21854-95-5

Usage

Uses

Used in Pharmaceutical Industry:
2,2'-Dichlorobenzil is used as a key intermediate for the synthesis of substituted benzils and analogs with biological and pharmacological properties. These compounds have potential applications in the development of new drugs and therapies, particularly in the treatment of various diseases and medical conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,2'-dichlorobenzil is utilized as a starting material for the creation of a wide range of chemical compounds. Its unique structure and functional groups make it a versatile building block for the synthesis of various organic molecules with diverse applications.
Used in Research and Development:
2,2'-Dichlorobenzil is also employed in research and development settings, where it is used to study the structure-activity relationships of benzil derivatives and their analogs. This information is crucial for understanding the biological and pharmacological properties of these compounds and can lead to the discovery of new drugs and therapeutic agents.

Upstream product

• 35190-16-0 2,2'-dichlorobenzoin 
• 89-98-5 2-chloro-benzaldehyde 
• 35022-42-5 2-chlorobenzoyl cyanide 
• 100-52-7 benzaldehyde 
• 5293-77-6 1-chloro-2-(2'-chlorophenylethynyl)-benzene 
• 24133-53-7 1,2-bis(2-chlorophenyl)-1,2-ethanediol 

Downstream Products

• 92030-41-6 2,2'-dichloro-5,5'-dinitro-benzil 
• 3152-12-3 α-(hydroxy)-2-chloro-α-(2-chlorophenyl)benzeneacetic acid 
• 68240-87-9 4-(2-chlorophenyl)-5-(2'-chlorophenyl)-imidazole 
• 854884-77-8 3,4-bis-(2-chloro-phenyl)-2,5-diphenyl-cyclopentadienone 
• 90833-52-6 7-hydroxy-2,3-bis(2-chlorophenyl)-6-quinoxalinecarboxylic acid 
• 35190-16-0 2,2'-dichlorobenzoin 
• 92405-79-3 5,6-bis(o-chlorophenyl)-2,3-dihydropyrazine 
• 90833-51-5 2,3-bis(2-chlorophenyl)-6-quinoxalinecarboxylic acid 
• 90833-23-1 2,3-bis-(2-chlorophenyl)-5-quinoxalinecarboxylic acid 
• 63818-43-9 2,2'-Dichlorbenzyl-dimethylmonoketal 
• 610-96-8 methyl chlorobenzoate 
• 62497-25-0 3,4-bis(2-chlorophenyl)thiophene-2,5-dicarboxylic acid 
• 548760-14-1 5,6-bis(2-chlorophenyl)-pyrazine-2-carboxylic acid 

Relevant academic research and scientific papers

Study of polymorphic behaviour of 2,2'-dichloro benzil using dynamic thermal and X-ray diffraction technique

2,2’-Dichloro benzil (1) was synthesized and its two polymorphic forms were obtained by recrystallization from the solvents acetone/ chloroform and ethanol. The polymorphism present in the compound was confirmed by combined results of differential scannin

Catalyst-Free and Transition-Metal-Free Approach to 1,2-Diketones via Aerobic Alkyne Oxidation

A catalyst-free and transition-metal-free method for the synthesis of 1,2-diketones from aerobic alkyne oxidation was reported. The oxidation of various internal alkynes, especially more challenging aryl-alkyl acetylenes, proceeded smoothly with inexpensive, easily handled, and commercially available potassium persulfate and an ambient air balloon, achieving the corresponding 1,2-diketones with up to 85% yields. Meanwhile, mechanistic studies indicated a radical process, and the two oxygen atoms in the 1,2-diketons were most likely from persulfate salts and molecular oxygen, respectively, rather than water.

Hexaaryl bis-imidazole photoinitiator and application thereof

The invention discloses a hexaaryl bis-imidazole photoinitiator. The molar ratio of a red shift substituent group in all substitutable sites of the hexaaryl bis-imidazole photoinitiator is 6-16%. Whenthe photoinitiator is applied to a photosensitive resin composition, the photoinitiator is moderate in sensitivity, good in solubility and excellent in resolution ratio and developability, inverted trapezoids cannot appear during development, the photoinitiator has good hydrophilicity, the amount of sludge in a developing solution during recycling can be remarkably reduced, and the developing solution can be repeatedly and effectively used for multiple times. The invention also provides a photosensitive resin composition containing the photoinitiator, and an application of the composition.

Ruthenium/dendrimer complex immobilized on silica-functionalized magnetite nanoparticles catalyzed oxidation of stilbenes to benzil derivatives at room temperature

A new ruthenium/dendrimer complex stabilized on the surface of silica-functionalized nano-magnetite was fabricated and well characterized. The nano-catalyst showed good activity in the synthesis of benzil derivatives via the oxidation of stilbenes with high turnover frequency (TOF) at room temperature. Moreover, the catalyst could also be reused up to fifteen times without any loss of its activity.

NaBrO3/bmim[HSO4]: a versatile system for the selective oxidation of 1,2-diols, α-hydroxyketones, and alcohols

Abstract: Sodium bromate with bmim[HSO4] has been found to be an excellent oxidizing agent in aqueous medium. NaBrO3:bmim[HSO4] oxidized 1,2-diols, α-hydroxyketones, and alcohols to the corresponding carbonyl compounds in excellent yields. This method offers advantages such as low cost reagents, aqueous reaction conditions, moderate temperatures and short reaction times and hence environmentally benign reaction. Moreover, the ionic liquid bmim[HSO4] could be recycled for at least three times without loss of significant activity. Graphical abstract: [Figure not available: see fulltext.]

Synthesis and biological evaluation of novel 1,2,4-triazine derivatives bearing carbazole moiety as potent α-glucosidase inhibitors

A new series of 1,2,4-triazine derivatives bearing carbazole moiety 7a-7p were designed, synthesized, and evaluated for their α-glucosidase inhibitory activity. The majority of the screened compounds displayed potent α-glucosidase inhibitory activity, with IC50 values in the range of 4.27 ± 0.07-47.75 ± 0.25 μM as compared to the standard drug acarbose. Among the series, compound 7k represented the most potent α-glucosidase inhibitory activity with IC50 values of 4.27 ± 0.07 μM. Kinetic analysis revealed that compound 7k is a non-competitive inhibitor with a Ki of 4.43 μM. Furthermore, the binding interactions of compound 7k with α-glucosidase was confirmed through molecular docking. This study showed these 1,2,4-triazine derivatives bearing carbazole moiety as a new class of α-glucosidase inhibitors.

Lanthanum triflate-catalyzed rapid oxidation of secondary alcohols using hydrogen peroxide urea adduct (UHP) in ionic liquid

A convenient and efficient protocol for the oxidation of secondary hydroxyl group to ketone using hydrogen peroxide-urea adduct and catalytic (CF 3SO3)3La in ionic liquid has been developed. A number of 1,2-diols, -hydroxyketones, and other aromatic and aliphatic secondary alcohols have been successfully oxidized to the corresponding ketones using this protocol in good yields and short reaction times. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Synthesis of ferrocene derivatives with planar chirality via palladium-catalyzed enantioselective C-H bond activation

The first catalytic and enantioselective C-H direct acylation of ferrocene derivatives has been developed. A series of 2-acyl-1-dimethylaminomethylferrocenes with planar chirality were provided under highly efficient and concise one-pot conditions with up to 85% yield and 98% ee. The products obtained could be easily converted to various chiral ligands via diverse transformations.

Unexpected transformation of aldehydes into benzoins with Copper(I)/Samarium

The reductive coupling of aldehydes to afford pinacolic alcohols using all kinds of reducing agents involving samarium is well known. In this report, however, treatment of aromatic aldehydes with Cu(I)/Sm system produces benoins and/or benzils in good yields. A possible mechanism is proposed where Cu(I) not only activates the Sm metal but also promotes the dehydrogenation of the intermediates, during which a Cu(III) species may be involved. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]