- Preparation method of oteracil potassium
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The invention provides a preparation method of oteracil potassium. The method comprises the following steps: dissolving allantoin, an alkali and potassium iodide in purified water at room temperature;and cooling an obtained reaction solution, adding N-halogenated amide in batches, carrying out heating reaction after the addition is completed, cooling the reaction solution after the reaction is detected to be completed, adjusting the pH value with an acid, carrying out suction filtration after stirring and crystal growing, washing a filter cake with cold purified water until the filter cake iscolorless, leaching with a cold anhydrous alcohol solvent, and carrying out vacuum drying to obtain potassium oteracil. Compared with the prior art, the method has the advantages of simple and easilyavailable raw materials, simple operation, mild reaction conditions, stable quality, high yield, no pollution to the environment, and suitableness for industrial production.
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Paragraph 0040-0065
(2020/01/25)
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- Synthesis method of oteracil potassium
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The invention provides a synthetic method of oteracil potassium. The method comprises the following steps: adding 2-carbamoyl amino-2-oxyacetic acid, urea and a catalyst into a solvent at room temperature, carrying out heating cyclization reaction, detecting until the reaction is finished, cooling, adjusting the pH value of a reaction solution, forming a potassium salt, stirring, growing crystals,carrying out suction filtration, washing a filter cake with purified water and cold anhydrous alcohol in sequence, and carrying out vacuum drying to obtain oteracil potassium. Compared with the priorart, the method has the advantages of simple and easily available raw materials, simple operation, mild reaction conditions, stable quality, high yield, no pollution to the environment, and suitableness for industrial production.
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Paragraph 0039-0064
(2020/01/25)
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- Method for preparing potassium oxonate
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The invention belongs to the technical field of chemical synthesis and particularly relates to a method for preparing potassium oxonate, comprising the following steps: dissolving potassium hydroxide in water, clarifying and then cooling to 0-5 DEG C, adding potassium iodide, adding allantoin in batch, stirring for dissolving, dropwise adding bromine at a controlled temperature of 0-5 DEG C for 7-11 h, stirring at 0-5 DEG C for 1 after dropwise adding, heating to 20-25 DEG C and reacting for 18-22 h, and detecting allantoin being 0.6% through HPLC (high performance liquid chromatography), cooling to 0-5 DEG C, dropwise adding acetic acid to adjust pH to 5, filtering, washing with water, washing with ethanol, and drying to obtain the potassium oxonate. The method has good reaction effect, high product yield and low cost, is simple to perform and is particularly applicable to industrial application.
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Paragraph 0019; 0020; 0021
(2017/05/23)
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- Method for producing potassium oxonate
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A method for producing potassium oxonate which comprises dissolving allantoin in an aqueous potassium hydroxide solution or an aqueous potassium carbonate solution, and oxidizing said allantoin with an alkali metal hypohalogenite in the presence of potassium iodide is provided and, according to the method, potassium oxonate can be efficiently produced without requiring a manganese compound which may entail environmental pollution.
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- THE MECHANISM FOR THE CONVERSION OF URIC ACID INTO ALLANTOIN AND DEHYDRO-ALLANTOIN. A NEW LOOK AT AN OLD PROBLEM
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The reaction of uric acids 1 with iodine in alkaline solution yields, on acidification, new dehydroallantoins 11, or normal oxidation products, allantoins 13, depending on whether an excess or a stoichiometric amount of oxidant was used.The structure and regiochemistry of dehydro-allantoins 11 was established by chemical, spectroscopic, and 14C-labelling methods.These experimental results, in combination with other data, generate a new mechanistic scheme for the uricolytic pathway to allantoin, ruling out the intervention of a symmetrical transition state prior to the decarboxylation step.
- Poje, M.,Sokolic-Maravic, Lea
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p. 747 - 752
(2007/10/02)
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