220239-67-8

Basic information

• Product Name: 2-(Trifluoromethoxy)phenylacetic acid
• Synonyms: 2-(Trifluoromethoxy)phenylacetic acid 98%;2-(Trifluoromethoxy)phenylaceticacid98%;2-(Carboxymethyl)-alpha,alpha,alpha-trifluoroanisole;2-(TRIFLUOROMETHOXY)PHENYLACETIC ACID;RARECHEM AL BO 0857
• CAS NO: 220239-67-8
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.15
• EINECS: -0
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;Phenylacetic acid;Fluorine series
• Mol File: 220239-67-8.mol

Chemical Properties

• Melting Point: 54-56°C
• Boiling Point: 247.9°C at 760 mmHg
• Flash Point: 103.7°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 0.0133mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.02±0.10(Predicted)
• CAS DataBase Reference: 2-(Trifluoromethoxy)phenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Trifluoromethoxy)phenylacetic acid(220239-67-8)
• EPA Substance Registry System: 2-(Trifluoromethoxy)phenylacetic acid(220239-67-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 220239-67-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(Trifluoromethoxy)phenylacetic acid is utilized as a building block in the synthesis of various pharmaceutical compounds for its anti-inflammatory and analgesic properties. It plays a crucial role in the development of non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents, contributing to the treatment of various conditions that require pain relief and inflammation reduction.
Used in Agricultural Applications:
In the agricultural sector, 2-(Trifluoromethoxy)phenylacetic acid has been studied for its potential use as a herbicide. Its application aims to control and manage unwanted plant growth, thereby enhancing crop productivity and quality. 2-(Trifluoromethoxy)phenylacetic acid's effectiveness in this context is under investigation to ensure its safety and efficacy as an agricultural chemical.

InChI:InChI=1/C9H7F3O3/c10-9(11,12)15-7-4-2-1-3-6(7)5-8(13)14/h1-4H,5H2,(H,13,14)

Upstream product

• 137218-25-8 2-(2-trifluoromethoxyphenyl)acetonitrile 

Downstream Products

• 1159678-02-0 C₁₁H₁₁F₃O₃ 
• 1159677-92-5 6-(2-trifluoromethoxy-benzyl)-1-(4-trifluoromethyl-pyridin-3-yl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 1262107-19-6 5-chloro-2-[2-(trifluoromethoxy)phenyl]pentanoic acid 
• 1262106-53-5 8-[4-fluoro-3-(trifluoromethoxy)phenyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine 
• 1262107-18-5 2-{4-chloro-1-[2-(trifluoromethoxy)phenyl]butyl}-5-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-1,3,4-oxadiazole 
• 1262106-52-4 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine 
• 1363397-20-9 tert-butyl 4-((2-(2-(trifluoromethoxy)phenyl)acetoyloxy)methyl)thiazol-2-ylcarbamate 
• 1030630-29-5 N-ethyl-N-(2-pyrrolidin-1-ylethyl)-2-[(2-trifluoromethoxy)phenyl]acetamide 
• 1030630-31-9 N-ethyl-N-(2-piperidin-1-ylethyl)-2-[(2-trifluoromethoxy)phenyl]acetamide 
• 1030630-30-8 N-methyl-N-(2-piperidin-1-ylethyl)-2-[(2-trifluoromethoxy)phenyl]acetamide 
• 1030630-28-4 N-methyl-N-(2-pyrrolidin-1-ylethyl)-2-[(2-trifluoromethoxy)phenyl]acetamide 
• 509143-10-6 N-[4-(4-dimethylamino-quinazolin-2-ylamino)-cyclohexylmethyl]-2-(2-trifluoromethoxy-phenyl)-acetamide 
• 929612-78-2 2-trifluoromethoxyphenylacetyl chloride 

Relevant articles and documents

Tocolytic oxytocin receptor antagonists

This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

PIPERAZINE OXYTOCIN RECEPTOR ANTAGONISTS

This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.