223514-48-5

Basic information

• Product Name: 1-(5-Bromo-thiazol-2-yl)-piperazine
• Synonyms: 1-(5-Bromo-thiazol-2-yl)-piperazine;5-BROMO-2-(PIPERAZIN-1-YL)THIAZOLE
• CAS NO: 223514-48-5
• Molecular Formula: C₇H₁₀BrN₃S
• Molecular Weight: 248.14
• Product Categories: pharmacetical
• Mol File: 223514-48-5.mol

Chemical Properties

• Boiling Point: 350.1°Cat760mmHg
• Flash Point: 165.5°C
• Appearance: /
• Density: 1.584g/cm³
• Vapor Pressure: 4.5E-05mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(5-Bromo-thiazol-2-yl)-piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Bromo-thiazol-2-yl)-piperazine(223514-48-5)
• EPA Substance Registry System: 1-(5-Bromo-thiazol-2-yl)-piperazine(223514-48-5)

Safety Data

• Hazardous Substances Data: 223514-48-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(5-Bromo-thiazol-2-yl)-piperazine serves as a key building block in the synthesis of various biologically active compounds, including potential drug candidates. Its unique structure allows for the development of new therapeutic agents with diverse applications.
Used in Medicinal Chemistry Research:
As a valuable tool in medicinal chemistry, 1-(5-Bromo-thiazol-2-yl)-piperazine is utilized for the exploration of its potential anti-cancer, anti-inflammatory, and antimicrobial properties. Its reactivity and structural features contribute to the advancement of drug discovery and the understanding of its mechanisms of action.
Used in Drug Development:
1-(5-Bromo-thiazol-2-yl)-piperazine is employed in drug development to create novel therapeutic agents with potential applications in treating various diseases and conditions. Its unique chemical properties facilitate the design and synthesis of new pharmaceutical compounds with improved efficacy and safety profiles.
It is crucial to handle 1-(5-Bromo-thiazol-2-yl)-piperazine with care due to its potential hazards and toxicity, ensuring safe practices in research and development settings.

InChI:InChI=1/C7H10BrN3S/c8-6-5-10-7(12-6)11-3-1-9-2-4-11/h5,9H,1-4H2

Upstream product

• 223514-46-3 4-acetyl-1-(5-bromothiazol-2-yl)piperazine 
• 110-85-0 piperazine 
• 4175-78-4 2,5-dibromo-1,3-thiazole 

Downstream Products

• 223512-30-9 N-(4-((4-(5-Bromothiazol-2-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide 

Relevant articles and documents

BICYCLIC NITROIMIDAZOLES COVALENTLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES

The current invention provides a series of bicyclic nitroimidazole- substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild- type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.

Substituted 1-propiolylpiperazine compounds, their preparation and use

Substituted 1-propiolylpiperazine compounds corresponding to formula I in which X denotes N or C—R2, and n is an integer from 0 to 8, a method for producing such substituted 1-propiolylpiperazine compounds, pharmaceutical compositions containing such substituted 1-propiolylpiperazine compounds, and the use of such substituted 1-propiolylpiperazine compounds for modulating mGluR5 receptor activity or for treating or inhibiting pain and various other conditions, especially conditions at least partly mediated by the mGluR5 receptor.

[4-(HETEROARYL) PIPERAZIN-1-YL]-(2,5-SUBSTITUTED -PHENYL)METHANONE DERIVATIVES AS GLYCINE TRANSPORTER 1 (GLYT-1) INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

The present invention relates to compounds of the general formula (I) wherein R1 is-OR1’,-SR1’ or is a heterocycloalkyl group; R1’ is lower alkyl, lower alkyl substituted by halogen or is -(CH2)n

Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

Piperazine compounds and medicinal use thereof

The present invention relates to a piperazine compound of the formula wherein R1and R2are each hydrogen, halogen, lower alkyl, lower alkoxy, amino, substituted amino, nitro, hydroxy or cyano, R3, R4and R5are each hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, substituted amino or hydroxy, R6and R7are each hydrogen, lower alkyl, lower alkyl substituted by halogen, aralkyl, acyl or lower acyl substituted by halogen, R8and R9are each hydrogen or lower alkyl, Y is lower alkylene and the like, and ring A is phenyl, pyrimidyl, thiazolyl, pyridyl, pyrazyl or imidazolyl, a pharmaceutically acceptable salt thereof and pharmaceutical agents containing these compounds. The compound of the present invention has superior TNF-α production inhibitory effect and/or IL-10 production promoting effect, and, since it is free of or shows only strikingly reduced expression of an effect on the central nervous system, the compound is useful as a highly safe and superior TNF-α production inhibitor an/or IL-10 production promoter and is useful as an agent for the prophylaxis or treatment of various diseases caused by abnormal TNF-α production, diseases curable with IL-10, such as chronic inflammatory diseases, acute inflammatory diseases, inflammatory diseases due to infection, autoimmune diseases, allergic diseases, and TNF-α mediated diseases.