221695-47-2

Basic information

• Product Name: 10,11-DIDEHYDROQUINCORINE
• Synonyms: 10,11-DIDEHYDROQUINCORINE
• CAS NO: 221695-47-2
• Molecular Formula: C10H15 N O
• Molecular Weight: 165.23
• Mol File: 221695-47-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 10,11-DIDEHYDROQUINCORINE(CAS DataBase Reference)
• NIST Chemistry Reference: 10,11-DIDEHYDROQUINCORINE(221695-47-2)
• EPA Substance Registry System: 10,11-DIDEHYDROQUINCORINE(221695-47-2)

Safety Data

• Hazardous Substances Data: 221695-47-2(Hazardous Substances Data)

Usage

Chemical compound

A substance formed by a chemical reaction, with a specific molecular structure and properties.

Found in

Corydalis yanhusuo, a plant species commonly known as Yanhusuo.

Type of compound

Alkaloid, a class of naturally occurring compounds containing basic nitrogen atoms.

Pharmacological properties

The study of the interactions between drugs and living systems, including their potential therapeutic effects.

Potential treatment

Pain and neurodegenerative diseases, such as chronic pain management and neurodegenerative disorders.

Analgesic effects

The ability to relieve pain, making it a potential candidate for pain management.

Neuroprotective effects

The ability to protect the nervous system from damage or degeneration, which could be useful in treating neurodegenerative diseases.

Mechanisms of action

The specific ways in which a drug or compound interacts with the body to produce its effects, which are not yet fully understood for 10,11-Didehydroquincorine.

Therapeutic applications

The potential use of a drug or compound in the treatment of specific diseases or conditions, which requires further research to determine for 10,11-Didehydroquincorine.

Further research needed

Additional studies are required to fully understand the properties, mechanisms of action, and potential therapeutic applications of 10,11-Didehydroquincorine.

Upstream product

• 207129-35-9 [(2R,4S,5R)-2-hydroxymethyl-5-vinyl-2-quinuclidine] 
• 207129-36-0 [(2S,4S,5R)-2-hydroxymethyl-5-vinyl-2-quinuclidine] 

Downstream Products

• 475160-60-2 (1S,2S,4S,5R)-2-(aminoethyl)-5-ethynyl-1-azabicyclo[2.2.2]octane 

Relevant articles and documents

Synthesis of new quinuclidine derivatives via Pd-mediated cross-coupling and cross-benzannulation reactions

New functionalized quinuclidines were prepared via palladium-catalyzed addition reactions of terminal alkynes (donors) to internal alkynes (acceptors). The enantiopure terminal alkynes were derivatives of quincoridine and quincorine, two semi-natural Cinc

Synthetic and structural studies of PdII and PtII complexes with quincorine and quincoridine derivatives

A series of PdII-quincorine and -quincoridine complexes in which the ligands are coordinated through N,O-donor atoms have been synthesised, and their structural features determined by X-ray crystallography. Additionally, new chiral tetradentate N,P-ligands containing two quinuclidine cores bridged through a cis-enediyne fragment have been obtained. The different coordinating properties of the new ligands, which contain two soft phosphorus and two hard nitrogen donors, to PdII and PtII are emphasised. Several typical complexes were structurally characterised by X-ray crystallography. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).

Cross-coupling reactions in Cinchona alkaloid chemistry: Aryl-substituted and dimeric quinine, quinidine, as well as quincorine and quincoridine derivatives

Cross-coupling reactions of modified Cinchona alkaloids provide access to a wide variety of novel arylated and dimeric derivatives of quinine and quinidine containing a single and double 1,2-amino alcohol functionality. Sonogashira and Heck reactions allow functionalization of ethynyl and 11-iodovinyl precursors. The role of bystander functionality is investigated.

Synthesis of 10,11-didehydro- and 10,11-dihydro-quincorine and of the quincoridine analogs: Functionalized and enantiopure 1-azabicyclo[2.2.2]- octanes with four stereogenic centers

The convenient synthesis of 10,11-didehydro-QCI (2) and of 10,11- didehydro-QCD (4) as well as 10,11-dihydro-QCI (5) and 10,11-dihydro-QCD (6) is described. Conversion of the olefinic double bond of Quincorine 1 and Quincoridine 3 into the corresponding alkynes 2 and 4 involves twofold dehydrobromination, and an important application of the solid KOH/aliquat 336 system in the key step. The structure of didehydro-QCI (2) has been elucidated by X-ray crystal diffraction. The new alkynes 2 and 4 are more polar and more basic than QCI and QCD, respectively.