220114-32-9

Basic information

• Product Name: Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)
• Synonyms: Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II);RuCl2[(R)-DM-BINAP][(R)-DAIPEN];Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) RuCl2[(R)-xylbinap][(R)-daipen];RuCl2[(R)-xylbinap][(R)-daipen];Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1,1-bis(4-methoxyphenyl);RuCl2[(R)-xylbinap][(R)-daipen] RuCl2[(R)-xylbinap][(R)-daipen]
• CAS NO: 220114-32-9
• Molecular Formula: C₇₁H₇₄Cl₂N₂O₂P₂Ru
• Molecular Weight: 0
• Mol File: 220114-32-9.mol

Chemical Properties

• Melting Point: 197-211 °C
• Appearance: yellow to dark brown or green/solid
• Storage Temp.: 2-8°C
• Sensitive: air sensitive
• CAS DataBase Reference: Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)(CAS DataBase Reference)
• NIST Chemistry Reference: Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)(220114-32-9)
• EPA Substance Registry System: Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)(220114-32-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 220114-32-9(Hazardous Substances Data)

Usage

Uses

Used in Asymmetric Hydrogenation:
Dichloro(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) is used as a catalyst for the asymmetric hydrogenation of amino ketones. The application reason is its ability to selectively catalyze the hydrogenation process, leading to the formation of chiral products with high enantioselectivity and yield.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Dichloro(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) is used as a catalyst for the synthesis of chiral pharmaceutical compounds. The application reason is its ability to facilitate the production of enantiomerically pure drugs, which is crucial for ensuring the desired biological activity and minimizing potential side effects.
Used in Chemical Synthesis:
Dichloro(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II) is used as a catalyst in the synthesis of various chiral compounds, such as chiral alcohols, amines, and other organic molecules. The application reason is its high catalytic efficiency and selectivity, which allows for the production of chiral products with excellent enantiomeric excess and diastereoselectivity.

Reaction

Highly active catalyst for hydrogenation of simple ketones giving high enantioselectivity when sterically unsymmetrical ketones such as acetophenone, heteroaryl ketones, benzophenones, cyclopropyl ketones, and cyclohexyl ketones are substrates. Ee's are enhanced with XylBINAP relative to BINAP. The otherwise poorly bonded ketone is held in the transition state by hydrogen bonding to the protic bidentate amine. Carbonyl groups are selectively reduced even when olefins exist in the same molecule. In the presence of strong base, and catalyst, simple ketones, having substituents at the α-position, may be induced to undergo dynamic kinectic resolution during their hydrogenation to produce two chiral carbon centers in high yield.

Upstream product

• 166764-19-8 R-DAIPEN 
• 1345887-44-6 [RuCl(p-cymene)((R)-xylbinap)]Cl 

Relevant articles and documents

RUTHENIUM COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE ALCOHOL COMPOUND

The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having ruthenacycle structure, a catalyst for asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol using the ruthenium complex.