18282-59-2

Basic information

• Product Name: 1-Bromo-3,4-dichlorobenzene
• Synonyms: 4-bromo-1,2-dichloro-benzen;Benzene, 1-bromo-3,4-dichloro-;Benzene,4-bromo-1,2-dichloro-;3,4-DICHLOROBROMOBENZENE;4-BROMO-1,2-DICHLOROBENZENE;1-BROMO-3,4-DICHLOROBENZENE;1-Bromo-3,4-dichlorobenzene, 98+%;3,4-Dichloro-1-bromobenzene
• CAS NO: 18282-59-2
• Molecular Formula: C₆H₃BrCl₂
• Molecular Weight: 225.9
• EINECS: 242-160-6
• Product Categories: Aromatic Halides (substituted);Benzene derivates;API intermediates;Bromine Compounds;Chlorine Compounds;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 18282-59-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 24-25 °C(lit.)
• Boiling Point: 124 °C33 mm Hg(lit.)
• Flash Point: 189 °F
• Appearance: Clear slightly yellow/Liquid After Melting
• Density: 1.761 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0706mmHg at 25°C
• Refractive Index: n20/D 1.599(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: insoluble
• BRN: 1635735
• CAS DataBase Reference: 1-Bromo-3,4-dichlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-3,4-dichlorobenzene(18282-59-2)
• EPA Substance Registry System: 1-Bromo-3,4-dichlorobenzene(18282-59-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-28A
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 18282-59-2(Hazardous Substances Data)

Usage

Chemical Properties

colorless to light yellow liqui

General Description

4-Bromo-1,2-dichlorobenzene participates in the synthesis of N-arylated sultams.

InChI:InChI=1/C6H3BrCl2/c7-4-1-2-5(8)6(9)3-4/h1-3H

Upstream product

• 19763-90-7 3,4-dichlorophenylhydrazine hydrochloride 
• 95-50-1 1,2-dichloro-benzene 
• 95-76-1 m,p-dichloroaniline 

Downstream Products

• 1372186-63-4 3-(3,4-dichlorophenyl)-3-hydroxy-4-(4-methoxyphenoxy)butanenitrile 
• 1372186-64-5 4-amino-2-(3,4-dichlorophenyl)-1-(4-methoxyphenoxy)butan-2-ol 
• 1372186-65-6 N-benzyl-2-chloro-N-[3-(3,4-dichlorophenyl)-3-hydroxy-4-(4-methoxyphenoxy)butyl]acetamide 
• 1372186-66-7 4-(benzylamino)-2-(3,4-dichlorophenyl)-1-(4-methoxyphenoxy)butan-2-ol 
• 1372186-67-8 4-benzyl-7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepan-3-one 
• 1372186-68-9 4-benzyl-7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane 
• 1372186-69-0 tert-butyl 7-(3,4-dichlorophenyl)-7-[(4-methoxyphenoxy)methyl]-1,4-oxazepane-4-carboxylate 
• 1372189-34-8 tert-butyl 7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate 
• 1372186-70-3 tert-butyl (7RS)-7-(3,4-dichlorophenyl)-7-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1,4-oxazepane-4-carboxylate 
• 1372186-71-4 tert-butyl (7RS)-7-(aminomethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate 
• 1372186-75-8 1,2-dichloro-4-{1-[(4-methoxyphenoxy)methyl]ethenyl}benzene 
• 1372186-76-9 (2RS)-2-(3,4-dichlorophenyl)-2-[(4-methoxyphenoxy)methyl]oxirane 
• 1372186-77-0 tert-butyl [(2RS)-2-(3,4-dichlorophenyl)-2-hydroxy-3-(4-methoxyphenoxy)propyl](3-hydroxypropyl)carbamate 
• 1155558-39-6 1-(3,4-dichlorophenyl)-2-(4-methoxyphenoxy)ethanone 

Relevant articles and documents

Metal- and base-free synthesis of aryl bromides from arylhydrazines

An efficient method was developed to synthesize brominated aromatic compounds from arylhydrazine hydrochlorides by using BBr3 in DMSO/CPME (cyclopentyl methyl ether) under air at 80 °C for 1 h without the use of bases or metal catalysts. In particular, this method could be carried out satisfactorily using electron-withdrawing groups to afford aryl bromides in a moderate to excellent yields.

One-Pot, Metal-Free Conversion of Anilines to Aryl Bromides and Iodides

A metal-free synthesis of aryl bromides and iodides from anilines via halogen abstraction from bromotrichloromethane and diiodomethane is described. This one-pot reaction affords aryl halides from the corresponding anilines in moderate to excellent yields without isolation of diazonium salts. The transformation has short reaction times, a simple workup, and insensitivity to moisture and air and avoids excess halogenation. DFT calculations support a SRN1 mechanism. This method represents a convenient alternative to the classic Sandmeyer reaction.

Potential noncataleptic neuroleptic agents: 2,3-dichloro-10-[4-(2-hydroxyethyl)piperazino]-10,11-dihydrodibenzo[b,f]thie pin

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