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3(S)-Iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C11H20INO2. It is a pyrrolidine derivative that serves as a versatile building block in organic synthesis. The tert-butyl ester group enhances the compound's reactivity and protects the carboxylic acid functionality, enabling its incorporation into a variety of target molecules. The iodomethyl group further enriches its utility as a precursor for synthesizing diverse organic compounds. This chemical is extensively utilized in pharmaceutical and medicinal chemistry research, making it a valuable tool in the development of innovative drugs and biologically active molecules.

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  • 224168-68-7 Structure
  • Basic information

    1. Product Name: 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
    2. Synonyms: 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylic acid, 3-(iodomethyl)-, 1,1-dimethylethyl ester, (3S)-
    3. CAS NO:224168-68-7
    4. Molecular Formula: C10H18INO2
    5. Molecular Weight: 311.16
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 224168-68-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(224168-68-7)
    11. EPA Substance Registry System: 3(S)-IODOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(224168-68-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 224168-68-7(Hazardous Substances Data)

224168-68-7 Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry Research:
3(S)-Iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new drugs and biologically active molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 3(S)-iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is used as a building block for constructing complex organic molecules. The tert-butyl ester group provides a handle for further functionalization, while the iodomethyl group offers opportunities for cross-coupling reactions, leading to the formation of a wide range of organic compounds.
Used in Drug Development:
3(S)-Iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is employed as a crucial component in the development of new drugs. Its versatility in organic synthesis and ability to be incorporated into target molecules make it an indispensable tool in the design and synthesis of novel therapeutic agents.
Used in Chemical Research:
In the realm of chemical research, 3(S)-iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester is utilized as a model compound to study various chemical reactions and mechanisms. Its unique properties and reactivity provide valuable insights into the behavior of similar compounds and contribute to the advancement of chemical knowledge.

Check Digit Verification of cas no

The CAS Registry Mumber 224168-68-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,4,1,6 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 224168-68:
(8*2)+(7*2)+(6*4)+(5*1)+(4*6)+(3*8)+(2*6)+(1*8)=127
127 % 10 = 7
So 224168-68-7 is a valid CAS Registry Number.

224168-68-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl (3S)-3-(iodomethyl)pyrrolidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:224168-68-7 SDS

224168-68-7Downstream Products

224168-68-7Relevant articles and documents

NOVEL PHENYLACETAMIDE COMPOUND AND PHARMACEUTICAL CONTAINING SAME

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Paragraph 0144; 0145, (2015/09/22)

The present invention is to create a compound that selectively activates glucokinase in the liver, and in particular, to provide an agent for treating and preventing diabetes and impaired glucose tolerance, wherein the agent has a low hypoglycemia risk. A

TRICYCLIC COMPOUNDS FOR USE IN THE TREATMENT AND/OR CONTROL OF OBESITY

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Paragraph 00412-00414; 00431-00433, (2014/05/24)

The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against me

METHODS OF TREATING LIVER DISEASES

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Paragraph 00371; 00389, (2014/05/24)

The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.

INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF

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, (2013/02/27)

The present invention relates to a novel indazole- or pyrrolopyridine-derivative, represented by the formula (1) below, that has an agonistic action or a partial agonistic action against serotonin-4 receptor, and a pharmaceutical composition comprising the same. Formula (1) [wherein each substituent is as defined in claim 1]

PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME

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Page/Page column 170; 171, (2012/12/13)

The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

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