- Complexes of 2-hydroxyacetophenone semicarbazones: A novel series of superoxide dismutase mimetics
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A series of copper(II) and zinc complexes of 2-hydroxyacetophenone semicarbazones have been prepared and evaluated as superoxide dismutase (SOD) mimetics. The SOD-like activity of parent ligands and complexes were determined by the inhibition of nitroblue tetrazolium (NBT) reduction method, using xanthine/xanthine oxidase as the superoxide radical generator. The obtained results indicate that Cu(II) complexes exhibited the most potent SOD-like activities with the IC50 values ranging from ca. 0.2 to 4 μM. Among copper complexes, 2-hydroxy-4-methoxyacetophenone semicarbazone analog was the most active compounds (IC50 ≈0.2 μM).
- Safavi, Maliheh,Foroumadi, Alireza,Nakhjiri, Maryam,Abdollahi, Mohammad,Shafiee, Abbas,Ilkhani, Hoda,Ganjali, Mohammad Reza,Hosseinimehr, Seyed Jalal,Emami, Saeed
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scheme or table
p. 3070 - 3073
(2010/07/18)
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- MULTINUCLEAR MAGNETIC RESONANCE AND RELATED STUDIES ON AZOMETHINE BORON COMPLEXES OF SEMICARBAZONES AND THIOSEMICARBAZONES
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Synthetic and stereochemical features of some interesting boron complexes have been described.These three and four coordinated complexes have been prepared by the interaction of 2-isopropoxy-1, 3,2-benzodioxaborole with semicarbazones and thiosemicarbazones having the donor sets NOH and NSH in unimolar ratio and with semicarbazones and thiosemicarbazones having the donor sets HONOH and OHNSH in 1:1 and 2:1 molar ratios.Depending on the stoichiometry of the reactions, different moles of isopropanol are liberated and a variety of new boron azomethine complexes are obtained.On the basis of IR, (1)H NMR, (11)B NMR and (13)C NMR data plausible geometries have been proposed for the resulting derivatives, X-ray powder diffraction studies of a representative compound have also been carried out and the results show that adopts 'orthorhombic' type of lattice with unit cell dimensions; a= 10.84 Angstroem, b= 24.12 Angstroem, and c= 28.74 Angstroem.
- Bhal, L.,Singh, R. V.,Tandon, J. P.
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p. 251 - 260
(2007/10/02)
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