22378-29-6

Basic information

• Product Name: 1-ETHOXY-4-CHLOROPHTHALAZINE
• Synonyms: 1-ETHOXY-4-CHLOROPHTHALAZINE;1-chloro-4-ethoxyPhthalazine
• CAS NO: 22378-29-6
• Molecular Formula: C₁₀H₉ClN₂O
• Molecular Weight: 208.64
• Mol File: 22378-29-6.mol

Chemical Properties

• Boiling Point: 402.8°C at 760 mmHg
• Flash Point: 197.4°C
• Appearance: /
• Density: 1.284g/cm³
• Vapor Pressure: 2.48E-06mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 1-ETHOXY-4-CHLOROPHTHALAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHOXY-4-CHLOROPHTHALAZINE(22378-29-6)
• EPA Substance Registry System: 1-ETHOXY-4-CHLOROPHTHALAZINE(22378-29-6)

Safety Data

• Hazardous Substances Data: 22378-29-6(Hazardous Substances Data)

Usage

Chemical Class

Phthalazine derivatives

Physical Appearance

White crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Primary Use

Synthesis of pharmaceuticals and agrochemicals

Potential Medical Applications

Antihypertensive agent, therapeutic agent for bronchial asthma

Other Properties

Antimicrobial, antitumor

Importance in Synthesis

Versatile building block for the development of biologically active compounds

InChI:InChI=1/C10H9ClN2O/c1-2-14-10-8-6-4-3-5-7(8)9(11)12-13-10/h3-6H,2H2,1H3

Upstream product

• 4752-10-7 1,4-dichlorophthalazine 
• 141-52-6 sodium ethanolate 
• 64-17-5 ethanol 

Downstream Products

• 484-23-1 1,4-bis(hydrazino)phthalazine 

Relevant articles and documents

Hepatitis C virus inhibitors

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Hepatitis C Virus Inhibitors

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NOVEL ALLYLTHIOPYRIDAZINE DERIVATIVES AND PROCESS FOR PREPARING THE SAME

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Electrochemical reduction of 1,4-disubstituted phthalazines

Electrochemical reduction in dimethylformamide of unsymmetrical 1-Cl-4-X-phthalazines and symmetrical 1,4-X2-phthalazines (X = Cl, PhO, MeO, EtO, i-PrO) was studied by voltammetry and electrolysis-ESR. The electron trasfer on 1,4-dichlorophthalazine and unsymmetrical 1-Cl-4-X-phthalazines induces anionoid elimination of Cl and X, pyridazine ring cleavage, and phthalonitrile formation. In this previously unknown process the transfer of two electrons induces cleavage of three σ bonds and formation of two new π bonds. The reduction of 1,4-dialkoxy(diaryloxy)phthalazines involves formation of stable radical anions which undergo no heteroring cleavage. Possible mechanisms of the processes studied were discussed. It was assumed that the same mechanism with pyridazine ring cleavage may be realized with other phthalazine derivatives and heteroannelated pyridazines containing readily leaving nucleofuge groups α to nitrogens.

Allylthiopyridazine derivatives and process for preparing the same

The, present invention relates to a novel allylthiopyridazine derivative represented by formula (I) which exhibits a superior effect for prevention and treatment or hepatic diseases induced by toxic substances and for protection of human tissues from radi