Atorvastatin, an HMG-CoA reductase inhibitor and effective lipid-regulating agent. Part III. Syntheses of [2H5]-, [13C8], and [13C7,15N]atorvastatin and their application in metabolic and pharmacokinetic studies
Three stable-isotope-labeled forms of atorvastatin, [2H5], [13C8], and [13C7,15N], were synthesized. They were utilized primarily for metabolic mapping and pharmacokinetic studies of bioequivalence. Analytical assays were performed by using LC/MS/MS methodologies.
Woo, Peter W. K.,Hartman, Jon,Hicks, James,Hayes, Roger