222313-83-9Relevant articles and documents
Cell death inhibitor and novel compound
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Paragraph 0223-0226, (2018/03/13)
Provided is a cell-death inhibitor including, as an active ingredient thereof, a compound represented by formula (1), and/or a compound represented by formula (2). The cell-death inhibitor exhibits high cell-death inhibition activity.
2-(Trifluoroacetyl)imidazoles, 2-trifluoroacetyl-1,3-thiazoles, and 2-trifluoroacetyl-1,3-oxazoles
Khodakovskiy, Pavel V.,Volochnyuk, Dmitriy M.,Panov, Dmitriy M.,Pervak, Igor I.,Zarudnitskii, Evgenij V.,Shishkin, Oleg V.,Yurchenko, Aleksandr A.,Shivanyuk, Alexander,Tolmachev, Andrey A.
, p. 948 - 956 (2008/09/21)
A facile method of trifluoroacylation of imidazoles, 1,3-thiazoles, and 1,3-oxazoles with trifluoroacetic anhydride resulted in a set of heterocyclic trifluoromethyl-containing ketones. Unlike common ketones, these compounds form stable hydrates and enter into noncatalytic ene reactions with terminal olefins affording the corresponding allyl alcohols. Georg Thieme Verlag Stuttgart.
α-Trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines
Kawase, Masami,Sakagami, Hiroshi,Kusama, Kaoru,Motohashi, Noboru,Saito, Setsuo
, p. 3113 - 3118 (2007/10/03)
Cytotoxic activity of newly synthesized trifluoromethyl ketones and related compounds was studied using two human oral tumor cell lines (HSG and HSC-2). Among them, α-trifluoromethylacyloins (1 and 2) were found to induce apoptotic cell death, as judged by the terminal deoxynucleotidyl transferase (TdT) dUTP nick end-labeling (TUNEL) method which detects DNA nick or fragments. Furthermore, the cytoplasm of 1 or 2 treated HSG cells was stained by M30 monoclonal antibody, which detects the product resulting from the cleavage of cytokeratin 18 by activated caspase.
