- AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF
-
Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.
- -
-
Page/Page column 98
(2010/04/25)
-
- Side chain hydroxylation of aromatic compounds by fungi. 1. Products and stereochemistry
-
The fungus Mortierella isabellina can convert ethylbenzene and a number of para-substituted derivatives to the corresponding optically active 1-phenylethanols with enantiomeric excess between 5 and 40percent and chemical yields up to 45percent. 2-Ethylnaphthalene, 2-ethylthiophene, and n-propylbenzene were similarly converted, as were the bicyclic compounds indane and tetraline.In most cases, the R absolute configuration of product predominated.The fungi Cunninghamella echinulata var. elegans and Helminthosporium species are also capable of performing some of these transformations.M. isabellina and C. elegans also produce 2-phenylethanols as products in some cases.The highest enantiomeric excesses during benzylic hydroxylation were obtained with Helminthosporium and are attributable, at least in part, to further stereoselective oxidation of the alcohol.Cross induction experiments with M. isabellina indicate that the same enzyme may be responsible for the benzylic hydroxylation of ethylbenzene, 2-ethylthiophene, and 2-ethylnaphthalene.
- Holland, Herbert L.,Bergen, Eleanor J.,Chenchaiah, P. Chinna,Khan, Shaheer H.,Munoz, Benito,et al.
-
p. 502 - 507
(2007/10/02)
-
- Kinetics of Hydrolysis of Some Acid Succinates in Water
-
The kinetics of hydrolysis of 1-phenylethyl hydrogen succinate and its p-alkyl (Me, Et), p-methoxy and p-halogen (F, Cl, Br) derivatives has been studied in water.The activation parameters are normal for a BAL 1 mechanism, except for the chloro and bromo derivatives.The Brown-Okomoto equation has also been applied to the present case.
- Saramma, K.,Thankamma, A.
-
p. 904 - 905
(2007/10/02)
-