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CAS

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225382-63-8

2-(1-methyl-1H-imidazol-5-yl)-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 225382-63-8 Structure

  • Basic information

    1. Product Name: 2-(1-methyl-1H-imidazol-5-yl)-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine
    2. Synonyms: Thieno[3,2-b]pyridin-7-amine, 2-(1-methyl-1H-imidazol-5-yl)-N-(2-methyl-1H-indol-5-yl)-;[2-(3-Methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine
    3. CAS NO:225382-63-8
    4. Molecular Formula: C20H17N5S
    5. Molecular Weight: 359.4475
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 225382-63-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 715.8°C at 760 mmHg
    3. Flash Point: 386.7°C
    4. Appearance: N/A
    5. Density: 1.41g/cm3
    6. Vapor Pressure: 2.44E-20mmHg at 25°C
    7. Refractive Index: 1.769
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(1-methyl-1H-imidazol-5-yl)-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(1-methyl-1H-imidazol-5-yl)-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine(225382-63-8)
    12. EPA Substance Registry System: 2-(1-methyl-1H-imidazol-5-yl)-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine(225382-63-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 225382-63-8(Hazardous Substances Data)

225382-63-8 Usage

Molecular structure

The compound has a thieno[3,2-b]pyridine core with an attached methyl-imidazole group and a methyl-indole group.

Complexity

It is a complex organic compound with multiple functional groups.

Potential applications

The compound has potential applications in medicinal chemistry, particularly in the development of drugs targeting specific biological pathways.

Therapeutic properties

The compound may have potential therapeutic properties, but further research is necessary to fully understand its biological and pharmacological effects.

Importance in pharmaceutical development

The compound has the potential to be an important building block in the development of pharmaceuticals and other biologically active compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 225382-63-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,5,3,8 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 225382-63:
(8*2)+(7*2)+(6*5)+(5*3)+(4*8)+(3*2)+(2*6)+(1*3)=128
128 % 10 = 8
So 225382-63-8 is a valid CAS Registry Number.

225382-63-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(3-methylimidazol-4-yl)-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine

1.2 Other means of identification

Product number -
Other names 2-(3-Methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl-(2-methyl-1H-indol-5-yl)-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:225382-63-8 SDS

225382-63-8Downstream Products

225382-63-8Relevant articles and documents

Cross-coupling methods for the large-scale preparation of an imidazole - Thienopyridine: Synthesis of [2-(3-methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl] -(2-methyl-1H-indol-5-yl)-amine

Ragan,Raggon,Hill,Jones,McDermott,Munchhof,Marx,Casavant,Cooper,Doty,Lu

, p. 676 - 683 (2013/09/05)

The multihundred-gram synthesis of [2-(3-methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl] -(2-methyl-1H-indol-5-yl)-amine (1) is described utilizing a Stille cross-coupling of an iodothienopyridine (3) with 5-(tributylstannyl)-1-methylimidazole (11). Several cross-coupling methods were evaluated for the conversion of thienopyridine 3 to imidazole - thienopyridine 2, but only two were effective: the Stille coupling and a Negishi cross-coupling of the organozinc reagent derived from 2-(tertbutyldimethylsilyl)-1-methylimidazole and iodothienopyridine (3). The latter procedure worked well on laboratory scale (50 g), but was capricious upon scale-up. The issues with scale-up of an organostannane reagent are discussed, including control and analysis of organotin levels.

Thienopyrimidine and thienopyridine derivatives useful as anticancer agents

-

, (2008/06/13)

The invention relates to compounds of the formulas 1 and 2 and to pharmaceutically acceptable salts and hydrates thereof, wherein X1, R1, R2and R11are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formulas 1 and 2 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formulas 1 and 2.

Thiophene derivatives useful as anticancer agents

-

, (2008/06/13)

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R1, R2 and R11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

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