- Process for the preparation of 2-aminomethylpiperidine
-
The invention relates to a process for the preparation of aminomethylpyridines of the general formula (I) by hydrogenation of cyanopyridines of the general formula (II) with hydrogen under increased pressure optionally in the presence of a catalyst containing Ni, Fe or Co and optionally in the presence of ammonia.
- -
-
Page/Page column 1
(2008/12/07)
-
- Synthesis and antitumor activities of platinum complexes of unsymmetrical alicyclic diamines as carrier ligands
-
The synthesis and biological activities of the platinum complexes of 2-aminomethylaziridine, 2-aminomethylazetidine, 2-aminomethylpyrrolidine, and 2-aminomethylpiperidine as carrier ligands are described. The platinum complexes of 2-aminomethylazetidine and 2-aminomethylpyrrolidine are significantly effective against murine tumors. In particular, 2-aminomethylazetidine (1,1-cyclobutanedi-carboxyplato)platinum II (13) and 2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)platinum II (16) exhibited potent antitumor activity and were soluble in water, and their antitumor activities against Colon 26 carcinoma (sc-ip system) were superior to CBDCA and comparable to CDDP.
- Morikawa,Honda,Endoh,Matsumoto,Akamatsu,Mitsui,Koizumi
-
p. 750 - 753
(2007/10/02)
-
- Preparation of esters of phosphorus acids
-
Esters of phosphorus acids are prepared by an improved process whereby aromatic alcohols and phosphorus halides are reacted at specified temperatures in the presence of amine catalysts thereby providing high yields of substantially pure esters and allowing preparation of selected halogen-containing mono- and di-esters of phosphorus acids wherein halogen is directly bonded to phosphorus having substantially no side reactant contamination. The phosphorus esters are useful as intermediates in the preparation of plasticizers, oil additives and functional fluids.
- -
-
-