232617-15-1

Basic information

• Product Name: RibCys
• Synonyms: (1R)-1-[(4R)-4-Carboxythiazolidine-2-yl]-D-erythro-tetritol;(4R)-2-[(1R,2R,3R)-1,2,3,4-Tetrahydroxybutyl]thiazolidine-4-carboxylic acid;(4R)-2-[(1R,2R,3R)-1,2,3,4-Tetrahydroxybutyl]thiazolidine-4α-carboxylic acid;RibCys;D-Ribose-L-cysteine (Mixture of DiastereoMers)
• CAS NO: 232617-15-1
• Molecular Formula: C₈H₁₅NO₆S
• Molecular Weight: 225.2627
• Mol File: 232617-15-1.mol

Chemical Properties

• Boiling Point: 654.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.624±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Methanol (Slightly, Heated), Water (Slightly)
• PKA: 1.97±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: RibCys(CAS DataBase Reference)
• NIST Chemistry Reference: RibCys(232617-15-1)
• EPA Substance Registry System: RibCys(232617-15-1)

Safety Data

• Hazardous Substances Data: 232617-15-1(Hazardous Substances Data)

Usage

Uses

Used in Oncology:
RibCys is used as an anti-cancer agent for the inhibition of astrocytoma cell proliferation. Astrocytoma is a type of brain cancer, and RibCys has demonstrated potential therapeutic advantages in this application, making it a valuable tool in the fight against this aggressive form of cancer.
Used in Hepatic and Renal Protection:
RibCys is used as a protective agent against acetaminophen-induced hepatic (liver) and renal (kidney) toxicity. Acetaminophen is a common pain reliever and fever reducer, but in high doses, it can cause severe damage to the liver and kidneys. RibCys has been shown to help protect these vital organs from the harmful effects of acetaminophen overdose, offering a potential therapeutic solution for those at risk of organ damage due to the use of this medication.

Upstream product

• 50-69-1 D-ribose 
• 52-89-1 l-cysteine hydrochloride 
• 52-90-4 L-Cysteine 
• 110-86-1 pyridine 
• 7732-18-5 water 
• 127-08-2 potassium acetate 

Downstream Products

• 30080-15-0 (2Ξ,4R)-3-acetyl-2-(D_r-1c_F,2c_F,3r_F,4-tetraacetoxy-but-cat_F-yl)-thiazolidine-4-carboxylic acid 

Relevant articles and documents

Methods Of Preparing Thiazolidines

The present invention provides methods of preparing thiazolidines, and in particular methods of preparing ribose-cysteine.

Method to enhance delivery of glutathione and ATP levels in cells

A therapeutic method is provided comprising treating a mammal subject to hypoxia with an amount of 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (RibCys) or a pharmaceutically acceptable salt thereof effective to both maintain, restore or increase both the ATP levels and the glutathione (GSH) levels in said tissue.

Proton and Zinc(II) Complexes of 2-(Polyhydroxyalkyl)thiazolidine-4-carboxylic acid Derivatives

The protonation and zinc-ion co-ordination equilibria of 2-(polyhydroxyalkyl)thiazolidine-4-carboxylic acid derivatives have been studied by potentiometric titration in the range pH 1.5-8.In most cases the formation of complexes with a metal-to-ligand ratio of 1:2 was demonstrated, but at above pH 6 mixed-ligand complexes involving hydroxide-ion co-ordination were also observed.The protonation and complex-formation constants were shown to depend on the structure of the polyhydroxy chains.In the case of the protonation constants this is due to the rearrangement of the intramolecular hydrogen-bonding network, while the complex-formation constants depend on the conformation of the OH groups on the first carbon atoms of the polyol chains.