742100-75-0

Basic information

• Product Name: (5-BROMO-2-CHLORO-PYRIDIN-3-YL)-METHANOL
• Synonyms: (5-BROMO-2-CHLORO-3-PYRIDINYL)METHANOL;(5-BROMO-2-CHLORO-PYRIDIN-3-YL)-METHANOL;5-Bromo-2-chloro-3-(hydroxymethyl)pyridine;(5-bromo-2-chloro-3-pyridinyl)methanol (en);(5-Bromo-2-chloro-3-pyridyl)methanol
• CAS NO: 742100-75-0
• Molecular Formula: C₆H₅BrClNO
• Molecular Weight: 222.467
• Mol File: 742100-75-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 76-78
• Boiling Point: 320.5 °C at 760 mmHg
• Flash Point: 147.6 °C
• Appearance: /
• Density: 1.785 g/cm³
• Vapor Pressure: 0.000131mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.62±0.10(Predicted)
• CAS DataBase Reference: (5-BROMO-2-CHLORO-PYRIDIN-3-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (5-BROMO-2-CHLORO-PYRIDIN-3-YL)-METHANOL(742100-75-0)
• EPA Substance Registry System: (5-BROMO-2-CHLORO-PYRIDIN-3-YL)-METHANOL(742100-75-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 742100-75-0(Hazardous Substances Data)

Usage

General Description

(5-BROMO-2-CHLORO-PYRIDIN-3-YL)-METHANOL is a chemical compound with the molecular formula C6H5BrClNO. It contains a pyridine ring with a bromine atom at position 5 and a chlorine atom at position 2. Additionally, it has a methanol group attached to the pyridine ring. (5-BROMO-2-CHLORO-PYRIDIN-3-YL)-METHANOL is commonly used in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a versatile building block for creating more complex organic molecules. Its applications range from drug development to crop protection, and it is an important intermediate in the manufacturing of various products in the chemical industry.

InChI:InChI=1/C6H5BrClNO/c7-5-1-4(3-10)6(8)9-2-5/h1-2,10H,3H2

Upstream product

• 78686-86-9 5-bromo-2-chloro-pyridine-3-carbonyl chloride 
• 29241-65-4 5-bromo-2-chloronicotinic acid 
• 543-27-1 isobutyl chloroformate 
• 78686-79-0 methyl 2-chloro-5-bromonicotinate 
• 104612-36-4 5-bromo-2-hydroxynicotinic acid 
• 609-71-2 2-hydroxy-3-carboxypyridine 

Downstream Products

• 1211581-73-5 1-(5-bromo-2-chloropyridin-3-yl)methanamine 
• 1309778-62-8 N-(6-{6-chloro-5-[(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide 
• 1332392-76-3 5-bromo-2-chloro-3-(difluoromethyl)pyridine 
• 1309778-66-2 N-(6-{6-chloro-5-[fluoro(phenylsulfonyl)methyl]-3-pyridinyl}-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide 
• 1309778-77-5 5-bromo-2-chloro-3-[fluoro(phenylsulfonyl)methyl]pyridine 
• 1309778-76-4 5-bromo-2-chloro-3-((phenylsulfonyl)methyl)pyridine 
• 228251-24-9 5-bromo-2-chloropyridine-3-carbaldehyde 
• 917473-30-4 8-(4-methoxy-phenyl)-6-methyl-3-(4-piperidin-1-yl-butyl)-5,6,7,8-tetrahydro-[1,6]-naphthyridine 
• 917473-28-0 8-(4-methoxy-phenyl)-6-methyl-3-(4-piperidin-1-yl-but-1-ynyl)-5,6,7,8-tetrahydro-[1,6]naphthyridine 
• 917473-42-8 3-bromo-8-(4-methoxy-phenyl)-6-methyl-5,6,7,8-tetrahydro-[1,6]naphthyridine 
• 917473-41-7 3-bromo-8-(4-methoxy-phenyl)-6-methyl-5,8-dihydro-6H-[1,6]naphthyridin-7-one 
• 917473-40-6 N-(5-bromo-2-chloro-pyridin-3-ylmethyl)-2-(4-methoxy-phenyl)-N-methyl-acetamide 

Relevant articles and documents

SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof.

NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS

The present invention describes new pyrazolo-pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein, R1 is halogen, cyano, or C1-C3alkyl optionally substituted by halogen; R2 is C1-C6alkyl optionally substituted one or more times by C1-C6alkyl, C2-C6alkenyl, hydroxyl, N,N-di-C1-C6alkyl amino, N-mono-C1-C6alkyl amino, O-Rg, Rg, phenyl, or by C1-C6alkoxy wherein said alkoxy again may optionally be substituted by C1-C6alkoxy, N,N-di-C1-C6alkyl amino, Rg or phenyl; C3-C6cycloalkyl optionally substituted by C1-C6alkyl, N,N-di-C1-C6alkyl amino or C1-C6alkoxy-C1-C6alkyl, and/or two of said optional substituents together with the atoms to which they are bound may form an annulated or spirocyclic 4 - 6 membered saturated heterocyclic ring comprising 1 - 2 O atoms; phenyl optionally substituted by C1-C6alkoxy; a 5 - 6 membered heteroaryl ring having 1 to 3 heteroatoms selected from N and O said ring being optionally substituted by C1-C6alkyl which may be optionally substituted by amino or hydroxy; Rg; or N,N-di-C1-C6alkyl amino carbonyl; and R is phenyl independently substituted two or more times by Ra, 2-pyridyl independently substituted one or more times by Rb, 3-pyridyl independently substituted one or more times by Rc, or 4-pyridyl independently substituted one or more times by Rd; which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors

A series of novel tetrahydronaphthyridine-based histamine H3 ligands that have serotonin reuptake transporter inhibitor activity is described. The 1,2,3,4-tetrahydro-2,6-naphthyridine scaffold is assembled via the addition of a nitrostyrene to a metalated pyridine followed by reduction and cyclization to form the naphthyridine. In vitro biological data for these novel compounds are discussed.