PYRAZINE DERIVATIVE AND APPLICATION THEREOF IN INHIBITING SHP2
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(2022/01/23)
Flow hydrodediazoniation of aromatic heterocycles
Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimised to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines, to be deaminated in good yield using a purely organic-soluble system.
R?der, Liesa,Nicholls, Alexander J.,Baxendale, Ian R.
(2019/06/05)
Palladium-Catalyzed Domino Allenamide Carbopalladation/Direct C-H Allylation of Heteroarenes: Synthesis of Primprinine and Papaverine Analogues
Palladium-catalyzed intramolecular carbopalladation onto allenamides completed by direct C-H allylation of heterocycles is studied. The domino construction/heteroarylation of isoquinolone process is first achieved. A general three-step one-pot strategy, i
This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
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Page/Page column 47
(2009/07/17)
BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS
The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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Page/Page column 33-34
(2008/06/13)
A practical synthesis of 1,3-oxazole
A short synthesis of oxazole (1,3-oxazole, 1) is described.
Shafer, Cynthia M.,Molinski, Tadeusz F.
p. 1167 - 1170
(2007/10/03)
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