Vicarious Nucleophilic Chloromethylation of Nitroaromatics
Nitroaromatics substituted with electron-acceptor or electron-donor groups undergo vicarious nucleophilic substitution with the lithium salt of dichloromethane to provide chloromethyl-substituted nitroaromatics in good to high yields. The methodology represents a new strategy for the synthesis of benzyl chlorides.
Khutorianskyi, Viktor V.,Klepetá?ová, Blanka,Beier
supporting information
p. 5443 - 5446
(2019/07/03)
Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis
An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and α,β-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities.