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2207-75-2

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2207-75-2 Usage

Description

Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 2207-75-2 differently. You can refer to the following data:
1. Antitumor effect potentiator and antitumor agent
2. Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats.It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.
3. Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

Check Digit Verification of cas no

The CAS Registry Mumber 2207-75-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,0 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2207-75:
(6*2)+(5*2)+(4*0)+(3*7)+(2*7)+(1*5)=62
62 % 10 = 2
So 2207-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1

2207-75-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (O0164)  Potassium Oxonate  >98.0%(HPLC)(T)

  • 2207-75-2

  • 5g

  • 238.00CNY

  • Detail
  • TCI America

  • (O0164)  Potassium Oxonate  >98.0%(HPLC)(T)

  • 2207-75-2

  • 25g

  • 866.00CNY

  • Detail
  • Aldrich

  • (156124)  Oxonicacidpotassiumsalt  97%

  • 2207-75-2

  • 156124-5G

  • 562.77CNY

  • Detail
  • Aldrich

  • (156124)  Oxonicacidpotassiumsalt  97%

  • 2207-75-2

  • 156124-25G

  • 1,931.67CNY

  • Detail
  • Aldrich

  • (156124)  Oxonicacidpotassiumsalt  97%

  • 2207-75-2

  • 156124-100G

  • 5,725.98CNY

  • Detail

2207-75-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate

1.2 Other means of identification

Product number -
Other names Oxonic acid,potassium salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2207-75-2 SDS

2207-75-2Synthetic route

oxaluric acid
585-05-7

oxaluric acid

urea
57-13-6

urea

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate
2207-75-2

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate

Conditions
ConditionsYield
Stage #1: oxaluric acid; urea With toluene-4-sulfonic acid In ethanol at 50℃; for 6h;
Stage #2: With potassium hydroxide In ethanol; water at 0℃; for 2h; pH=5.5; Temperature; Reagent/catalyst; Solvent; pH-value;
94.64%
Allantoin
97-59-6

Allantoin

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate
2207-75-2

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate

Conditions
ConditionsYield
With N-Bromosuccinimide; potassium iodide; potassium hydroxide In water at 0 - 25℃; for 3h; Temperature; Reagent/catalyst; Darkness;91.32%
dehydro-allantoin
105245-87-2

dehydro-allantoin

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate
2207-75-2

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate

Conditions
ConditionsYield
With potassium hydroxide In water for 0.333333h;82%
acetic acid
64-19-7

acetic acid

Allantoin
97-59-6

Allantoin

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate
2207-75-2

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate

Conditions
ConditionsYield
Stage #1: Allantoin With bromine; potassium iodide; potassium hydroxide In water at 0 - 25℃; for 30h;
Stage #2: acetic acid In water at 0 - 5℃; pH=5; Time;
76.1%
water
7732-18-5

water

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate
2207-75-2

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate

cobalt(II) perchlorate hexahydrate

cobalt(II) perchlorate hexahydrate

[(cobalt(II))3(oxonate)3(H2O)6]2*13H2O

[(cobalt(II))3(oxonate)3(H2O)6]2*13H2O

Conditions
ConditionsYield
In methanol80%
iron(II) perchlorate monohydrate

iron(II) perchlorate monohydrate

water
7732-18-5

water

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate
2207-75-2

monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate

[(iron(II))3(oxonate)3(H2O)6]2*13H2O

[(iron(II))3(oxonate)3(H2O)6]2*13H2O

Conditions
ConditionsYield
In methanol78%

2207-75-2Downstream Products

2207-75-2Relevant articles and documents

Preparation method of oteracil potassium

-

Paragraph 0040-0065, (2020/01/25)

The invention provides a preparation method of oteracil potassium. The method comprises the following steps: dissolving allantoin, an alkali and potassium iodide in purified water at room temperature;and cooling an obtained reaction solution, adding N-halogenated amide in batches, carrying out heating reaction after the addition is completed, cooling the reaction solution after the reaction is detected to be completed, adjusting the pH value with an acid, carrying out suction filtration after stirring and crystal growing, washing a filter cake with cold purified water until the filter cake iscolorless, leaching with a cold anhydrous alcohol solvent, and carrying out vacuum drying to obtain potassium oteracil. Compared with the prior art, the method has the advantages of simple and easilyavailable raw materials, simple operation, mild reaction conditions, stable quality, high yield, no pollution to the environment, and suitableness for industrial production.

Method for preparing potassium oxonate

-

Paragraph 0019; 0020; 0021, (2017/05/23)

The invention belongs to the technical field of chemical synthesis and particularly relates to a method for preparing potassium oxonate, comprising the following steps: dissolving potassium hydroxide in water, clarifying and then cooling to 0-5 DEG C, adding potassium iodide, adding allantoin in batch, stirring for dissolving, dropwise adding bromine at a controlled temperature of 0-5 DEG C for 7-11 h, stirring at 0-5 DEG C for 1 after dropwise adding, heating to 20-25 DEG C and reacting for 18-22 h, and detecting allantoin being 0.6% through HPLC (high performance liquid chromatography), cooling to 0-5 DEG C, dropwise adding acetic acid to adjust pH to 5, filtering, washing with water, washing with ethanol, and drying to obtain the potassium oxonate. The method has good reaction effect, high product yield and low cost, is simple to perform and is particularly applicable to industrial application.

THE MECHANISM FOR THE CONVERSION OF URIC ACID INTO ALLANTOIN AND DEHYDRO-ALLANTOIN. A NEW LOOK AT AN OLD PROBLEM

Poje, M.,Sokolic-Maravic, Lea

, p. 747 - 752 (2007/10/02)

The reaction of uric acids 1 with iodine in alkaline solution yields, on acidification, new dehydroallantoins 11, or normal oxidation products, allantoins 13, depending on whether an excess or a stoichiometric amount of oxidant was used.The structure and regiochemistry of dehydro-allantoins 11 was established by chemical, spectroscopic, and 14C-labelling methods.These experimental results, in combination with other data, generate a new mechanistic scheme for the uricolytic pathway to allantoin, ruling out the intervention of a symmetrical transition state prior to the decarboxylation step.

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