230638-19-4Relevant articles and documents
Synthesis and reactions of 4-hydroxy-2(1H)-pyridones with thienyl and pyridyl substituents in position 6 starting with azomethines and malonates
Schnell, Barbara
, p. 541 - 548 (2007/10/03)
The reaction of 4 with substituted diethyl malonates 5a, or 'magic malonates' (bis-2,4,6-trichlorophenylmalonates 5b) leads to 4-hydroxy-2(1H)- pyridones 6. The azomethines 4 are prepared via the Strecker compounds 3 starting with methyl ketones 1, anilines, and potassium cyanide. Chlorination of pyridones 6 with sulfuryl chloride leads to compounds 7 while nitration gives 9.