222317-29-5Relevant academic research and scientific papers
A nucleophilic 1,3-rearrangement leading to 3,4-disubstituted 3,4-dihydroquinolines
He, Chun-Xian,Jiang, Zhi-Bo,Cui, Hua-Qing,Yin, Da-Li
, p. 1036 - 1039 (2016)
A new nucleophilic 1,3-rearrangement is observed when treating 2-methoxyquinolino-3-lithium with an α-C substituted deoxybenzoin, and this rearrangement yielded an unusual 3,4-disubstituted 3,4-dihydroquinoline. Several similar reactions were designed and executed to investigate this novel 1,3-rearrangement, and a mechanism involving a nucleophilic addition and a following 1,3-rearrangement with an unusual dearomatization on the quinoline ring is proposed.
New synthetic approaches towards analogues of bedaquiline
Priebbenow, Daniel L.,Barbaro, Lisa,Baell, Jonathan B.
, p. 9622 - 9628 (2016/10/25)
Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control the worldwide spread of tuberculosis (TB). Bedaquiline has recently emerged as a new drug developed to specifically treat MDR-
