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CAS

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223915-75-1

8-nitro-2,3,4,5-tetrahydro-1H-benzo[c]azepine, commonly known as nitazepine, is a psychoactive benzazepine compound with sedative and anxiolytic properties. It is a nitrobenzodiazepine derivative that functions by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, resulting in its calming and relaxing effects. Nitazepine is a controlled substance and has been utilized in the treatment of anxiety and insomnia, although its use may be associated with potential side effects and risks, such as dependence and withdrawal symptoms.

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  • 223915-75-1 Structure

  • Basic information

    1. Product Name: 8-nitro-2,3,4,5-tetrahydro-1H-benzo[c]azepine
    2. Synonyms: 8-nitro-2,3,4,5-tetrahydro-1H-benzo[c]azepine
    3. CAS NO:223915-75-1
    4. Molecular Formula: C10H12N2O2
    5. Molecular Weight: 192.21448
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 223915-75-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. CAS DataBase Reference: 8-nitro-2,3,4,5-tetrahydro-1H-benzo[c]azepine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 8-nitro-2,3,4,5-tetrahydro-1H-benzo[c]azepine(223915-75-1)
    11. EPA Substance Registry System: 8-nitro-2,3,4,5-tetrahydro-1H-benzo[c]azepine(223915-75-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 223915-75-1(Hazardous Substances Data)

223915-75-1 Usage

Uses

Used in Pharmaceutical Industry:
8-nitro-2,3,4,5-tetrahydro-1H-benzo[c]azepine is used as a psychoactive drug for the treatment of anxiety and insomnia. It is employed for its sedative and anxiolytic properties, which are attributed to its ability to enhance the effects of the neurotransmitter GABA in the brain, leading to its calming and relaxing effects.
Used in Controlled Substances:
Nitazepine is classified as a controlled substance due to its potential for abuse and the associated risks of dependence and withdrawal symptoms. Its use is regulated in some countries to prevent misuse and ensure that it is prescribed and administered safely and appropriately for medical purposes.

Check Digit Verification of cas no

The CAS Registry Mumber 223915-75-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,9,1 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 223915-75:
(8*2)+(7*2)+(6*3)+(5*9)+(4*1)+(3*5)+(2*7)+(1*5)=131
131 % 10 = 1
So 223915-75-1 is a valid CAS Registry Number.

223915-75-1Relevant articles and documents

NEW COMPOUNDS, PROCESS FOR THEIR PREPARATION, INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OF 5-HT6 MEDIATED DISORDERS SUCH AS ALZHEIMER'S DISEASE, COGNITIVE DISORDERS, COGNITIVE IMPAIRMENT ASSOCIATED WITH SCHIZOPHRENIA, OBESI

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Page/Page column 50, (2008/06/13)

The present invention relates to new compounds of formula (I), or salts, solvates or solvated salts thereof, process for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and

Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and α2-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines

Grunewald, Gary L.,Dahanukar, Vilas H.,Criscione, Kevin R.

, p. 1957 - 1965 (2007/10/03)

2,3,4,5-Tetrahydro-1H-2-benzazepine (THBA; 1) is nearly 100-fold more selective an inhibitor of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) versus the α2-adrenoceptor than is 1,2,3,4-tetrahydroisoquinoline (THIQ; 2) (1: PNMT Ksu

NITROGENOUS FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME

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, (2008/06/13)

A nitrogen-containing condensed heterocyclic derivative of the present invention, which is a compound represented by the formula: wherein ring A represents benzene ring optionally having a further substituent, -L-represents -O-, -NR3a-, -S-, -SO-, -SO2-, -SO2NR3a-, -SO2NHCONR3a-, -SO2NHC(=NH)NR3a-, -C(=S)-, or -CONR3a- (wherein R3a and R3b represent independently hydrogen atom, cyano group, hydroxy group, amino group, a C1-6 alkyl group or a C1-6 alkoxy group), n represents an integer of 0 to 6, R is hydrogen atom or a hydrocarbon group optionally having a substituent, and may be different in repetition of n, R1 represents a hydrocarbon group optionally having a substituent or a group represented by the formula: (wherein R7 represents a hydrocarbon group optionally having a substituent), R2 represents hydrogen atom, an acyl group, a hydrocarbon group optionally having a substituent or a heterocyclic group optionally having a substituent, X represents a bond, O, S, SO, SO2 or NR4 (wherein R4 represents hydrogen atom, an acyl group or a hydrocarbon group optionally having a substituent), k and m represent independently an integer of 0 to 5, and 1k+m5, or a salt thereof, and the like, has an excellent thermal production promoting activity and the like, and is useful as an agent for preventing or treating obesity and obesity-based diseases.

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