220772-32-7

Basic information

• Product Name: 4-(3,4-DICHLOROBENZYL)-PIPERIDINE
• Synonyms: 4-(3,4-DICHLOROBENZYL)-PIPERIDINE;OTAVA-BB 1043266;4-(3,4-DICHLOROBENZYL)PIPERIDINE HCL;4-[(3,4-Dichlorophenyl)methyl]piperidine HCl
• CAS NO: 220772-32-7
• Molecular Formula: C₁₂H₁₅Cl₂N
• Molecular Weight: 244.16
• Mol File: 220772-32-7.mol

Chemical Properties

• Boiling Point: 341.1°C at 760 mmHg
• Flash Point: 160.1°C
• Appearance: /
• Density: 1.192g/cm³
• Vapor Pressure: 8.22E-05mmHg at 25°C
• Refractive Index: 1.551
• PKA: 10.49±0.10(Predicted)
• CAS DataBase Reference: 4-(3,4-DICHLOROBENZYL)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-DICHLOROBENZYL)-PIPERIDINE(220772-32-7)
• EPA Substance Registry System: 4-(3,4-DICHLOROBENZYL)-PIPERIDINE(220772-32-7)

Safety Data

• Hazardous Substances Data: 220772-32-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15Cl2N/c13-11-2-1-10(8-12(11)14)7-9-3-5-15-6-4-9/h1-2,8-9,15H,3-7H2

Upstream product

• 220772-31-6 1-(tert-butoxycarbonyl)-4-(3,4-dichlorobenzyl)piperidine 
• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 18282-59-2 4-bromo-1,2-dichlorobenzene 

Downstream Products

• 220772-33-8 1-(S)-[4-(3,4-dichlorobenzyl)piperidin-1-ylcarbonyl]-N-(tert-butoxycarbonyl)-2-methylpropylamine 

Relevant articles and documents

The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists

Bipiperidine amide 1 has been identified as a CC chemokine receptor 3 (CCR3) antagonist. Optimization of its structure-activity relationship has resulted in the identification of cis (R,R)-4-[(3,4-dichlorophenyl)methyl]-3- hydroxymethyl-1′(6-quinolinylcar

Piperidinyl and piperazinyl compounds substituted with bicyclo-heterocyclylalkyl groups useful as CCR3 receptor antagonists

Compounds having the Formula (I), are useful as CCR3 receptor antagonists, wherein Ar is aryl or heteroaryl; Q is —C(═O)— or C1-2alkylene; X is N(+)R9a, or N; Y is CR9b, or N; R2 is hydrogen or alkyl; R3 and R4 are as defined in the specification; Uc is a mono- or bicyclic group as defined in the specification; n is 0 or 1; and p is 0, 1, 2, 3 or 4.

Cyclic amine derivatives-CCR-3 receptor antagonists

This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonist, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Piperidine quaternary salts- CCR- 3 receptor antagonists

This invention relates to certain piperidine quatemrwy salts of Formula (I): that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

Cyclic amine derivatives- CCR-3 receptor antagonists

This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.