226880-86-0

Basic information

• Product Name: (R)-N-BOC-3-THIENYLALANINE
• Synonyms: BOC-3-D-ALA(3-THIENYL)-OH DCHA;BOC-BETA-(3-THIENYL)-D-ALANINE DICYCLOHEXYLAMMONIUM SALT;BOC-D-(3)THG-OH;BOC-D-3-THIENYLALANINE-DCHA;BOC-D-3-THIENYLALANINE DCHA SALT;BOC-D-ALA(3-THIENYL)-OH DCHA;BOC-D-(3-THIENYL)GLY-OH;BOC-3-(3-THIENYL)-D-ALANINE DICYCLOHEXYLAMINE SALT
• CAS NO: 226880-86-0
• Molecular Formula: C12H17NO4S
• Molecular Weight: 271.33
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Amino Acid Derivatives;a-amino
• Mol File: 226880-86-0.mol

Chemical Properties

• Boiling Point: 431.511 °C at 760 mmHg
• Flash Point: 214.771 °C
• Appearance: dark yellow to light brown chunks
• Density: 1.2791 (rough estimate)
• Vapor Pressure: 1.67E-15mmHg at 25°C
• Refractive Index: 1.6280 (estimate)
• Storage Temp.: Store at 0-5°C
• PKA: 3.85±0.10(Predicted)
• CAS DataBase Reference: (R)-N-BOC-3-THIENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-BOC-3-THIENYLALANINE(226880-86-0)
• EPA Substance Registry System: (R)-N-BOC-3-THIENYLALANINE(226880-86-0)

Safety Data

• Hazard Codes: Xi
• Statements: 24/25
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 226880-86-0(Hazardous Substances Data)

Usage

Chemical Properties

dark yellow to light brown chunks

InChI:InChI=1/C12H17NO4S.C12H23N/c1-12(2,3)17-11(16)13-9(10(14)15)6-8-4-5-18-7-8;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h4-5,7,9H,6H2,1-3H3,(H,13,16)(H,14,15);11-13H,1-10H2/t9-;/m0./s1

Upstream product

• 123-91-1 1,4-dioxane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3685-51-6 3-(thien-3-yl)-DL-alanine 
• 67206-08-0 2-acetylamino-3-[3]thienyl-propionic acid 

Relevant articles and documents

INHIBITORS OF AKT ACTIVITY

Invented are novel substituted pyridine compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Peptidyl inhibitors of viral proteases

The invention provides amino acid derivatives of the formula STR1 wherein E represents CHO or B(OH)2 ; R1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl; R2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; and R3 represents hydrogen or lower alkyl; or R2 and R3 together represent di- or trimethylene optionally substituted by hydroxy; R4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl; R5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl; R6 represents hydrogen or lower alkyl; R7 represent lower alkyl (optionally substituted by hydroxy, carboxy, aryl or lower cycloalkyl) or lower cycloalkyl; R8 represents lower alkyl optionally substituted by hydroxy, carboxy or aryl; and R9 represents lower alkylcarbonyl, carboxy-lower alkylcarbonyl, arylcarbonyl, lower alkylsulphonyl, arylsulphonyl, lower alkoxycarbonyl or aryl-lower al koxycarbonyl, and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.

Studies on Cyclic Dipeptides, I: Aryl Modifications of cyclo-[Phe-His]

Seven new cyclic dipeptides have been synthesized and tested for their applicability as tools to elucidate the mechanism of formation of mandelonitrile with (SS)-cyclo-[Phe-His] type catalysts. Conformational analyses based on 1H NMR spectra are presented for all prepared cyclic dipeptides.