Quinolines as potent 5-lipoxygenase inhibitors: Synthesis and biological profile of L-746,530
Leukotriene biosynthesis inhibitors have potential as new therapeutic agents for asthma and inflammatory diseases. A series of novel substituted 2- cyanoquinolines have been synthesized and the structure activity relationships were evaluated with respect
Dube, Daniel,Blouin, Marc,Brideau, Christine,Chan, Chi-Chung,Desmarais, Sylvie,Ethier, Diane,Falgueyret, Jean-Pierre,Friesen, Richard W.,Girard, Mario,Girard, Yves,Guay, Jocelyne,Riendeau, Denis,Tagari, Philip,Young, Robert N.