- A nucleophilic 1,3-rearrangement leading to 3,4-disubstituted 3,4-dihydroquinolines
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A new nucleophilic 1,3-rearrangement is observed when treating 2-methoxyquinolino-3-lithium with an α-C substituted deoxybenzoin, and this rearrangement yielded an unusual 3,4-disubstituted 3,4-dihydroquinoline. Several similar reactions were designed and executed to investigate this novel 1,3-rearrangement, and a mechanism involving a nucleophilic addition and a following 1,3-rearrangement with an unusual dearomatization on the quinoline ring is proposed.
- He, Chun-Xian,Jiang, Zhi-Bo,Cui, Hua-Qing,Yin, Da-Li
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- New synthetic approaches towards analogues of bedaquiline
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Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control the worldwide spread of tuberculosis (TB). Bedaquiline has recently emerged as a new drug developed to specifically treat MDR-
- Priebbenow, Daniel L.,Barbaro, Lisa,Baell, Jonathan B.
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p. 9622 - 9628
(2016/10/25)
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