7570-49-2

Basic information

• Product Name: 5-AMINO-2-METHYLINDOLE
• Synonyms: 2-METHYL-1H-INDOL-5-AMINE;5-AMINO-2-METHYLINDOLE;5-AMINO-2-METHYLINDOL 97%;5-Amino-2-methylindole 95%;5-Amino-2-methylindole,95%;5-Amino-2-methylindole,98%;2-Methylindol-5-ylamine;5-Amino-2-methyl-1H-indole 95%
• CAS NO: 7570-49-2
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.19
• Product Categories: Indole;Indoles;Simple Indoles;Building Blocks;Heterocyclic Building Blocks;Building Blocks;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 7570-49-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 153-157 °C(lit.)
• Boiling Point: 255.81°C (rough estimate)
• Flash Point: 197.1 °C
• Appearance: brown crystalline powder or chunks
• Density: 1.0976 (rough estimate)
• Vapor Pressure: 2.76E-05mmHg at 25°C
• Refractive Index: 1.5600 (estimate)
• Storage Temp.: Freezer
• PKA: 17.97±0.30(Predicted)
• Sensitive: Stench
• CAS DataBase Reference: 5-AMINO-2-METHYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-METHYLINDOLE(7570-49-2)
• EPA Substance Registry System: 5-AMINO-2-METHYLINDOLE(7570-49-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 7570-49-2(Hazardous Substances Data)

Usage

Chemical Properties

brown crystalline powder or chunks

Uses

Different sources of media describe the Uses of 7570-49-2 differently. You can refer to the following data:
1. Reactant for preparation of:? ;Cytotoxic and antimitotic agents1? ;Potential antimicrobial aminoketones2? ;Inhibitors of monoamine oxidase (MAO)3? ;Protein kinase c theta (PKCθ) inhibitors4? ;Factor Xa inhibitors5? ;Inhibitors of vascular endothelial growth factor type 2 (VEGFR-2)6? ;Demethylasterriquinone B1receptor ligands7
2. Reactant for preparation of:Cytotoxic and antimitotic agentsPotential antimicrobial aminoketonesInhibitors of monoamine oxidase (MAO)Protein kinase c theta (PKCθ) inhibitorsFactor Xa inhibitorsInhibitors of vascular endothelial growth factor type 2 (VEGFR-2)Demethylasterriquinone B1receptor ligands

InChI:InChI=1/C9H10N2/c1-6-4-7-5-8(10)2-3-9(7)11-6/h2-5,11H,10H2,1H3

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 115210-54-3 2-methyl-5-nitroindoline 
• 438187-35-0 2-iodo-N¹,N⁴-di[(E)-phenylmethylidene]-benzene-1,4-diamine 
• 69951-01-5 2-iodo-1,4-phenylenediamine 
• 6293-83-0 2-iodo-4-nitrophenylamine 
• 438187-37-2 2-(2-methoxy-2-propenyl)-N¹,N⁴-di[(E)-phenylmethylidene]-benzene-1,4-diamine 
• 500730-25-6 N',N',N''',N'''-tetramethyl-N,N''-[(1-acetyl-2-oxo-propyl)-p-phenylene]-bis-sulfamide 
• 500730-27-8 N'-(3-acetyl-2-methyl-indol-5-yl)-N,N-dimethyl-sulfamide 
• 7570-47-0 5-nitro-2-methylindole 

Downstream Products

• 132515-37-8 N-(2-methyl-1H-indol-5-yl)benzamide 
• 686747-17-1 3-chloro-2-methyl-N-(2-methyl-1H-indol-5-yl)benzenesulphonamide 
• 865375-68-4 2,4-dichloro-N-(2-methyl-1H-indol-5-yl)-benzenesulfonamide 
• 869188-27-2 4-fluoro-N-(2-methyl-1H-indol-5-yl)-3-trifluoromethyl-benzamide 
• 225382-63-8 [2-(3-Methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine 
• 225382-64-9 2-{1-Methyl-5-[7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-1H-imidazol-2-yl}-propan-2-ol 
• 225382-65-0 [2-(1-Methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine 
• 477875-08-4 {2-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-thieno[3,2-b]pyridin-7-yl}-(2-methyl-1H-indol-5-yl)-amine 
• 1160918-74-0 4-[(2-methyl-1H-indol-5-yl)amino]-5-[(E)-2-phenylvinyl]nicotinonitrile 
• 1207835-09-3 2-(2-methyl-1H-5-indolylamino)benzoic acid 
• 1207835-10-6 5-methoxy-2-(2-methyl-1H-5-indolylamino)benzoic acid 

Relevant articles and documents

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Palladium nanoparticles stabilized by aqueous vesicles self-assembled from a PEGylated surfactant ionic liquid for the chemoselective reduction of nitroarenes

Vesicles self-assembled from an aqueous PEGylated surfactant ionic liquid solution can be applied for stabilizing palladium nanoparticles, which prove to be an efficient catalytic system for chemoselective hydrogen transfer of nitroarenes using hydrazine hydrate as a hydrogen source. The particle sizes of vesicles are decreased with the increase of ionic liquid's concentrations and relatively small particle sizes are beneficial to the reduction. Moreover, the aqueous catalytic system still stays in reactor by simple extraction, and is reused without further treatment.

Preparation of Polyfunctional Heterocycles Using Highly Functionalized Aminated Arylmagnesium Reagents as Versatile Scaffolds

(Equation Presented) Functionalized Grignard reagents, derived from readily available o-iodoaniline derivatives and obtained via a straightforward iodine-magnesium exchange, can be used to prepare a wide range of polyfunctional indoles, quinolines, and quinazolinones.