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1-(3-Aminopropyl)pyrrolidine is an organic compound that serves as a crucial intermediate in various chemical syntheses. It is a clear, slightly yellow liquid with unique chemical properties that make it valuable in the creation of other chemicals and compounds.

23159-07-1

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23159-07-1 Usage

Uses

1. Used in Organic Synthesis:
1-(3-Aminopropyl)pyrrolidine is used as a key intermediate for the synthesis of various organic compounds due to its reactive functional groups.
2. Used in Pharmaceutical Industry:
1-(3-Aminopropyl)pyrrolidine is used as an important raw material in the pharmaceutical industry for the development of new drugs and therapeutic agents.
3. Used in Agrochemicals:
In the agrochemical industry, 1-(3-Aminopropyl)pyrrolidine is utilized as a vital component in the production of various agrochemical products, contributing to its effectiveness and performance.
4. Used in Dyestuff Industry:
1-(3-Aminopropyl)pyrrolidine is employed as a raw material in the dyestuff industry, where it is used to create a range of dyes with specific properties and applications.
5. Used in Chemical Production:
1-(3-Aminopropyl)pyrrolidine is used as a starting material to produce other chemicals, showcasing its versatility and importance in the chemical industry.
6. Used in the Synthesis of 5-methyl-8-(3-pyrrolidin-1-yl-propyl)-7,8-dihydro-6H-1,3,4,8,8b-pentaaza-as-indacene:
1-(3-Aminopropyl)pyrrolidine is used as a reactant in the synthesis of this specific compound, which has potential applications in various fields.
7. Used in the Synthesis of 2,4-diphenyl-cyclobutane-1,3-dicarboxylic acid bis-[(3-pyrrolidin-1-yl-propyl)-amide]:
1-(3-Aminopropyl)pyrrolidine is also used in the production of 1-(3-Aminopropyl)pyrrolidine, highlighting its role in creating complex chemical structures with specific properties and uses.

Check Digit Verification of cas no

The CAS Registry Mumber 23159-07-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,1,5 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 23159-07:
(7*2)+(6*3)+(5*1)+(4*5)+(3*9)+(2*0)+(1*7)=91
91 % 10 = 1
So 23159-07-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H16N2/c8-4-3-7-9-5-1-2-6-9/h1-8H2/p+2

23159-07-1 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (L04739)  1-(3-Aminopropyl)pyrrolidine, 97%   

  • 23159-07-1

  • 5g

  • 608.0CNY

  • Detail
  • Alfa Aesar

  • (L04739)  1-(3-Aminopropyl)pyrrolidine, 97%   

  • 23159-07-1

  • 25g

  • 2310.0CNY

  • Detail

23159-07-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-pyrrolidin-1-ylpropan-1-amine

1.2 Other means of identification

Product number -
Other names 1-(3-Aminopropyl)-pyrrolidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23159-07-1 SDS

23159-07-1Relevant articles and documents

Studies of Pendant-arm Macrocyclic Ligands. Part 5. Synthesis of Two Pyridine-containing Penta-aza Macrocycles with Single Pyrrolidinyl Pendant Arms and Characterisation of their Nickel(II) and Copper(II) Complexes. Crystal Structure of Perchlorato-3,7,...

Alcock, Nathaniel W.,Balakrishnan, Karappulli P.,Moore, Peter,Omar, Hadi A. A.

, p. 545 - 550 (1987)

Two new pyridine-containing penta-aza macrocyclic ligands, 7-- and 7--3,7,11,17-tetra-azabicycloheptadeca-1(17),13,15-triene (L1 and L2 respectively) have been prepared, and their nickel(II) and copper(II) complexes of formulae 1)(OClO3)> and 3 (M = Ni or Cu, L = L1 or L2) have been isolated and characterised.In the octahedral complex 1)(OClO3)> the presence of a co-ordinated perchlorate group has been established by X-ray crystallography, and the macrocyclic ligand found to co-ordinate close to the corners of a square pyramid with the pendant pyrrolidinyl group at the apical position.

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

Tazarki, Helmi,Zeinyeh, Wael,Esvan, Yannick J.,Knapp, Stefan,Chatterjee, Deep,Schr?der, Martin,Joerger, Andreas C.,Khiari, Jameleddine,Josselin, Béatrice,Baratte, Blandine,Bach, Stéphane,Ruchaud, Sandrine,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale

, p. 304 - 317 (2019/02/07)

Cdc2-like kinase 1 (CLK1) and dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) are involved in the regulation of alternative pre-mRNA splicing. Dysregulation of this process has been linked to cancer progression and neurodegenerative diseases, making CLK1 and DYRK1A important therapeutic targets. Here we describe the synthesis of new pyrido[3,4-g]quinazoline derivatives and the evaluation of the inhibitory potencies of these compounds toward CDK5, CK1, GSK3, CLK1 and DYRK1A. Introduction of aminoalkylamino groups at the 2-position resulted in several compounds with low nanomolar affinity and selective inhibition of CLK1 and/or DYRK1A. Their evaluation on several immortalized or cancerous cell lines showed varying degree of cell viability reduction. Co-crystal structures of CLK1 with two of the most potent compounds revealed two alternative binding modes of the pyrido[3,4-g]quinazoline scaffold that can be exploited for future inhibitor design.

NITROGEN-CONTAINING COMPOUNDS SUITABLE FOR USE IN THE PRODUCTION OF POLYURETHANES

-

Paragraph 0275; 0276, (2018/07/31)

The present invention provides for the use of nitrogen compounds of formula (I) and/or of corresponding quaternized and/or protonated compounds for production of polyurethanes, compositions containing these compounds and polyurethane systems, especially polyurethane foams, which have been obtained using the compounds.

Identification and Structure–Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1

Robaa, Dina,Wagner, Tobias,Luise, Chiara,Carlino, Luca,McMillan, Joel,Flaig, Ralf,Schüle, Roland,Jung, Manfred,Sippl, Wolfgang

supporting information, p. 2327 - 2338 (2016/10/24)

The methyllysine reader protein Spindlin1 has been implicated in the tumorigenesis of several types of cancer and may be an attractive novel therapeutic target. Small-molecule inhibitors of Spindlin1 should be valuable as chemical probes as well as potential new therapeutics. We applied an iterative virtual screening campaign, encompassing structure- and ligand-based approaches, to identify potential Spindlin1 inhibitors from databases of commercially available compounds. Our in silico studies coupled with in vitro testing were successful in identifying novel Spindlin1 inhibitors. Several 4-aminoquinazoline and quinazolinethione derivatives were among the active hit compounds, which indicated that these scaffolds represent promising lead structures for the development of Spindlin1 inhibitors. Subsequent lead optimization studies were hence carried out, and numerous derivatives of both lead scaffolds were synthesized. This resulted in the discovery of novel inhibitors of Spindlin1 and helped explore the structure–activity relationships of these inhibitor series.

Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents

Luo, Wen,Wang, Ting,Hong, Chen,Yang, Ya-Chen,Chen, Ying,Cen, Juan,Xie, Song-Qiang,Wang, Chao-Jie

supporting information, p. 17 - 26 (2016/07/06)

A new series of 4-dimethylamine flavonoid derivatives were designed and synthesized as potential multifunctional anti-Alzheimer agents. The inhibition of cholinesterase activity, self-induced β-amyloid (Aβ) aggregation, and antioxidant activity by these derivatives was investigated. Most of the compounds exhibited potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity. A Lineweaver-Burk plot and molecular modeling study showed that these compounds targeted both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. The derivatives showed potent self-induced Aβ aggregation inhibition and peroxyl radical absorbance activity. Moreover, compound 6d significantly protected PC12 neurons against H2O2-induced cell death at low concentrations. Thus, these compounds could become multifunctional agents for further development for the treatment of AD.

Synthesis and antitumor activity of 5-bromo-7-azaindolin-2-one derivatives containing a 2,4-dimethyl-1H-pyrrole-3-carboxamide moiety

Zhang, Jun,Shen, Weiyi,Li, Xiaoning,Chai, Yun,Li, Senjun,Lv, Kai,Guo, Huiyuan,Liu, Mingliang

, (2016/12/30)

We report herein the design and synthesis of a series of novel 5-bromo-7-azaindolin-2-one derivatives containing a 2,4-dimethyl-1H-pyrrole-3-carboxamide moiety. These newly synthesized derivatives were evaluated for in vitro activity against selected cancer cell lines by MTT assay. Results revealed that some compounds exhibit broad-spectrum antitumor potency, and the most active compound 23p (IC50: 2.357-3.012 μM) was found more potent than Sunitinib (IC50: 31.594-49.036 μM) against HepG2, A549 and Skov-3, respectively.

Novel n(phenylsulphonyl)glycine derivatives and their therapeutic use

-

, (2008/06/13)

The present invention relates to novel N-(phenylsulphonyl)glycyl-glycine compounds, which are defined by formula I and the description, as well as their method of preparation and their use in therapeutics

A new class of histamine H3-receptor antagonists: Synthesis and structure - Activity relationships of 7,8,9,10-Tetrahydro-6H-cyclohepta[b]quinolines

Turner, Sean C.,Esbenshade, Timothy A.,Bennani, Youssef L.,Hancock, Arthur A.

, p. 2131 - 2135 (2007/10/03)

The synthesis and biological evaluation of novel cycloheptaquinoline antagonists of the human H3 receptor are described. Two series of compounds, bearing either an amino substituent or an alkyne linker at the 11-position, were investigated. Modifications of the amino substituents, optimization of chain length and the effect of conformational restraints are described. Several compounds with high affinity and selectivity for the H3 receptor were discovered.

2-aminobenzoxazole derivatives and combinatorial libraries thereof

-

, (2008/06/13)

The present invention relates to novel 2-aminobenzoxazole derivative compounds of the following formula: wherein R1 to R4 and Z have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminobenzoxazole derivative compounds.

N-SUBSTITUTED-N'-SUBSTITUTED UREA DERIVATIVE AND USE THEREOF AS TNF-γ(a) PRODUCTION INHIBITOR

-

Page 8, (2008/06/13)

N-Substituted-N'-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF- α production inhibitory activity.

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