2252-50-8

Basic information

• Product Name: 2-Chloro-5-fluorobenzoic acid
• Synonyms: 2-Choloro-5-fluorobenzoic acid;BUTTPARK 19\01-68;2-CHLORO-5-FLUOROBENZOIC ACID;5-FLUORO-2-CHLOROBENZOIC ACID;RARECHEM AL BO 2229;2-chloro-5-fluorobenzoicacid,98%;2-Chloro-5-FluorobenzoicAcid99%;2-Chloro-5-Fluorobenzoic Acid 99%
• CAS NO: 2252-50-8
• Molecular Formula: C₇H₄ClFO₂
• Molecular Weight: 174.56
• EINECS: 216-430-9
• Product Categories: Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Miscellaneous;Acids & Esters;Chlorine Compounds;Fluorine Compounds;Benzoic acid Series;Benzenes;Fluorine series;FINE Chemical & INTERMEDIATES;blocks
• Mol File: 2252-50-8.mol

Chemical Properties

• Melting Point: 147-149°C
• Boiling Point: 275.3 °C at 760 mmHg
• Flash Point: 120.3 °C
• Appearance: /
• Density: 1.477 g/cm³
• Vapor Pressure: 0.00249mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 2.54±0.25(Predicted)
• CAS DataBase Reference: 2-Chloro-5-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-fluorobenzoic acid(2252-50-8)
• EPA Substance Registry System: 2-Chloro-5-fluorobenzoic acid(2252-50-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 22-24/25-37-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 2252-50-8(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow powder

InChI:InChI=1/C7H4ClFO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 177480-81-8 4-bromo-2-chloro-5-fluorobenzoic acid 
• 118-91-2 ortho-chlorobenzoic acid 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 89-54-3 2-chloro-5-aminobenzoic acid 

Downstream Products

• 21900-51-6 2-chloro-5-fluorobenzoyl chloride 
• 1312954-65-6 (R)-3-(3-aminopiperidin-1-yl)-4-(2-chloro-5-fluorobenzyl)-6-methyl-1,2,4-triazin-5(4H)-one 
• 1312954-62-3 4-(2-chloro-5-fluorobenzyl)-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one 
• 1312954-63-4 4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one 
• 1312954-64-5 (R)-tert-butyl 1-(4-(2-chloro-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-ylcarbamate 
• 1312954-61-2 methyl 2-(2-(2-chloro-5-fluorobenzylcarbamothioyl)hydrazono)propanoate 
• 647020-63-1 methyl 2-chloro-5-fluorobenzoate 
• 1358761-80-4 2-chloro-5-fluorobenzoic acid N'-t-butylhydrazide 
• 1358761-75-7 2-chloro-5-fluorobenzoic acid N'-2-fluorophenylhydrazide 
• 888952-52-1 5-fluoro-1-(2-fluorophenyl)-2,3-dihydro-1H-indazol-3-one 
• 1358761-79-1 2-chloro-5-fluorobenzoic acid N'-4-methylphenylhydrazide 
• 1358761-68-8 5-fluoro-1-(4-methylphenyl)-2,3-dihydro-1H-indazol-3-one 
• 1256846-68-0 2-chloro-N-benzyl-5-fluorobenzamide 
• 1383572-72-2 N-benzyl-5-fluoro-2-hydroxybenzamide 

Relevant articles and documents

Reactivity control of a photocatalytic system by changing the light intensity

We report a novel light-intensity dependent reactivity approach allowing us to selectively switch between triplet energy transfer and electron transfer reactions, or to regulate the redox potential available for challenging reductions. Simply by adjusting the light power density with an inexpensive lens while keeping all other parameters constant, we achieved control over one- and two-photon mechanisms, and successfully exploited our approach for lab-scale photoreactions using three substrate classes with excellent selectivities and good product yields. Specifically, our proof-of-concept study demonstrates that the irradiation intensity can be used to control (i) the available photoredox reactivity for reductive dehalogenations to selectively target either bromo- or chloro-substituted arenes, (ii) the photochemical cis-trans isomerization of olefins versus their photoreduction, and (iii) the competition between hydrogen atom abstraction and radical dimerization processes.

Regioselective ortho-lithiation of chloro and bromo substituted fluoroarenes

Deprotonation of fluoroarenes carrying chlorine or bromine as additional substituents occurs always at a fluorine adjacent position if accomplished with potassium tert-butoxide activated butyllithium or lithium 2,2,6,6-tetramethylpiperidide.

Fluorine as an ortho-directing group in aromatic metalation: Generality of the reaction and the high position of fluorine in the Dir-Met potency scale

Many para-substituted fluorobenzenes can be lithiated ortho to fluorine in moderate to good yields, often with one of the dialkylamide bases, lithium diisopropylamide (LDA) or lithium 2,2,6,6-tetramethylpiperidide (LiTMP). Intramolecular competition experiments reveal that fluorine is one of the most potent Dir-Met activating groups under these conditions.