221665-95-8Relevant articles and documents
Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor
Yuan, Xi,Yao, Jian-Fei,Tang, Zhen-Yu
supporting information, p. 1410 - 1413 (2017/03/23)
A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li2CO3 as base at low temperature.
Electron-rich five-membered heterocyclic acid and method for decarboxylation and fluorination of derivative thereof
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Paragraph 0114; 0115; 0116; 0117; 0118, (2017/06/02)
The invention provides electron-rich five-membered heterocyclic acid and a method for decarboxylation and fluorination of derivatives thereof. High-efficiency decarboxylation and fluorination are performed on the electron-rich five-membered heterocyclic acid with different kinds of electron-rich five-membered heterocycles connected with carboxylic acid directly, and the derivatives of the electron-rich five-membered heterocyclic acid, An obtained product has high yield and the process is simple.
A synthesis of 3-fluoroindoles and 3,3-difluoroindolines by reduction of 3,3-difluoro-2-oxindoles using a borane tetrahydrofuran complex
Torres, Jose C.,Garden, Simon J.,Pinto, Angelo C.,Da Silva, Filipe S. Q.,Boechat, Nubia
, p. 1881 - 1892 (2007/10/03)
A borane tetrahydrofuran complex has been used to study the reduction of 3,3-difluoro-2-oxindoles and been found to yield either 3-fluoroindoles or 3,3-difluoroindolines. The latter have been found to be reasonably stable when the aromatic nucleus is subs
