229184-00-3

Basic information

• Product Name: 2-(3-bromopyridin-4-yl)ethanol
• Synonyms: 2-(3-bromopyridin-4-yl)ethanol
• CAS NO: 229184-00-3
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.04852
• Mol File: 229184-00-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-bromopyridin-4-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromopyridin-4-yl)ethanol(229184-00-3)
• EPA Substance Registry System: 2-(3-bromopyridin-4-yl)ethanol(229184-00-3)

Safety Data

• Hazardous Substances Data: 229184-00-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-(3-bromopyridin-4-yl)ethanol is used as a building block for the synthesis of various organic compounds. Its unique structure, which includes a bromine atom and an ethanol group, allows for a range of chemical reactions that can be utilized in the creation of new molecules.
Used in Pharmaceutical Industry:
2-(3-bromopyridin-4-yl)ethanol is used as an intermediate in the development of pharmaceutical drugs. Its reactivity and structural features make it a valuable component in the synthesis of potential drug candidates, particularly in the areas of central nervous system agents, cardiovascular drugs, and other therapeutic applications.
Used in Research and Development:
2-(3-bromopyridin-4-yl)ethanol is used as a research compound for studying the properties and potential applications of pyridine derivatives. Its unique structure provides opportunities for exploring new chemical reactions and understanding the behavior of similar compounds in various chemical environments.

Upstream product

• 1430235-67-8 C₁₉H₁₇BrFNSi 
• 1430235-04-3 1-(4-pyridyl)-2-(diphenylsilyl)ethane 
• 1430235-05-4 C₁₉H₁₇NSi 
• 100-43-6 4-vinylpyridine 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 162615-12-5 methyl 2-(3-bromopyridin-4-yl)acetate 

Relevant articles and documents

Synthetic approaches to tetrahydro-2,7- and -1,6-naphthyridines

Three new tetrahydronaphthyridines were prepared starting from readily available 3-bromo-picolines. The key step of the proposed strategy consists of reduction of the imine prepared by intramolecular reaction of the acyl and amine groups. The amine group was introduced via deprotonation of the methyl group in bromopicoline, its reaction with dimethylcarbonate, reduction to the corresponding alcohol and Mitsunobu reaction with phthalamide. The acyl group was placed at the bromine position via the Stille cross-coupling reaction of tributyl(1-ethoxyvinyl)stannane followed by hydrolysis. The proposed chemical sequence allowed the multigram preparation of tetrahydro-2,7- and 1,6-naphthyridines.

ISOQUINOLINES AS INHIBITORS OF HPK1

Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Fused heteroaromatic dihydrosiloles: Synthesis and double-fold modification

An efficient method for the synthesis of fused heteroaromatic dihydrosiloles via Ni-catalyzed hydrosilylation/intramolecular Ir-catalyzed dehydrogenative coupling of the Si-H bond with the heteroaromatic C-H bond has been developed. The method is efficient for both electron-deficient and -rich heterocycles. It exhibits high functional group tolerance and good regioselectivity. Fused heteroaromatic dihydrosiloles can be smoothly halogenated and then oxidized or arylated. Application of these transformations allows obtaining highly functionalized heteroaromatic structures. A gram-scale synthesis of dihydropyridinosilole has also been accomplished using reduced amounts of Ni- and Ir-catalysts.