67-64-1

Basic information

• Product Name: Acetone
• Synonyms: Dimethyl ketone;Dimethylformaldehyde;NSC 135802;Propanone;Pyroacetic ether;beta-Ketopropane;Acetone(8CI);Methyl ketone (6CI);2-Propanone
• CAS NO: 67-64-1
• Molecular Formula: C₃H₆O
• Molecular Weight: 58.07914
• EINECS: 200-662-2
• Mol File: 67-64-1.mol
• Article Data: 2732

Chemical Properties

• Melting Point: -95℃
• Boiling Point: 56-57 °C, 329-330 K, 133-134 °F
• Flash Point: -17 °C
• Appearance: clear colorless liquid
• Density: 0.773 g/cm³
• Vapor Density: 2
• Refractive Index: 1.3585
• Water Solubility: soluble
• CAS DataBase Reference: Acetone(CAS DataBase Reference)
• NIST Chemistry Reference: Acetone(67-64-1)
• EPA Substance Registry System: Acetone(67-64-1)

Safety Data

• Hazard Codes: F:Flammable;;
• Statements: R11:; R36:; R66:; R67:
• Safety Statements: S16:; S26:; S9:
• Hazardous Substances Data: 67-64-1(Hazardous Substances Data)

Usage

Safety Profile

Moderately toxic by various routes.A skin and severe eye irritant. Human systemic effects byinhalation: changes in EEG, changes in carbohydratemetabolism, nasal effects, conjunctiva irritation, respiratorysystem effects, nausea and vomiting, and muscl

InChI:InChI=1/C3H6O/c1-3(2)4/h1-2H3

Synthetic route

isopropyl alcohol (67-63-0) → acetone (67-64-1)

Conditions	Yield
With trans-4L1(O)2>ClO4 In acetonitrile at 25℃; for 7h; stoicheiometric oxidation ( electrochemical oxidation in a non-aqueous medium (acetonitrile), an Ag-AgNO3 reference electrode;	100%
With C19H20N3O2Ru(2+)*2F6P(1-) In aq. buffer at 24.84℃; for 1h; pH=1.8; Thermodynamic data; Activation energy; Reagent/catalyst;	100%
With tert-butylethylene; C32H52ClIrP2; sodium t-butanolate at 200℃; for 2h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Glovebox;	100%

pyridine (110-86-1) + tert-butylsulfinyl chloride (31562-43-3) → pyridine hydrochloride (628-13-7) + acetone (67-64-1) + pyridinium tert-butylsulfonate + tert-butyl alcohol (75-65-0)

Conditions	Yield
With tert.-butylhydroperoxide In chloroform at 20℃; for 2h; Further byproducts given;	A 100% B 20% C 40% D 55%

2,3-dimethyl-2,3-butane diol (76-09-5) → acetone (67-64-1)

Conditions	Yield
With N-Bromosuccinimide; water; potassium carbonate; triphenylbismuthane In acetonitrile for 2h;	100%
With tert.-butylhydroperoxide; bis(acetylacetonato)dioxidomolybdenum(VI) In chlorobenzene at 60℃; for 24h;	99%
With tert.-butylhydroperoxide; chromium tetra(tert-butoxide) In benzene at 20℃; for 24h;	90%

5-cyclopentylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (3968-30-7) → butatriene (2873-50-9) + ethene (74-85-1) + carbon dioxide (124-38-9) + cyclohexa-1,3-diene (1165952-91-9) + acetone (67-64-1) + benzene (71-43-2)

Conditions	Yield
With variation of temp. at 550℃; Product distribution;	A 4% B 11.9% C 100% D 39.2% E 101.9 % F 3.3%

cyclohexane (110-82-7) + perpentene-4 oate de tertiobutyle (84210-61-7) → cyclohexylcyclohexane (92-51-3) + butylcyclohexane (1678-93-9) + cyclohexyl-5 pentanolide-4 (96009-79-9) + acetone (67-64-1) + 5-methyl-dihydro-furan-2-one (108-29-2) + tert-butyl alcohol (75-65-0)

Conditions	Yield
at 120℃; for 4h; Product distribution; Mechanism; different ratios of reactant, reactants, reaction times and temperatures;	A 5% B 5% C 35% D n/a E 1% F 100%

cyclohexane (110-82-7) + 1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindol-2-yloxoyl radical (80037-90-7) + 2-(t-butylazo)prop-2-yl hydroperoxide (37421-16-2) → 2-cyclohexyloxy-1,1,3,3-tetramethyl-2,3-dihydro-1H-isoindole (89482-40-6) + 2-tert-butoxy-1,1,3,3-tetramethylisoindoline (93524-81-3) + acetone (67-64-1) + isobutene (115-11-7)

Conditions	Yield
at 70℃; for 17h; Mechanism; Rate constant; Thermodynamic data; var. of nitroxide, solvent, temp., EA, ΔH(excit.), ΔS(excit.);	A 96% B 82% C 100% D 15%

2-(octylsulfonyl)ethyl tert-butyl peroxide (83073-73-8) → methane (34557-54-5) + 2-hydroxyethyl octyl sulfone (20466-47-1) + acetone (67-64-1) + tert-butyl alcohol (75-65-0)

Conditions	Yield
In various solvent(s) at 145℃; Rate constant; Thermodynamic data; E(act.);	A n/a B 100% C n/a D n/a

H-Dmt-Gly-Gly-Ala-OH trifluoroacetate salt (120711-57-1) → H-Cys-Gly-Gly-Ala-OH (120711-58-2) + acetone (67-64-1)

Conditions	Yield
In ethanol; water Heating;	A 100% B n/a

Isopropenyl acetate (108-22-5) + phenol (108-95-2) → acetone (67-64-1) + Phenyl acetate (122-79-2)

Conditions	Yield
With potassium carbonate; Aliquat 336 In neat (no solvent) at 70℃; for 0.5h;	A n/a B 100%
With potassium carbonate; Aliquat 336 In neat (no solvent) at 70℃; for 0.5h; Product distribution;	A n/a B 100%

2,2-dimethyl-5-(phenyl-λ3-iodaneylidene)-1,3-dioxane-4,6-dione (34107-52-3) → cycl-isopropylidene malonate (2033-24-1) + iodobenzene (591-50-4) + acetone (67-64-1)

Conditions	Yield
With dirhodium tetraacetate In dichloromethane at 20℃; Product distribution;	A 33% B 100% C 5%

dimethyl(2,2'-bipyridyl)nickel(II) → NiCH3(N(CO)2C6H4)(P(C2H5)3)2 (67552-35-6, 79390-59-3, 79042-98-1) + Ni(CO)2(2,2'-bipyridine) (14917-14-7) + acetone (67-64-1)

Conditions	Yield
In benzene-d6 40°C, 72 h;	A 100% B n/a C 33%

CpRe(CO)2(COCH3)(CH3) + triphenylphosphine (603-35-0) → (η5-C5H5)Re(CO)2(PPh3) + acetone (67-64-1)

Conditions	Yield
In 1,4-dioxane; benzene-d6 Kinetics; 100°C (10.25 h);	A 100% B 97%
In benzene-d6 Irradiation (UV/VIS);	A 55% B n/a

tetrachloromethane (56-23-5) + CpRe(CO)2(COCH3)(CH3) → tricarbonylcyclopentadienylrhenium + acetyl chloride (75-36-5) + dimethylglyoxal (431-03-8) + acetone (67-64-1)

Conditions	Yield
With CO In dichloromethane-d2 Irradiation (UV/VIS); 355-385 nm; 20 atm CO;;	A 100% B n/a C n/a D n/a

CpRe(CO)2(COCH3)(CH3) + 3,4-hexanedione (4437-51-8) → tricarbonylcyclopentadienylrhenium + 2,3-Pentanedione (600-14-6) + dimethylglyoxal (431-03-8) + acetone (67-64-1)

Conditions	Yield
With CO In benzene-d6 Irradiation (UV/VIS); 355-385 nm;;	A 100% B 68% C 34% D 10%

CpRe(CO)2(CH3)2 → tricarbonylcyclopentadienylrhenium + dimethylglyoxal (431-03-8) + acetone (67-64-1)

Conditions	Yield
With CO In dichloromethane-d2 Irradiation (UV/VIS); 20 atm CO;;	A 100% B 79% C 5%

CpRe(CO)2(COCH3)(CH3) → tricarbonylcyclopentadienylrhenium + dimethylglyoxal (431-03-8) + acetone (67-64-1)

Conditions	Yield
With carbon monoxide In dichloromethane-d2 Irradiation (UV/VIS); Irradiation of complex at 350-380 nm under 20 atm of CO in CD2Cl2 at 6-8°C;;	A 100% B 80% C 8%
With CO In 1,4-dioxane; dichloromethane-d2 Irradiation (UV/VIS); ca. 20 atm CO; 355-385 nm light, 22 min.;	A 100% B 78% C 6%

(3-(tert-butylperoxy)pentane-3yl)benzene → 1-phenyl-propan-1-one (93-55-0) + acetone (67-64-1) + tert-butyl alcohol (75-65-0)

Conditions	Yield
With air In [D3]acetonitrile at 22℃; for 1h; UV-irradiation; Inert atmosphere;	A 100% B 41.9% C 25.9%

4-amino-3-penten-2-one (1118-66-7) → acetone (67-64-1)

Conditions	Yield
at 250℃; for 0.666667h; Heating; Inert atmosphere;	99.76%

2,5-dimethyl-2,5-hexanediol (110-03-2) → Succinimide (123-56-8) + acetone (67-64-1)

Conditions	Yield
With N-iodo-succinimide In benzene for 0.916667h; Product distribution; Mechanism; Irradiation; varying reaction time;	A 88% B 99%

acetophenone (98-86-2) + isopropyl alcohol (67-63-0) → (S)-1-phenylethanol (1445-91-6) + acetone (67-64-1)

Conditions	Yield
With cis-[Ru(PPh2)(CH2)5PPh2(ampi)Cl2]; potassium hydroxide at 80℃; for 0.5h; Reagent/catalyst; Concentration; Schlenk technique;	A 99% B n/a
Stage #1: isopropyl alcohol With dichloro(1,5-cyclooctadiene)ruthenium(II); (R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanamine at 20℃; for 0.5h; Inert atmosphere; Stage #2: With potassium hydroxide for 0.5h; Inert atmosphere; Stage #3: acetophenone at 0℃; for 96h; Inert atmosphere; enantioselective reaction;	A 83% B n/a
With potassium hydroxide; oxalyl (1R,2R)-N,N'-bis[2-(amino)cyclohexyl]diamide; tris(triphenylphosphine)ruthenium(II) chloride at 20℃; for 24h; Product distribution; Further Variations:; Reagents;

9-fluorenone (486-25-9) + isopropyl alcohol (67-63-0) → 9-Fluorenol (1689-64-1) + acetone (67-64-1)

Conditions	Yield
With [RuCl2(triphenylphosphine)((6-((3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl)methylene)-p-tolyl-amine)]*0.5Et2O; potassium isopropoxide at 82℃; under 750.075 Torr; for 5.16667h; Inert atmosphere;	A 99% B n/a
With sodium hydroxide; RuCl2(PPh3)(iBu-BTP) at 82℃; under 750.075 Torr; for 9h;	A 97 % Chromat. B n/a

(H2O)5CrC(CH3)2OH(2+) → chromium (III) ion + acetone (67-64-1)

Conditions	Yield
With Fe(3+) In water; isopropyl alcohol Kinetics; byproducts: H(1+); excess of Fe(3+) in 1 M aq. i-PrOH at 24.8°C under N2 by controlled ionic strength;	A n/a B 99%

ethyl 2-benzoyl-6-methylhept-5-enoate → ethyl 2-phenylcyclopent-2-ene-1-carboxylate + acetone (67-64-1)

Conditions	Yield
With gold(III) chloride In 1,2-dichloro-ethane at 25℃; Reagent/catalyst; Solvent; Sealed tube;	A 99% B n/a
With N-iodo-succinimide In 1,2-dichloro-ethane at 20℃; for 24h; Reagent/catalyst;	A 66% B n/a

4-fluoro-2-(5-methylhex-4-en-1-yl)benzaldehyde → 3-fluoro-6,7-dihydro-5H-benzo[7]annulene + acetone (67-64-1)

Conditions	Yield
With gold(III) chloride In 1,2-dichloro-ethane at 25℃; Sealed tube;	A 99% B n/a

Cumene hydroperoxide (80-15-9) → acetone (67-64-1) + phenol (108-95-2)

Conditions	Yield
With iron(III) perchlorate In acetonitrile Product distribution; var. act.: CuClO4; var. solv.: CH2Cl2, toluene; var. conc.; determination of half life;	A 98.9% B 96.3%
With N-Phenyl-2-naphthylamine; cobalt(II) phthalocyanine In decalin at 40℃; Rate constant; Kinetics; var. temperatures, var. catalysts, var. solvents, without NA;
In chlorobenzene at 75℃; Kinetics; various phosphites;

isopropyl alcohol (67-63-0) → propene (187737-37-7) + acetone (67-64-1)

Conditions	Yield
6xSAlH (sulfated alumina) at 246.85℃; Product distribution; Further Variations:; Catalysts; atmospheric pressure;	A 98.4% B 1.6%
bismuth molybdate; bismuth molybdate at 190℃; Product distribution; with Bi2Mo2O9 (β-phase) catalyst;	A 12% B 88%
With cobalt ferrite; oxygen at 299.84℃; for 3h; Autoclave;	A 52% B 40%

tert.-butylhydroperoxide (75-91-2) + 2,2'-azinobis-(3-ethyl-2,3-dihydrobenzothiazole-6-sulphonate) diammonium salt (30931-67-0) → methanol (67-56-1) + formaldehyd (50-00-0) + C18H18N4O6S4(1+)*2H3N + acetone (67-64-1) + tert-butyl alcohol (75-65-0)

Conditions	Yield
Fe(III)T4MPyP In water at 30℃; Rate constant; Kinetics; Mechanism; the catalyst Fe(III)T4MPyP is 5,10,15,20-tetra(N-methyl-4-pyridyl)-porphyrinatoiron(III) pentachloride; pH 9.2; investigation of the dependence of velocity constant on ionic strength, pH and t-butyl hydroperoxide concentration;	A 3% B n/a C 72% D 4% E 98%

(4aRS,7aRS)-4a,7a-dihydro-3,3-dimethyl-6,7a-diphenyl-7H-cyclopenta<1,2-e><1,2,4>trioxine (87051-12-5) → (1RS,2RS)-1,4-diphenylcyclopent-3-en-1,2 diol (114390-60-2) + acetone (67-64-1)

Conditions	Yield
With acetic acid; zinc at 16℃; for 0.333333h;	A 98% B n/a

para-chloroacetophenone (99-91-2) + isopropyl alcohol (67-63-0) → 1-(p-chlorophenyl)ethyl alcohol (3391-10-4) + acetone (67-64-1)

Conditions	Yield
With C58H49ClN5P2Ru(1+)*Cl(1-); potassium isopropoxide at 82℃; for 0.00555556h; Inert atmosphere;	A 98% B n/a
With sodium hydroxide; RuCl2(PPh3)(iBu-BTP) at 82℃; under 750.075 Torr; for 30h;	A 89 % Chromat. B n/a
With [RuCl2(triphenylphosphine)((6-((3,5-dimethyl-pyrazol-1-yl)pyridin-2-yl)methylene)-p-tolyl-amine)]*0.5Et2O; potassium isopropoxide at 82℃; under 750.075 Torr; for 1.16667h; Inert atmosphere;	A 98 %Chromat. B n/a

NiMe2(PEt3)2 → (CO)2Ni(P(C2H5)3)2 (16787-33-0) + acetaldehyde (75-07-0) + dimethylglyoxal (431-03-8) + acetone (67-64-1)

Conditions	Yield
With carbon monoxide In diethyl ether Et2O soln. of Ni complex stirred under CO at -78°C for 0.2 h, warmed to room temp.; drying up; GLC anal.;	A n/a B 0% C 0% D 98%

styrene oxide (96-09-3) + acetone (67-64-1) → 2,2-dimethyl-4-phenyl-1,3-dioxolane (52129-03-0)

Conditions	Yield
With FeOx-pillared bentonite at 30℃; for 0.0833333h; Reagent/catalyst; Time; Temperature; Solvent;	100%
erbium(III) triflate at 20℃; for 0.5h;	99%
With trichloro(trifluoromethanesulfonato)titanium(IV); n-tetrabutylammonium hydroxide In water for 0.166667h; Ambient temperature;	98%

piperonal (120-57-0) + acetone (67-64-1) → (1E,4E)-1,5-bis(benzo[d][1,3]dioxol-5-yl)penta-1,4-dien-3-one (108439-88-9)

Conditions	Yield
With sodium hydroxide In ethanol for 0.00833333h; Irradiation;	100%
With sodium hydroxide In ethanol; water at 20℃;	85%
With sodium hydroxide In ethanol; water at 20℃; Aldol Addition;	79%

4-nitrobenzaldehdye (555-16-8) + acetone (67-64-1) → 1-(4-nitrophenyl)-1-hydroxy-3-butanone (88958-64-9, 88958-65-0, 97600-21-0, 57548-40-0)

Conditions	Yield
With Zn(2+)-(TyrOEt)2 In water at 40℃; for 24h; pH 7;	100%
With sodium hydroxide at 25℃; for 0.166667h;	100%
With Fe(OH)3/Fe3O4 at 50℃; for 3h;	99%

6-Chloropurine riboside (2004-06-0) + acetone (67-64-1) → 6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purine (39824-26-5)

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; for 3h;	100%
In perchloric acid for 3h; Ambient temperature;	94%
With perchloric acid at 25℃;	94%

cyclopenta-1,3-diene (542-92-7) + acetone (67-64-1) → 6,6'-dimethyl fulvene (2175-91-9)

Conditions	Yield
Stage #1: cyclopenta-1,3-diene; acetone With pyrrolidine In methanol at 20℃; Inert atmosphere; Stage #2: With acetic acid In methanol for 0.15h;	100%
With pyrrolidine In methanol at -10 - 20℃; for 1h; Inert atmosphere;	100%
With methylamine for 4.5h;	92%

4-hydroxy-benzaldehyde (123-08-0) + acetone (67-64-1) → (1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one (3654-49-7)

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 264h;	100%
With hydrogenchloride; acetic acid at 25 - 30℃; for 2h; Heating;	95%
With hydrogenchloride In acetic acid at 25 - 30℃; for 2h;	95%

4-methoxy-benzaldehyde (123-11-5) + acetone (67-64-1) → 4-(p-methoxyphenyl)-3-butene-2-one (943-88-4)

Conditions	Yield
With sodium hydroxide In water at 120℃; under 6750.68 Torr; Aldol condensation; Continuous flow;	100%
With 1-n-butyl-3-methylimidazolim bromide; bovine serum albumin at 60℃; for 6h; Aldol Condensation; Green chemistry; Enzymatic reaction;	98%
With sodium hydroxide for 72h; Ambient temperature;	97%

pivalaldehyde (630-19-3) + acetone (67-64-1) → 4-hydroxy-2,2-dimethyl-6-heptanone (101713-95-5)

Conditions	Yield
With sodium hydroxide at 20℃;	100%
Stage #1: acetone With sodium hydroxide In water at 20℃; Microfluidic conditions; Stage #2: pivalaldehyde; acetone In water at 20℃; Microfluidic conditions;	100%
With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 0.583333h;	47%

acetic acid hydrazide (1068-57-1) + acetone (67-64-1) → acetic acid isopropylidenehydrazide (3742-63-0)

Conditions	Yield
In cyclohexane at 55℃; for 16h;	100%
In hexane Reflux;	93%
In hexane for 4h; Heating;	91%

β-naphthaldehyde (66-99-9) + acetone (67-64-1) → 4-(2-naphtalenyl)-3-buten-2-one (75032-63-2)

Conditions	Yield
With potassium hydroxide In methanol; water at 20℃; for 0.5h;	100%
With boehmite at 55℃; for 24h; Aldol Condensation; Green chemistry;	55%
With sodium hydroxide

2,5-dimethoxybenzaldehyde (93-02-7) + acetone (67-64-1) → trans-1-(2,5-dimethoxyphenyl)-2-buten-3-one (118709-30-1)

Conditions	Yield
With sodium hydroxide at 23℃; for 6.5h;	100%
Stage #1: 2,5-dimethoxybenzaldehyde; acetone With L-proline In dimethyl sulfoxide at 20℃; for 48h; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide for 3h;	62.5%
With sodium hydroxide at 20℃; for 0.5h;	53%

phenylacetylene (536-74-3) + acetone (67-64-1) → 2-Methyl-4-phenyl-3-butyn-2-ol (1719-19-3)

Conditions	Yield
phosphazene base-P4-tert-butyl In hexane; dimethyl sulfoxide at 120℃; for 24h;	100%
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: acetone In tetrahydrofuran; hexane at -78 - 20℃;	100%
With Nd(3+)*8Na(1+)*10C4H9O(1-)*HO(1-) In dimethyl sulfoxide at 30℃; for 24h; Catalytic behavior; Concentration; Solvent; Reagent/catalyst; Inert atmosphere;	100%

aniline (62-53-3) + acetone (67-64-1) → N-(propan-2-ylidene)aniline (1124-52-3)

Conditions	Yield
With cis-(Cl,Cl)-[Re(p-NC6H4CH3)Cl2(py-2-COO)(PPh3)] at 70℃; for 24h; Inert atmosphere;	100%
With microporous zeolite at 230℃; for 24h; Sealed tube; Autoclave;	97%
sodium hydrogen sulfate; silica gel at 50 - 52℃; for 0.0333333h; microwave irradiation;	75%

2-amino-benzenethiol (137-07-5) + acetone (67-64-1) → 2,2-dimethyl-2,3-dihydro-benzothiazole (25111-89-1)

Conditions	Yield
at 0℃; for 2h; gas/solid reaction;	100%
Stage #1: 2-amino-benzenethiol; acetone In neat (no solvent) at 50℃; for 1h; Green chemistry; Stage #2: With o-benzenedisulfonimide In neat (no solvent) at 50℃; for 48h; Green chemistry;	87%
With aluminum oxide at 20℃; for 0.5h;	84%

4-dimethylamino-benzaldehyde (100-10-7) + acetone (67-64-1) → 4-p-dimethylaminophenyl-3-buten-2-one (5432-53-1)

Conditions	Yield
With sodium hydroxide for 72h; Ambient temperature;	100%
With water; potassium hydroxide at 20℃; for 0.2h;	82%
With sodium hydroxide In water at 0 - 20℃; Aldol condensation;	67.73%

1.3-propanedithiol (109-80-8) + acetone (67-64-1) → 2,2-dimethyl-1,3-dithiane (6007-22-3)

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane at 25℃;	100%
With titanium tetrachloride	79%
acid	78%

propylene glycol (57-55-6) + acetone (67-64-1) → 2,2,4-trimethyl-1,3-dioxolane (1193-11-9, 116944-25-3)

Conditions	Yield
With cyclohexane at 105℃; for 1h; Dean-Stark;	100%
With Amberlyst 36 at 50℃; for 2h;	75%
With 4 A molecular sieve; Amberlyst A 15 In tetrahydrofuran for 24h; Ambient temperature;	35%

3,4-dimethylbenzaldehyde (5973-71-7) + acetone (67-64-1) → (E)-4-(3,4-dimethylphenyl)but-3-en-2-one (97241-86-6)

Conditions	Yield
With sodium hydroxide In water at 0 - 25℃; for 6h;	100%
With sodium hydroxide
With sodium hydroxide In water at 25℃; for 12h;

2-nitrobenzenesulfonyl hydrazide (5906-99-0) + acetone (67-64-1) → N-isopropylidene-N’-2-nitrobenzenesulfonyl hydrazine (6655-27-2)

Conditions	Yield
at 0℃; for 1h;	100%
at 24℃; for 0.166667h; Inert atmosphere;	95%
at 0 - 23℃;	89%

acetone (67-64-1) + glycerol (56-81-5) → (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8)

Conditions	Yield
With sulfuric acid at 40℃; Reagent/catalyst;	100%
With toluene-4-sulfonic acid In hexane at 70℃; for 12h; Dean-Stark; Molecular sieve; Inert atmosphere;	100%
Acidic conditions;	100%

acetone (67-64-1) + 3,4-dichlorobenzaldehyde (6287-38-3) → (1E,4E)-1,5-bis(3,4-dichlorophenyl)penta-1,4-dien-3-one (30983-80-3)

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 1h;	100%
With sodium hydroxide In ethanol; water at 20℃; Aldol Addition;	70%
With sodium hydroxide
With sodium hydroxide In ethanol

acetone (67-64-1) + uridine (58-96-8) → 2',3'-O-isopropylideneuridine (362-43-6)

Conditions	Yield
With sulfuric acid at 20℃; for 1h;	100%
Stage #1: acetone; uridine With sulfuric acid at 20℃; for 1h; Stage #2: With triethylamine In acetone Product distribution / selectivity;	100%
With sulfuric acid at 20℃; for 1h;	100%

acetone (67-64-1) + ethylhydrazine carboxylate (4114-31-2) → N'-isopropylidenehydrazinecarboxylic acid ethyl ester (6637-60-1)

Conditions	Yield
	100%
With magnesium sulfate Reflux;	100%
for 2h; Heating;	98%

acetone (67-64-1) → (2-2H)propan-2-(2H)ol (19214-95-0)

Conditions	Yield
With lithium aluminium deuteride In diethylene glycol dimethyl ether at 0℃; for 1h; Inert atmosphere;	100%
With pyrographite; platinum; deuterium at 25℃; under 1520 Torr; an mit Eisensalz;
With lithium aluminium deuteride

acetone (67-64-1) → acetylmethanenitrolic acid (6868-83-3)

Conditions	Yield
With dinitrogen tetraoxide In tetrachloromethane 1.) 0 deg C, 20 min, 2.) 20 deg C, 40 min;	100%
With nitric acid

acetone (67-64-1) → isopropyl alcohol (67-63-0)

Conditions	Yield
With hydrogen; mer-Os(PPh3)3HBr(CO) In toluene at 150℃; under 51680 Torr; for 3h;	100%
With hydrogen; sodium methylate; chromium(0) hexacarbonyl In methanol at 120℃; under 75006 Torr; for 3h;	100%
With hydrogen; Ru((R,R)-cyP2N2)HCl In benzene-d6 at 20℃; under 2280.15 Torr; for 12h; Product distribution / selectivity; Alkaline conditions; Cooling with liquid nitrogen;	100%

acetone (67-64-1) + methyl α-D-lyxopyranoside (18449-76-8) → methyl 2,3-O-isopropylidene-α-D-lyxopyranoside (60562-98-3)

Conditions	Yield
With 4 A molecular sieve; amberlyst-15 (H form) at 23℃; for 4h;	100%
With sulfuric acid; copper(II) sulfate for 24h; Ambient temperature;	81%
With sulfuric acid
With phosphorus pentoxide

acetone (67-64-1) + adenosine (58-61-7) → 2',3'-isopropylidene adenosine (362-75-4)

Conditions	Yield
With toluene-4-sulfonic acid; orthoformic acid triethyl ester at 20℃;	100%
With p-toluenesulfonic acid monohydrate for 3h; Inert atmosphere;	100%
With toluene-4-sulfonic acid at 20℃; for 1h; Inert atmosphere;	99%

benzaldehyde (100-52-7) + acetone (67-64-1) → 1-hydroxy-1-phenyl-3-butanone (5381-93-1, 86734-67-0, 86734-69-2, 127707-68-0)

Conditions	Yield
With sodium hydroxide at 20℃;	100%
Stage #1: acetone With sodium hydroxide In water at 20℃; Microfluidic conditions; Stage #2: benzaldehyde; acetone In water at 20℃; Microfluidic conditions;	100%
With pyrrolidine; 4-nitro-phenol at 20℃; for 2.5h;	99.4%

Upstream product

• 64742-89-8 PETROLEUM ETHER 
• 8030-97-5 PYROLIGNEOUS ACID 
• 13530-65-9 ZINC CHROMATE 
• 6388-47-2 2-Amino-3-chlorobenzoic acid 
• 25321-09-9 DIISOPROPYLBENZENE 
• 98-82-8 CUMENE 
• 80-15-9 Cumyl hydroperoxide 
• 62-54-4 Calcium acetate 

Downstream Products

• 81152-53-6 2-(4-(CHLOROMETHYL)THIAZOL-2-YL)GUANIDINE 
• 23806-24-8 3-Methyl-2-thiophenecarboxylic acid 
• 33603-63-3 4-(2-THIENYL)BUT-3-EN-2-ONE 
• 67869-90-3 3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE-7-CARBALDEHYDE 
• 4202-14-6 Dimethyl acetylmethylphosphonate 
• 115-19-5 3-Methyl butynol 
• 15103-48-7 PYRIDINE-2-SULFONIC ACID 
• 75-47-8 Iodoform 
• 31005-02-4 7-ETHOXYCOUMARIN 
• 879-72-1 3-DIMETHYLAMINOPROPIOPHENONE HYDROCHLORIDE 
• 2627-95-4 Divinyltetramethyldisiloxane 
• 132-60-5 CINCHOPHEN 
• 39831-55-5 Amikacin disulfate salt 
• 3160-35-8 4-Hydroxybenzylideneacetone 
• 2131-62-6 4-CARBOXYPHENYL ISOTHIOCYANATE 
• 51-43-4 L(-)-Epinephrine 
• 73728-40-2 2-(MORPHOLINE-4-CARBONYL)-BENZOIC ACID 
• 78-11-5 Pentaerythritol tetranitrate 
• 53595-68-9 2,5-Dichlorothiophene-3-sulfonamide 
• 22612-89-1 1,1,3,3-TETRABROMOACETONE 
• 111-56-8 2-BROMODODECANOIC ACID 
• 61439-59-6 2-(4-BENZYLOXYPHENYL)ETHANOL 
• 91-53-2 Ethoxyquin 
• 149022-22-0 Amikacin sulfate salt 
• 6267-02-3 9,9-dimethylcarbazine 
• 5469-70-5 Pyridazin-3-amine 
• 586-06-1 Orciprenaline 
• 1076-74-0 5-METHOXY-2-METHYLINDOLE 
• 144-48-9 2-Iodoacetamide 
• 15591-42-1 3-(-Hydroxyphenethyl)-2-imino thiazolidine 
• 2421-28-5 3,3',4,4'-Benzophenonetetracarboxylic dianhydride 
• 531-59-9 7-Methoxycoumarin 
• 583-11-9 1-Phenylethanone phenylhydrazone 
• 5891-53-2 H-GLU-LYS-OH 
• 94-41-7 CHALCONE 

Recommend Products

• 187737-37-7  propene 
• 74-84-0  ethane 
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• 2916-31-6  2,2-dimethyl-1,3-dioxolane 
• 109-63-7  trifluoroborane diethyl ether 
• 34557-54-5  methane 
• 74-85-1  ethene 
• 151-56-4  ethyleneimine 
• 110-05-4  di-tert-butyl peroxide 
• 4685-15-8  N,N'-bis-(aziridine-1-carbonyl)-pentanediyldiamine 
• 4538-42-5  1,5-diisocyanatopentane 
• 19351-18-9  2,2-dimethyl-1,3-thiazolidine