228251-24-9

Basic information

• Product Name: 5-BROMO-2-CHLORO-PYRIDINE-3-CARBALDEHYDE
• Synonyms: 5-bromo-2-chloronicotinaldehyde (en);5-Bromo-2-chloropyridine-3-carboxaldehyde, 5-Bromo-2-chloro-3-formylpyridine;5-Bromo-2-chloro-3-pyridinecarboxaldehyde;5-BroMo-2-chloro-pyridine-3-carbaldehyde;3-Pyridinecarboxaldehyde,5-broMo-2-chloro-
• CAS NO: 228251-24-9
• Molecular Formula: C₆H₃BrClNO
• Molecular Weight: 220.46
• Mol File: 228251-24-9.mol

Chemical Properties

• Boiling Point: 278.003 °C at 760 mmHg
• Flash Point: 121.932 °C
• Appearance: /
• Density: 1.8 g/cm³
• Vapor Pressure: 0.00437mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.75±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-2-CHLORO-PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLORO-PYRIDINE-3-CARBALDEHYDE(228251-24-9)
• EPA Substance Registry System: 5-BROMO-2-CHLORO-PYRIDINE-3-CARBALDEHYDE(228251-24-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 228251-24-9(Hazardous Substances Data)

Usage

Uses

Used in Research and Development:
5-Bromo-2-chloro-pyridine-3-carbaldehyde is used as a synthetic chemical intermediate for the preparation of more complex compounds. It plays a crucial role in the synthesis of potential drug candidates, contributing to the advancement of pharmaceutical research.
Used in Material Science:
In the field of material science, 5-Bromo-2-chloro-pyridine-3-carbaldehyde is employed as a building block for the development of new materials with specific properties. Its unique structure and reactivity make it a valuable component in the creation of novel materials with potential applications in various industries.
Safety Considerations:
Due to its chemical nature, 5-Bromo-2-chloro-pyridine-3-carbaldehyde should be handled with appropriate protective measures. It may present unknown health hazards if not properly managed, emphasizing the importance of safety protocols in its use and manipulation.

InChI:InChI=1/C6H3BrClNO/c7-5-1-4(3-10)6(8)9-2-5/h1-3H

Upstream product

• 78686-79-0 methyl 2-chloro-5-bromonicotinate 
• 29241-65-4 5-bromo-2-chloronicotinic acid 
• 742100-75-0 (5-bromo-2-chloro-pyridin-3-yl)-methanol 
• 885223-63-2 5-bromo-2-chloro-N-methoxy-N-methylnicotinamide 

Downstream Products

• 1111638-41-5 1-(5-bromo-2-chloropyridin-3-yl)ethanol 
• 1332392-76-3 5-bromo-2-chloro-3-(difluoromethyl)pyridine 
• 928653-74-1 5-bromo-2-chloro-3-(dimethoxymethyl)pyridine 

Relevant articles and documents

LPA RECEPTOR ANTAGONISTS AND USES THEREOF

The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non alcoholic steatohepatitis (NASH).

PLASMA KALLIKREIN INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS

Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disc

CERTAIN PROTEIN KINASE INHIBITORS

Provided are certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use therefor.

NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS

The present invention describes new pyrazolo-pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein, R1 is halogen, cyano, or C1-C3alkyl optionally substituted by halogen; R2 is C1-C6alkyl optionally substituted one or more times by C1-C6alkyl, C2-C6alkenyl, hydroxyl, N,N-di-C1-C6alkyl amino, N-mono-C1-C6alkyl amino, O-Rg, Rg, phenyl, or by C1-C6alkoxy wherein said alkoxy again may optionally be substituted by C1-C6alkoxy, N,N-di-C1-C6alkyl amino, Rg or phenyl; C3-C6cycloalkyl optionally substituted by C1-C6alkyl, N,N-di-C1-C6alkyl amino or C1-C6alkoxy-C1-C6alkyl, and/or two of said optional substituents together with the atoms to which they are bound may form an annulated or spirocyclic 4 - 6 membered saturated heterocyclic ring comprising 1 - 2 O atoms; phenyl optionally substituted by C1-C6alkoxy; a 5 - 6 membered heteroaryl ring having 1 to 3 heteroatoms selected from N and O said ring being optionally substituted by C1-C6alkyl which may be optionally substituted by amino or hydroxy; Rg; or N,N-di-C1-C6alkyl amino carbonyl; and R is phenyl independently substituted two or more times by Ra, 2-pyridyl independently substituted one or more times by Rb, 3-pyridyl independently substituted one or more times by Rc, or 4-pyridyl independently substituted one or more times by Rd; which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

SPIRO CONDENSED BARBITURIC ACID DERIVATIVES FOR USE AS ANTIBACTERIAL

In one aspect, the present invention relates to compounds of Formula (I): to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to method for their preparation.

PYRAZOLE COMPOUNDS

The present invention is directed to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

ACRYLAMIDE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

A compound represented by the formula: wherein R1 is a 5- or 6-membered ring; R3 is a hydrogen atom, a lower alkyl group or a lower alkoxy group; R7 and R8 are each a hydrogen atom or a lower alkyl group; Z1 is another 5- or 6-membered aromatic ring; Z2 is a group represented by -Z2a-W1-Z2b- [wherein Z2a and Z2b are each O, S(O)m (wherein m is 0, 1 or 2), an imino group or a bond, and W1 is an alkylene chain]; X is CR (wherein R is a hydrogen atom, a lower alkyl group, a lower alkoxy group, an acyl group, or R and adjacent R4 may form a 5- or 6-membered alicyclic heterocyclic group) or N; R4 is NR5R6 (wherein R5 and R6 are each a hydrogen atom, a hydrocarbon group, a heterocyclic group or an acyl group), or R5 and R6 are bonded to each other to form a heterocyclic group of NR5R6; and R2 is (1) an amino group which may be a quaternary ammonium or oxide, (2) a nitrogen-containing heterocyclic group which may contain a sulfur atom or an oxygen atom as the ring-constituting atom, in which the nitrogen atom may be converted to a quaternary ammonium or an oxide, or the like; or a salt thereof. The compound has excellent CCR5 antagonistic activity and thus is useful as a prophylactic and/or therapeutic medicine for HIV infection into human peripheral blood monocyte, especially for AIDS.