Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP
We described the synthesis and biological evaluation of MPEP analogs functionalized at the position 3 of the phenyl ring. The results point out the limitation in the choice of a functional group at this position; the only substituents leading to retention
Alagille, David,Baldwin, Ronald M.,Roth, Bryan L.,Wroblewski, Jarda T.,Grajkowska, Ewa,Tamagnan, Gilles D.