Bioorganic and Medicinal Chemistry Letters p. 1055 - 1056 (1999)
Update date:2022-07-31
Topics:
Lange, Jos H. M.
De Jong, Johannes C.
Sanders, Hans J.
Visser, Geb M.
Kruse, Chris G.
A concise synthetic approach to the dopamine autoreceptor agonist roxindole 1 has been devised. The key step in the novel route is the addition of succinic anhydride to 5-methoxyindolylmagnesium bromide, which circumvents the cumbersome construction of th
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