- Synthesis of β-chlorohydrins in water
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2,4,6-Trichloro-1,3,5-triazine (TCT, cyanuric chloride) was found to mediate the regio- and stereoselective ring opening of epoxides in H 2O in the presence of morpholine at room temperature to afford the corresponding β-chlorohydrins in excellent yields (Table). The transformation is very simple, fast, efficient, and ecologically beneficial.
- Das, Biswanath,Venkateswarlu, Katta,Krishnaiah, Maddeboina
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- Regio- and stereoselective reaction of α-epoxyketones with AlCl 3: An efficient approach for the synthesis of functionalized β-chlorohydrines
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A simple and efficient synthesis of functionalized β-chlorohydrins is described from the regio- and stereoselective reaction of α-epoxyketones with AlCl3 in acetonitrile at room temperature.
- Nikpour, Farzad,Mozafari, Roya,Mogaddam, Baran Mohammadi
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- DICHLORODIISOPROPOXYTITANIUM - A CONVENIENT REAGENT FOR THE SELECTIVE TRANSFORMATIONS OF α,β-EPOXYCARBONYL COMPOUNDS
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Depending on the structure and the reaction conditions, α,β-epoxycarbonyl compounds isomerize selectively in the presence of dichlorodiisopropoxytitanium to α-diketones or undergo nucleophilic cleavage with the formation of the corresponding hydroxychloro ketones.
- Sosnovskii, G. M.,Astapovich, I. V.
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- An Easy and Efficient Epoxide Opening to give Halohydrins using Tin(II) Halides
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Epoxides are readily converted into halohydrins by tin(II) halides in a variety of solvents.
- Einhorn, Cathy,Luche, Jean-Louis
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p. 1368 - 1369
(2007/10/02)
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- Substituent Effects in 13C-N.M.R. Spectra of Diastereomeric Chalcone Dihalogenides. V. Synthesis, Stereochemistry and Spectroscopy of Chalcone Fluorohydrines
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Chalcone fluorohydrins 1 and diastereomeric pairs of chalcone chlorohydrins 2 as standards are investigated in the i.r., 1H, 19F, and 13C n.m.r. spectroscopy field.The substituent dependence of the spectral parameters is discussed.The assignment of confor
- Weber, Fritz Gerd,Giese, Hartmut,Koeppel, Hubert,Reinhold, Monika,Strobel, Rita,et al.
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p. 133 - 143
(2007/10/02)
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- The Behaviour of Functionally Epoxycarbonyl Compounds with the Reaction of Hydrogen Chloride
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The Conversion of the Mannich base 2 to the hydrochloride proceeds with opening of the oxirane ring yielding 4*2HCl.Contrary to the results with formerly examined epoxides of the chalcone type here in polar as in apolar medium the formation of the erythro
- Moehrle, H.,Schaltenbrand, R.
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p. 387 - 393
(2007/10/02)
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