- Compound useful in the treatment or prevention of cognitive disorders associated with diabetes and associated methods
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Described is the efficient synthesis of an easy to manipulate and utilize, soluble tartrate salt of a potent, reversible butyrylcholinesterase inhibitor, (?)-(3aS)-3a-methyl-1,2,3,3a,8,8a-hexahydropyrrolo-[2,3-b]indol-5-yl N—4′-isopropylphenylcarbamate (“
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Page/Page column 4; 5
(2008/06/13)
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- A practical conversion of natural physostigmine into the potent butyrylcholinesterase inhibitor N1,N8-bisnorcymserine
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A rapid novel synthetic route to the potent reversible butyrylcholinesterase inhibitor (-)-N1,N8-bisnorcymserine (1) is reported from physostigmine (2) in a 20% total yield. Details on the formation of the imino-quinone 6 obtained in the oxidation of N1-benzylnoresermethole (4) and its conversion into N1-bisnoreseroline (7) are given. As expected, the product of this synthesis, (1), had identical biological activity to the same agent produced by total synthesis. (C) 2000 Elsevier Science Ltd.
- Zhu, Xiaoxiang,Greig, Nigel H.,Holloway, Harold W.,Whittaker, Noel F.,Brossi, Arnold,Yu, Qian-Sheng
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p. 4861 - 4864
(2007/10/03)
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