- Study of polymorphic behaviour of 2,2'-dichloro benzil using dynamic thermal and X-ray diffraction technique
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2,2’-Dichloro benzil (1) was synthesized and its two polymorphic forms were obtained by recrystallization from the solvents acetone/ chloroform and ethanol. The polymorphism present in the compound was confirmed by combined results of differential scannin
- Nithya,Sudha,Kanakam, Charles C.
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- Catalyst-Free and Transition-Metal-Free Approach to 1,2-Diketones via Aerobic Alkyne Oxidation
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A catalyst-free and transition-metal-free method for the synthesis of 1,2-diketones from aerobic alkyne oxidation was reported. The oxidation of various internal alkynes, especially more challenging aryl-alkyl acetylenes, proceeded smoothly with inexpensive, easily handled, and commercially available potassium persulfate and an ambient air balloon, achieving the corresponding 1,2-diketones with up to 85% yields. Meanwhile, mechanistic studies indicated a radical process, and the two oxygen atoms in the 1,2-diketons were most likely from persulfate salts and molecular oxygen, respectively, rather than water.
- Shen, Duyi,Wang, Hongyan,Zheng, Yanan,Zhu, Xinjing,Gong, Peiwei,Wang, Bin,You, Jinmao,Zhao, Yulei,Chao, Mianran
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p. 5354 - 5361
(2021/05/05)
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- Hexaaryl bis-imidazole photoinitiator and application thereof
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The invention discloses a hexaaryl bis-imidazole photoinitiator. The molar ratio of a red shift substituent group in all substitutable sites of the hexaaryl bis-imidazole photoinitiator is 6-16%. Whenthe photoinitiator is applied to a photosensitive resin composition, the photoinitiator is moderate in sensitivity, good in solubility and excellent in resolution ratio and developability, inverted trapezoids cannot appear during development, the photoinitiator has good hydrophilicity, the amount of sludge in a developing solution during recycling can be remarkably reduced, and the developing solution can be repeatedly and effectively used for multiple times. The invention also provides a photosensitive resin composition containing the photoinitiator, and an application of the composition.
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Paragraph 0167-0170
(2020/10/16)
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- Ruthenium/dendrimer complex immobilized on silica-functionalized magnetite nanoparticles catalyzed oxidation of stilbenes to benzil derivatives at room temperature
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A new ruthenium/dendrimer complex stabilized on the surface of silica-functionalized nano-magnetite was fabricated and well characterized. The nano-catalyst showed good activity in the synthesis of benzil derivatives via the oxidation of stilbenes with high turnover frequency (TOF) at room temperature. Moreover, the catalyst could also be reused up to fifteen times without any loss of its activity.
- Ghanaatzadeh, Niloofar,Hashemi, Hajar,Moghadam, Majid,Niknam, Khodabakhsh,Saberi, Dariush
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- NaBrO3/bmim[HSO4]: a versatile system for the selective oxidation of 1,2-diols, α-hydroxyketones, and alcohols
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Abstract: Sodium bromate with bmim[HSO4] has been found to be an excellent oxidizing agent in aqueous medium. NaBrO3:bmim[HSO4] oxidized 1,2-diols, α-hydroxyketones, and alcohols to the corresponding carbonyl compounds in excellent yields. This method offers advantages such as low cost reagents, aqueous reaction conditions, moderate temperatures and short reaction times and hence environmentally benign reaction. Moreover, the ionic liquid bmim[HSO4] could be recycled for at least three times without loss of significant activity. Graphical abstract: [Figure not available: see fulltext.]
- Khurana, Jitender M.,Lumb, Anshika,Chaudhary, Ankita
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p. 381 - 386
(2017/02/10)
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- Synthesis and biological evaluation of novel 1,2,4-triazine derivatives bearing carbazole moiety as potent α-glucosidase inhibitors
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A new series of 1,2,4-triazine derivatives bearing carbazole moiety 7a-7p were designed, synthesized, and evaluated for their α-glucosidase inhibitory activity. The majority of the screened compounds displayed potent α-glucosidase inhibitory activity, with IC50 values in the range of 4.27 ± 0.07-47.75 ± 0.25 μM as compared to the standard drug acarbose. Among the series, compound 7k represented the most potent α-glucosidase inhibitory activity with IC50 values of 4.27 ± 0.07 μM. Kinetic analysis revealed that compound 7k is a non-competitive inhibitor with a Ki of 4.43 μM. Furthermore, the binding interactions of compound 7k with α-glucosidase was confirmed through molecular docking. This study showed these 1,2,4-triazine derivatives bearing carbazole moiety as a new class of α-glucosidase inhibitors.
- Wang, Guangcheng,Wang, Jing,He, Dianxiong,Li, Xin,Li, Juan,Peng, Zhiyun
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p. 2806 - 2809
(2016/06/09)
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- Lanthanum triflate-catalyzed rapid oxidation of secondary alcohols using hydrogen peroxide urea adduct (UHP) in ionic liquid
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A convenient and efficient protocol for the oxidation of secondary hydroxyl group to ketone using hydrogen peroxide-urea adduct and catalytic (CF 3SO3)3La in ionic liquid has been developed. A number of 1,2-diols, -hydroxyketones, and other aromatic and aliphatic secondary alcohols have been successfully oxidized to the corresponding ketones using this protocol in good yields and short reaction times. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
- Saluja, Pooja,Magoo, Devanshi,Khurana, Jitender M.
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supporting information
p. 800 - 806
(2014/03/21)
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- Synthesis of ferrocene derivatives with planar chirality via palladium-catalyzed enantioselective C-H bond activation
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The first catalytic and enantioselective C-H direct acylation of ferrocene derivatives has been developed. A series of 2-acyl-1-dimethylaminomethylferrocenes with planar chirality were provided under highly efficient and concise one-pot conditions with up to 85% yield and 98% ee. The products obtained could be easily converted to various chiral ligands via diverse transformations.
- Pi, Chao,Cui, Xiuling,Liu, Xiuyan,Guo, Mengxing,Zhang, Hanyu,Wu, Yangjie
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supporting information
p. 5164 - 5167
(2014/12/11)
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- Unexpected transformation of aldehydes into benzoins with Copper(I)/Samarium
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The reductive coupling of aldehydes to afford pinacolic alcohols using all kinds of reducing agents involving samarium is well known. In this report, however, treatment of aromatic aldehydes with Cu(I)/Sm system produces benoins and/or benzils in good yields. A possible mechanism is proposed where Cu(I) not only activates the Sm metal but also promotes the dehydrogenation of the intermediates, during which a Cu(III) species may be involved. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
- Liu, Yongjun,Wang, Hui,Fu, Yulong,Qi, Yan,Yang, Kuiwei
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p. 259 - 266
(2013/12/04)
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- CuI-catalyzed and air promoted oxidative cyclization for one-pot synthesis of polyarylated oxazoles
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A facile CuI-catalyzed and air promoted oxidative cyclization was developed for the synthesis of polyarylated oxazoles. By virtue of this method, a variety of arylated oxazoles could be easily synthesized from readily available starting materials at room temperature in air. The Royal Society of Chemistry 2013.
- Hu, Ping,Wang, Qiang,Yan, Yizhe,Zhang, Shuai,Zhang, Baiqun,Wang, Zhiyong
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supporting information
p. 4304 - 4307
(2013/08/23)
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- N-heterocyclic carbene catalyzed one-pot synthesis of 2,3- diarylquinoxalines
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A one-pot efficient and facile protocol for the direct synthesis of quinoxaline derivatives via tandem N-heterocyclic carbene (NHC)-catalyzed umpolung of aldehydes/oxidation of the benzoins to benzils/condensation of benzils with benzene-1,2-diamines has been developed. Georg Thieme Verlag Stuttgart New York.
- Lin, Yang,Lei, Xiaoli,Yang, Qin,Yuan, Jiangjun,Ding, Qiuping,Xu, Jingshi,Peng, Yiyuan
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p. 2699 - 2706
(2012/11/13)
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- Oxidation of hydrobenzoins to benzils by ammonium chlorochromate/ montmorillonite K-10 under ultrasound irradiation
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The oxidation of hydrobenzoins to the corresponding benzils was carried out in excellent yield by ammonium chlorochromate (ACC) supported on montmorillonite K10 in CH2Cl2 at room temperature under ultrasound irradiation.
- Li, Ji-Tai,Sun, Xue-Li
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experimental part
p. 4321 - 4327
(2010/04/26)
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- Ruthenium catalyzed oxidation of 1,2-diols to 1,2-diketones using bromamine-T as an oxidizing agent
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A variety of 1,2-diols were selectively oxidized to their corresponding 1,2-diketones with bromamine-T using RuCl3 · xH2O as catalyst in alkaline acetonitrile/ water (1:1) medium. The reaction was pH dependent (pH 8.4), and at higher pH the rate of the reaction decreased significantly. Copyright Taylor & Francis, Inc.
- Jain, Suman L.,Sharma, Vishal B.,Sain, Bir
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p. 465 - 469
(2007/10/03)
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- Methyltrioxorhenium catalyzed oxidation of 1,2-diols to 1,2-diketones using hydrogen peroxide as oxidant
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A variety of 1,2-diols were oxidized selectively to the corresponding 1,2-diketones by the dropwise addition of 30% aqueous hydrogen peroxide using methyltrioxorhenium as catalyst.
- Jain, Suman L.,Sharma, Vishal B.,Sain, Bir
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p. 1233 - 1235
(2007/10/03)
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- A novel method of synthesis of 1,2-diketones from 1,2-diols using N-bromosuccinimide
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A simple and convenient procedure is reported for the synthesis of benzils and aliphatic 1,2-diketones of cyclic and open chain compounds from corresponding hydrobenzoins and 1,2-diols by refluxing with N-bromosuccinimide in carbon tetrachloride in presence or absence of pyridine.
- Khurana, Jitender M.,Kandpal, Bhaskar M.
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p. 4909 - 4912
(2007/10/03)
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- Indium-mediated reductive coupling of acyl cyanides: A convenient synthesis of 1,2-diketones
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The indium-mediated reductive coupling of acyl cyanides afforded the corresponding 1,2-diketones in moderate to good yields under neutral and mild conditions. (C) 2000 Elsevier Science Ltd.
- Baek,Lee,Yoo,Ko,Kim,Kim
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p. 8097 - 8099
(2007/10/03)
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