- PHOSPHATE DERIVATIVES AND USE THEREOF
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The present invention discloses a compound with the following formula (I), or a tautomer, mesomer, racemate, enantiomer, and diastereoisomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof, or a prodrug molecule thereof, wherein D is selected from: The invention further discloses the use of the compound in the preparation of drugs for preventing and/or treating cancers, and the use of the compound in the preparation of drugs for inhibiting cancer metastasis. The compound of the present invention can effectively inhibit the proliferation and metastasis of cancer cells by adjusting the acidity of a tumor microenvironment to achieve a better effect in clinical cancer treatment, and has broad application prospects.
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Paragraph 0151; 0152
(2021/02/05)
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- AN EFFICIENT PREPARATION OF ALKYL α-BROMOMETHYLACRYLATES BY DEHYDROBROMINATION OF ALKYL β,β'-DIBROMOISOBUTYRATES WITH POTASSIUM FLUORIDE
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1 and 2 alkyl esters of β,β'-dibromoisobutyric acid are efficiently dehydrobrominated to alkyl α-bromomethylacrylates by anhydrous potassium fluoride (2.5 equiv) in refluxing acetonitrile/DMF (85:15). 3 isobutyrates give reduced yields of acrylates due to accompanying cleavage of the ester by the HF produced.
- Anzeveno, Peter B.,Campbell, Jeffrey A.,White, William L.
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p. 387 - 392
(2007/10/02)
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- Preparation of t-Butyl 2-(Phenylthiomethyl)propenoate, t-Butyl 3-(Phenylthio)-2-(phenylthiomethyl)propenoate and Related Compounds
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The preparation of t-butyl 2-(phenylthiomethyl)propenoate, t-butyl and methyl 3-(phenylthio)-2-(phenylthiomethyl)propenoate, the corresponding carboxylic acids, and 3-(phenylthio)-2-(phenylsulfinylmethyl)propenoate from 3-bromo-2-(bromomethyl)propionic acid is described.
- Haynes, Richard K.,Katsifis, Andrew,Vonwiller, Simone C.
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p. 1571 - 1578
(2007/10/02)
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