sodium carbonate solution. Acetylsalicylic acid has antipyretic analgesic, anti-inflammatory and anti-rheumatism effect, that’s why it is often used for fever, headache, muscle pain, neuralgia, rheumatic fever, acute rheumatic arthritis, gout, etc.; also it has antiplatelet aggregation effect, and can be used for prevention of arterial thrombosis, atherosclerosis, transient cerebral ischemia and myocardial infarction; in addition, acetylsalicylic acid also can be used in the treatment of biliary tract roundworm disease and athlete's foot.
Pharmacological actions
Acetylsalicylic acid is one of the traditional antipyretic analgesics, as well as the role of platelet aggregation. Acetylsalicylic acid in the body has the characteristics of the antithrombotic, can reduce the formation of obstructive blood clots in surrounding arteries, and inhibit release of platelet response and endogenous ADP, 5-HT, etc., therefore to inhibit second phase other than the first phase of platelet aggregation. The mechanism of action of acetylsalicylic acid is to make platelets cyclooxygenase acetylation, thus inhibiting the formation of ring peroxide, and TXA2 formation is also reduced as well. At the mean time make the platelet membrane protein acetylation, and inhibit platelet membrane enzyme, which helps to inhibit platelet function. As the cyclooxygenase is inhibited, it impacts blood vessel wall synthesized to be PGI2, the platelet TXA2 synthetic enzymes also to be inhibited; so it would impact formation of both TXA2 and PGI2 when it is large doses. Suitable for ischemic heart disease, after percutaneous transluminal coronary angioplasty or coronary artery bypass grafting, prevent transient ischemic stroke, myocardial infarction and reduce the incidence of arrhythmia.
The above information is edited by the Chemicalbook He Liao Pu.

General Description

Odorless white crystals or crystalline powder with a slightly bitter taste.

Uses

1.Acetylsalicylic acid is the raw material for rodenticide intermediates 4-hydroxycoumarin.
2.Used to make outdoor structural members and equipment parts exposed in highlights, such as the automobile body, agricultural machinery parts, meters and electric lamps, road marking, etc.
3.It is the earliest applied, the most popular and the most common antipyretic analgesics anti-rheumatism medicine, has aspects of pharmacological effects as antipyretic-analgesic and anti-inflammatory, anti-platelet aggregation and works quickly and effectively. Overdosage can be easily diagnosed and treated, with rare allergic reactions. Often used to cold fever, headache, neuralgia, joint ache, muscle pain, rheumatic fever, acute wet sex arthritis, rheumatoid arthritis and toothache, etc. Listed in National Essential Medicine List. Acetylsalicylic acid also works as an intermediate of other medicines.

Uses

Analgesic; antipyretic; anti-inflammatory; antithrombotic

Air & Water Reactions

Slowly hydrolyzes in moist air. Has been involved in dust cloud explosions. Water insoluble. Solution in water is acid to methyl red indicator.

Category

Toxic substance

Fire extinguishing agent

Water fog, foam, carbon dioxide, sandy soil.

Chemical Properties

White Solid

Handling and storage characteristics

Warehouse needs to be ventiIative and dry with low temperature; separate it from oxidant and food additives.

Toxicity grading

High toxic

Uses

Axepim Cephalosporin antibiotic

Fire Hazard

Acetylsalicylic acid is combustible.

Definition

ChEBI: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity.

Purification Methods

Crystallise aspirin twice from toluene, wash it with cyclohexane and dry it at 60o under vacuum for several hours [Davis & Hetzer J Res Nat Bur Stand 60 569 1958]. It has been recrystallised from isopropanol and from diethyl ether/pet ether (b 40-60o). It crystallises from EtOH (m 143-144o), *C6H6 (m 143o), hexane (m 115o and 128o), octane (m 121o), and has m 110o after sublimation. It has pK2 6 3.69(H2O), 4.15(20% aqueous EtOH), 4.47(30% aqueous EtOH) and 4.94(40% aqueous EtOH). It is an analgesic. [Beilstein 10 H 67, 10 II 41, 10 III 102, 10 IV 138.]

Uses

antifungal

Reactivity Profile

The active ingredient in common aspirin. Incompatible with oxidizers and strong acids. Also incompatible with strong bases. May react with water or nucleophiles (e.g. amines and hydroxy groups). May also react with acetanilide, amidopyrine, phenazone, hexamine, iron salts, phenobarbitone sodium, quinine salts, potassium and sodium iodides, alkali hydroxides, carbonates, stearates and paracetanol.

Chemical property

This product is a white crystalline, with melting point 138~140 ℃, insoluble in water, soluble in alcohol, ether, etc.

Flammable hazardous characteristics

Flammable in fire; irritant gas would be decomposed out when heated.

Acute toxicity

Oral-rat LD50: 200 mg/kg; Oral-mice LD50: 250 mg/kg

Occupational standard

TWA 5 mg/m3
InChI:InChI=1/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)/p-1

50-78-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (A3160)  Acetylsalicylicacid  analytical standard 50-78-2 A3160-5X1VL 4,699.89CNY Detail
Sigma (A3160)  Acetylsalicylicacid  analytical standard 50-78-2 A3160-1VL 1,173.51CNY Detail
USP (1044006)  Aspirin  United States Pharmacopeia (USP) Reference Standard 50-78-2 1044006-500MG 4,662.45CNY Detail
Sigma-Aldrich (Y0001460)  Acetylsalicylic acid for peak identification  European Pharmacopoeia (EP) Reference Standard 50-78-2 Y0001460 1,880.19CNY Detail
Sigma-Aldrich (A0200000)  Acetylsalicylicacid  European Pharmacopoeia (EP) Reference Standard 50-78-2 A0200000 1,880.19CNY Detail
Sigma-Aldrich (PHR1003)  Aspirin (Acetyl Salicylic Acid)  pharmaceutical secondary standard; traceable to USP, PhEur and BP 50-78-2 PHR1003-1G 732.19CNY Detail
Alfa Aesar (A12488)  O-Acetylsalicylic acid, 99%    50-78-2 2500g 733.0CNY Detail
Alfa Aesar (A12488)  O-Acetylsalicylic acid, 99%    50-78-2 500g 275.0CNY Detail
Alfa Aesar (A12488)  O-Acetylsalicylic acid, 99%    50-78-2 100g 99.0CNY Detail
TCI America (A2262)  Acetylsalicylic Acid  >98.0%(GC)(T) 50-78-2 500g 295.00CNY Detail
TCI America (A2262)  Acetylsalicylic Acid  >98.0%(GC)(T) 50-78-2 25g 98.00CNY Detail

50-78-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name acetylsalicylic acid

1.2 Other means of identification

Product number -
Other names 2-Acetoxybenzoic acid,O-Acetylsalicylic acid,ASA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50-78-2 SDS

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