220991-32-2Relevant articles and documents
Preparation method of robencoxib intermediate
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Paragraph 0064-0066, (2021/04/21)
The invention relates to a preparation method of a robencoxib intermediate, and belongs to the technical field of pharmacy. The preparation method disclosed by the invention comprises the following step of: reacting a compound R1-RBC04 in the presence of
Preparation method of robecoxib
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Paragraph 0033; 0040-0043; 0050-0052; 0059-006, (2020/11/02)
The invention relates to a preparation method of robecoxib. The preparation method comprises the following steps: under the protection of inert gas, adding 5-ethylindole-2-ketone, 2, 3, 5, 6-tetrafluoroiodobenzene, a catalyst, alkali, a ligand and a solve
Method for preparing acid
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Paragraph 0006; 0042-0043, (2019/05/11)
The invention relates to a method for preparing an acid, and belongs to the technical field of pharmacy. The method comprises: carrying out a reaction on a reaction material and an alkali in an organic solvent, making the reaction product contact hydrazin
Method for preparing robenacoxib
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, (2019/04/04)
The invention belongs to the technical field of production of non-steroidal anti-inflammatory drugs and relates to a method for preparing robenacoxib. The method specifically comprises the following steps: (1) in the presence of nitrogen, adding a solvent
Removal of heavy metals from organic reaction mixtures: Preparation and application of functionalized resins
Barbaras, Damien,Brozio, Joerg,Johannsen, Ib,Allmendinger, Thomas
scheme or table, p. 1068 - 1079 (2010/04/22)
Using a toolbox, sulfur and amine ligands are attached to a variety of hydrophobic and hydrophilic resins, and the combinations were tested for the removal of heavy metals from a number of products, prepared by metal-catalyzed reactions. As a result, cheap combinations of silica resins and simple polyamines proved to be among the most effective metal scavengers particularly in apolar solvents such as cyclohexane. Expensive cyclic polyamines are not suitable, owing to kinetic retardation of complexation. Functionalized PEGbased polymers, originally designed for solid phase synthesis, show promising performance as metal scavengers. The results are discussed and compared to alternative approaches for purification such as salt-formation and chemical downstream transformation.
Method for the treatment and prevention of cachexia
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, (2008/06/13)
Cachexia, including anorexia and other forms of weight loss, is a frequent complication of acute and chronic infections, and result from induction of cytokines, prostaglandins, and other inflammatory mediators that are critical for pathogen elimination. The present invention includes methods for the treatment or prevention of cachexic conditions while maintaining the production of factors essential for infection control through the administration of an effective amount of a cyclooxygenase-2 selective inhibiting compound.
Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
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, (2008/06/13)
Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1is chloro or fluoro; R2is hydrogen or fluoro; R3is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4is hydrogen or fluoro; and R5is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.