22907-30-8Relevant articles and documents
Self-Boosting Catalytic Nanoreactors Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis
Anraku, Yasutaka,Kataoka, Kazunori,Li, Junjie
, p. 13526 - 13530 (2020)
Synthetic polymer vesicles spur novel strategies for producing intelligent nanodevices with precise and specific functions. Engineering vesicular nanodevices with tunable permeability by a general platform without involving trade-offs between structural integrity, flexibility, and functionality remains challenging. Herein, we present a general strategy to construct responsive nanoreactors based on polyion complex vesicles by integrating stimuli-responsive linkers into a crosslinking membrane network. The formulated ROS-responsive nanoreactor with self-boosting catalytic glucose oxidation could protect glucose oxidase (GOD) to achieve cytocidal function by oxidative stress induction and glucose starvation, which is ascribed to stimuli-responsive vesicle expansion without fracture and size-selective cargo release behavior. The GOD-loaded therapeutic nanoreactor induced an immunostimulatory form of cell death by pyroptosis, which has the great potential to prime anti-tumor immune responses.
Amphiphilic nanocage with active oxygen sensitivity, preparation method and application thereof
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Paragraph 0040-0044, (2020/04/29)
The invention discloses an amphiphilic nanocage with active oxygen sensitivity, a preparation method and application thereof. The amphiphilic nanocage is prepared by the steps of: firstly, forming a nanoemulsion from amphiphilic polybetaine and a thioketal bond-containing small molecular compound with active oxygen sensitivity, and then carrying out reaction under the action of an initiator. The amphiphilic nanocage has amphipathy, high stability, also has active oxygen sensitivity, and can be disintegrated under the action of active oxygen. When the nanocage is a carrier complex protein, theprotein can be included in the nanocage, the protein stability is improved, and transportation of the protein is utilized; after the protein-loaded nanoparticles enter the body, under the action of active oxygen, the external nanocage is disintegrated, and internal protein is released, thus playing a role at a focus part.
A reactive oxygen species-responsive dendrimer with low cytotoxicity for efficient and targeted gene delivery
Wang, Yueqi,Li, Changjian,Du, Libo,Liu, Yang
supporting information, (2019/04/17)
Nonviral vectors have been attracting more attention for several advantages in gene delivery and the development of nonviral gene carriers with high delivery efficiency and low cytotoxicity has long been a key project. Starburst polyamidoamine dendrimers are a class of synthetic polymers with unique structural and physical characteristics. However, when they are used as gene carrier, the gene transfection efficiency is not satisfactory. Herein, a novel thioketal-core polyamidoamine dendrimer (i.e., ROS-PAMAM) was synthesized and characterized. Compared to ethylenediamine-core dendrimers or widely used cationic polymers of polyetherimide, ROS-PAMAM showed lower cytotoxicity. Moreover, ROS-PAMAM demonstrated reactive oxygen species responsive characteristics, which can facilitate the release of siRNA in the tumor microenvironment. In vitro gene transfection experiments based on A549 cells confirmed that siRNA/ROS-PAMAM exhibits high gene transfection efficiency. It is concluded that ROS-PAMAM shows great potential as a generalizable vehicle for gene therapy applications.
PHARMACEUTICAL COMPOSITIONS CONTAINING POLYROTAXANES
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Page/Page column 15, (2019/10/23)
Disclosed herein are a polyrotaxane conjugated metal chelators and selectively cleavable linkers. The compositions have prolonged plasma residence time, and upon contact with the appropriate chemical environment, are cleaved and then renally and fecally cleared.
A reactive oxygen species (ROS)-responsive polymer for safe, efficient, and targeted gene delivery in cancer cells
Shim, Min Suk,Xia, Younan
supporting information, p. 6926 - 6929 (2013/07/26)
Stimuli-responsive release: The high levels of reactive oxygen species (ROS) in prostate cancer cells can be exploited to trigger cancer-targeted gene delivery. A ROS-responsive thioketal-based cationic polymer was synthesized and functionalization with a cancer-targeting peptide led to selective and enhanced gene transfection in prostate cancer cells (see scheme). Copyright
Radioprotective germanium dithioacetals of cysteamine and methylcysteamine
Fatome,Sentenac-Roumanou,Lion,et al.
, p. 119 - 122 (2007/10/02)
Ten germanium derivatives of cysteamine and methylcysteamine have been synthesized. Their radioprotective activity is higher that that of their thioacetal isologs. The toxicity of these germanium derivatives is higher than or close to the toxicity of thei