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2192-06-5

2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE, commonly known as thioacetazone hydrochloride, is a pharmaceutical chemical compound derived from thiosemicarbazide. It has been recognized for its potential antimicrobial and antitubercular properties, making it a significant player in the treatment of tuberculosis, especially against drug-resistant strains. Thioacetazone hydrochloride is believed to function by inhibiting the growth of mycobacteria, although the exact mechanism of its action remains not fully elucidated. It is typically administered orally and is noted for its favorable safety profile, with the most common side effects being gastrointestinal discomfort and skin rash.

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  • 2192-06-5 Structure

  • Basic information

    1. Product Name: 2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE
    2. Synonyms: BUTTPARK 148\07-35;2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE;2-AMINOTHIAZOLE-4-ONE HYDROCHLORIDE;2-AMINOTHIAZOLINONE HCL;2-Amino-4,5-dihydro-1,3-thiazol-4-oneHCl;2-Amino-4,5-dihydro-1,3-thiazol-4-one hydrochloride, tech;2-AMINOTHIAZOLINONE HCI;2-Amino-1,3-thiazol-4(5H)-one hydrochloride
    3. CAS NO:2192-06-5
    4. Molecular Formula: C3H4N2OS*ClH
    5. Molecular Weight: 152.6
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2192-06-5.mol

  • Chemical Properties

    1. Melting Point: >350 °C
    2. Boiling Point: 253.5°Cat760mmHg
    3. Flash Point: 107.1°C
    4. Appearance: /
    5. Density: g/cm3
    6. Vapor Pressure: 0.0182mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE(2192-06-5)
    12. EPA Substance Registry System: 2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE(2192-06-5)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 43
    3. Safety Statements: 36/37
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2192-06-5(Hazardous Substances Data)

2192-06-5 Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE is used as an antitubercular agent for the treatment of tuberculosis, particularly in cases of drug-resistant strains, due to its potential to inhibit the growth of mycobacteria.
Used in Combination Therapy:
In the field of Tuberculosis Treatment, 2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE is used as a component in combination therapy to enhance the effectiveness of treatment against tuberculosis, given its ability to target resistant strains of the disease.
Used in Research and Development:
2-AMINO-4,5-DIHYDRO-1,3-THIAZOL-4-ONE HYDROCHLORIDE is utilized as a subject of research for further exploration of its antimicrobial properties and to understand its mechanism of action, which can contribute to the development of new treatments for various bacterial infections.

Check Digit Verification of cas no

The CAS Registry Mumber 2192-06-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,9 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2192-06:
(6*2)+(5*1)+(4*9)+(3*2)+(2*0)+(1*6)=65
65 % 10 = 5
So 2192-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C3H4N2OS.ClH/c4-3-5-2(6)1-7-3;/h1H2,(H2,4,5,6);1H

2192-06-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Aminothiazolinone hydrochloride

1.2 Other means of identification

Product number -
Other names 2-Aminothiazol-4(5H)-one hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2192-06-5 SDS

2192-06-5Relevant articles and documents

Synthesis and alkylation of hexahydro-1,3,5-triazine-2-thione derivatives

Lazarev,Ramsh,Ivanenko

, p. 442 - 449 (2007/10/03)

A series of new hexahydro-1,3,5-triazine-2-thione derivatives were prepared by aminomethylation of thiourea with formaldehyde and primary amines; with aniline as amine component, an abnormal aminomethylation product is formed, 5-phenyl-1-phenylaminomethylhexahydro-1,3,5-triazine-2-thione. Alkylation of 5-tert-butylhexahydro-1,3,5-triazine-2-thione with alkyl halides and with methyl and ethyl bromoacetate yields hydrohalides of 2-alkylthio- and 2-alkoxycarbonylmethylthio-5-tert-butyl-3,4,5,6-tetrahydro-1,3,5-triazines, respectively.

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