A straightforward synthetic approach for roxindole
A concise synthetic approach to the dopamine autoreceptor agonist roxindole 1 has been devised. The key step in the novel route is the addition of succinic anhydride to 5-methoxyindolylmagnesium bromide, which circumvents the cumbersome construction of th
Lange, Jos H. M.,De Jong, Johannes C.,Sanders, Hans J.,Visser, Geb M.,Kruse, Chris G.