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52-90-4 Usage

description

L-Cysteine is one of the 20 natural amino acids and, besides methionine,the only one which contains sulfur. It is a thiol-containing non-essential amino acid that is oxidized to form Cystine. It is a non-essential sulfur-containing amino acid in humans, related to cystine, Cysteine is important for protein synthesis, detoxification, and diverse metabolic functions. Found in beta-keratin, the main protein in nails, skin, and hair, Cysteine is important in collagen production, as well as skin elasticity and texture. Also required in the manufacture of amino acid taurine, Cysteine is a component of the antioxidant glutathione, and plays a role in the metabolism of essential biochemicals such as coenzyme A, heparin, and biotin. L-cysteine hydrochloride is used in the baking industry as dough conditioner. Specially, it breaks the disulfide bonds of gluten, which lowers the viscosity of the dough. It is then easier to work with and increases the elasticity of the dough, helping it to rise during baking. L-cysteine is available through many dietary sources, primarily animal protein. Eggs and dairy products also contain significant levels of l-cysteine. Vegetable sources of l-cysteine include broccoli, Brussels sprouts, garlic, granola, sprouted lentils, oats, onions and peppers. The commercial extraction of l-cysteine typically uses human hair, due to its high concentration of this amino acid. Other commercial sources include hog hair and poultry feathers. L-cysteine may also be synthesized in a process that involves fermentation by a variety of E. coli.

Sheep

Cysteine is required by sheep in order to produce wool: It is an essential amino acid that must be taken in as food from grass. As a consequence, during drought conditions, sheep stop producing wool; however, transgenic sheep that can make their own cysteine have been developed.

Uses

cysteine is an essential amino acid obtained by fermentation. Cysteine is a component of the skin’s natural moisturizing factor and can help normalize oil gland secretion because of its sulfur content. It is also said to promote wound healing. In addition, studies indicate that cysteine helps increase levels of glutathione (an anti-oxidant) in the body. It is considered beneficial in treating oily skin.

Chemical Properties

A sulfur-containing amino acid, metabolically related to methionine. Methionine is the source of sulfur atom in the synthesis of cysteine in the body. Chemically, L-cysteine is L-2-amino-mercaptopropionic acid. Cysteine has a sulfureous aroma. It is a nutrient and is used in dietary supplements.

Occurrence

Dietary sources Although classified as a non-essential amino acid, in rare cases, cysteine may be essential for infants, the elderly, and individuals with certain metabolic disease or who suffer from malabsorption syndromes. Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Cysteine is catabolized in the gastrointestinal tract and blood plasma. In contrast, cystine travels safely through the GI tract and blood plasma and is promptly reduced to the two cysteine molecules upon cell entry. Industrial sources The majority of L - cysteine is obtained industrially by hydrolysis of poultry feathers or human hair. Synthetically produced L-cysteine, compliant with Jewish Kosher and Muslim Halal rules, is also available, albeit at a higher price. The synthetic route involves fermentation utilizing a mutant of E. coli. Biosynthesis In animals, biosynthesis begins with the amino acid serine. The sulfur is derived from methionine, which is converted to homocysteine through the intermediate S- adenosylmethionine. Cystathionine betasynthase then combines homocysteine and serine to form the asymmetrical thioether cystathionine. The enzyme cystathionine gamma-lyase converts the cystathionine into cysteine and alphaketobutyrate.

Chemical properties

L-cysteine (chemical name, 2-amino-3-mercaptopropionic acid or mercapto alanine) is a mercapto-containing aliphatic neutral amino acid. It is colorless crystal with isoelectric point of 5.07, PK1 = 1.71, pK2 = 8.33, and pK3 = 10.78. It is Soluble in water, ethanol, acetic acid and ammonia, while not soluble in benzene, carbon tetrachloride, ethyl acetate, carbon disulfide, ether and acetone. L-cysteine is an essential component of the protein and can be synthesized from serine or methionine in animals. L-cysteine comes to decompose while heated to 240 ° C, and can be quickly oxidized by air to form cystine in neutral or slightly alkaline solution. The acid solution of L-cysteine can be stored for several days, and stored better under the protection of nitrogen. The aqueous solution of levorotatory L-cysteine changes into dark blue after adding ferric chloride. It can be produced by the degradation of cystine, and also can be obtained by the hydrochloric acid hydrolysis, copper oxide treatment and then hydrogen sulfide decomposition of human hair and other silkworm. L-cysteine can be used for anti-radiation and the treatment of radiation sickness, as well as for hepatitis, liver poisoning, radiopharmaceutical poisoning, acrylonitrile and antimony poisoning and allergic diseases in medicine. It can also be applied for the biochemical and nutritional research. Pyruvate and mercaptoethanamine are its general catabolites. It is involved in the synthesis of glutathione, taurine and so on. The disulfide bridge in the polypeptide chain is also formed by dehydrogenation and condensation of two molecules of cysteine.

physiological effects

Cysteine can help the detoxification of the body. It is the best free radical scavenger combined with selenium and vitamin E. Cysteine is also the precursor of glutathione, which is capable of binding with poisonous substances for detoxication in the liver. It can protect the liver and brain from the damage of cigarettes, alcohol and drugs. Since cysteine is more soluble than cystine, it is easier for cysteine to be used by the body to treat various diseases. Vitamin B6 is required for in vivo cysteine synthesis. Cysteine can not be synthesized in the presence of chronic conditions, so people with chronic diseases need a higher dose of cysteine, for example, 3 times a day for 1 month. The patients with rheumatoid arthritis, vascular sclerosis or cancer need to supplement cysteine. Cysteine can also assists people to accelerate recovery after surgery and burns. It can form complexes with heavy metals, and enhance iron absorption. These two amino acids can also accelerate the use of fat and formation of muscle. Cysteine can clears mucus in the respiratory tract, so it can treat bronchitis, emphysema and tuberculosis. Cysteine (or acetyl-linked acetylcysteine) can be used to prevent the side effects in cancer chemotherapy or radiation therapy. It can also increase the level of glutathione in lung, kidney, liver and bone marrow, so it has anti-aging effects, for example, it can reduce the incidence of age spots. Cysteine can inactivates insulin. Therefore, patients with diabetes can not take cysteine. Genetic cystinuria can result in cystine stones, so people with genetic cystinuria can not take these two amino acids.

Uses

L-cysteine can be used as bread improver, nutritional supplements, antioxidants and color fixative. It can also be applied for curing acrylonitrile and aromatic acid poisoning, preventing radiation damage and treating bronchitis and phlegm. L-cysteine can absorb alcohol and convert it into acetaldehyde to alleviate a hangover. L-cysteine can be used for the treatment of eczema, urticaria, freckles and other skin diseases. And its series products are widely used in medicine, food and cosmetics industry L-cysteine can be used for biochemical research and as the antidote for hepatitis, liver poisoning, radiopharmaceutical poisoning, antimony poisoning, etc. L-cysteine is mainly used for medicine, cosmetics, biochemical research and so on. It can be used in the bread material to accelerate the formation of gluten and to promote fermenting and depanning, as well as to prevent aging. It can be used in natural fruit juices to prevent oxidation of vitamin C and to prevent fruit juice from becoming brown. The product has detoxification effect and can be used for curing acrylonitrile poisoning and aromatic acidosis. This product also has the role of preventing the human body from radiation damage. It can be used as bronchitis drugs, especially as phlegm drugs (mostly in the form of acetyl L-cysteine methyl ester salt). In cosmetics, it is mainly used as cosmetic water, perm solution, anti-sun cream and other skin care. L-cysteine can be used as the receptor agonists of NMDA glutamate.

Occurrence

Dietary sourcesAlthough classified as a non - essential amino acid, in rare cases, cysteine may be essential for infants, the elderly, and individuals with certain metabolic disease or who suffer from malabsorption syndromes. Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Cysteine is catabolized in the gastrointestinal tract and blood plasma . In contrast, cystine travels safely through the GI tract and blood plasma and is promptly reduced to the two cysteine molecules upon cell entry. Cysteine is found in most high-protein foods, including : Animal sources: pork, sausage meat, chicken, turkey, duck, luncheon meat, eggs, milk, whey protein, ricotta, cottage cheese, yogurt Plant sources: red peppers, garlic, onions, broccoli, brussels sprout, oats, granola, wheat germ, sprouted lentils. Like other amino acids, cysteine has an amphoteric character.Industrial sourcesThe majority of L-cysteine is obtained industrially by hydrolysis of poultry feathers or human hair. Synthetically produced L-cysteine, compliant with Jewish Kosher and Muslim Halal rules, is also available, albeit at a higher price . The synthetic route involves fermentation utilizing a mutant of E. coli. Degussa introduced a route from substituted thiazolines. Following this technology, L-cysteine is produced by the hydrolysis of racemic 2-amino-Δ22-thiazoline-4- carboxylic acid using Pseudomonas thiazolinophilum.BiosynthesisIn animals, biosynthesis begins with the amino acid serine. The sulfur is derived from methionine, which is converted to homocysteine through the intermediate S- adenosylmethionine. Cystathionine betasynthase then combines homocysteine and serine to form the asymmetrical thioether cystathionine. The enzyme cystathionine gamma-lyase converts the cystathionine into cysteine and alphaketobutyrate. In plants and bacteria, cysteine biosynthesis again starts from serine, which is converted to O-acetylserine by the enzyme serine transacetylase. The enzyme O-acetylserine (thiol)-lyase, using sulfide sources, converts this ester into cysteine, releasing acetate.

Uses

L-Cysteine is a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. L-Cysteine is commonly use d as a precursor in the food and pharmaceutical industries. L-Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours.

Uses

Cysteine is a nonessential amino acid that functions as a nutrient and dietary supplement. It is used in foods to prevent oxygen from destroying vitamin c and is used in doughs to reduce mixing time.

health benefits

L-cysteine is an important precursor for antioxidants such as glutathione – a product metabolized in the liver. Glutathione is essential for the breakdown of toxins in the body, such as alcohol. L-cysteine is also the precursor for other important antioxidants that help ward off cancer by decreasing the incidence of cell mutation. Cancer is caused by the replication of genetic mistakes (mutations) that go unnoticed by the cell’s recognition system. In healthy cells, mutations are caught and denatured before replication continues. If mutations are not caught, then the on/off mechanisms that monitor cell formation may be disrupted allowing uncontrolled proliferation of cells into tumors. A healthy cell rich in amino acids such as L-cysteine, has a better chance of sensing and discarding such mutations. L-cysteine benefits can also include improved heart and circulatory system health. Inflammation plays a key role in heart health. The inflammation response causes a cascade of events to bring fluids, proteins and cells to damaged tissues. Some of these substances carried in an inflammatory response are sticky and can get stuck on the walls of arteries. The presence of L-cysteine has been found to directly regulate this adhesion of sticky substances to the walls of arteries and therefore has a positive effect on the health of our hearts. figure 1: L-Cysteine 500mg, 100 Tablets

Side effects

Cysteine has been proposed as a preventative or antidote for some of the negative effects of alcohol, including liver damage and hangover. It counteracts the poisonous effects of acetaldehyde, which is the major by - product of alcohol metabolism and is responsible for most of the negative aftereffects and long - term damage associated with alcohol use (but not the immediate effects of drunkenness). Cysteine supports the next step in metabolism, which turns acetaldehyde into the relatively harmless acetic acid. In a rat study, test animals received an LD50 dose of acetaldehyde. Those that received cysteine had an 80 % survival rate; when both cysteine and thiamine were administered, all animals survived . There is not yet direct evidence for or against its effectiveness in humans who consume alcohol at normal levels. N-Acetylcysteine N - Acetyl - L - cysteine (NAC) is a derivative of cysteine wherein an acetyl group is attached to the nitrogen atom. This compound is sold as a dietary supplement and used as an antidote in cases of acetaminophen overdose, and obsessive compulsive disorders such as trichotillomania.

Definition

ChEBI: An optically active form of cysteine having L-configuration.

Amino acids

L-cysteine, also known as cysteine, is a non-essential amino acid of the human body. Amino acids are protein components and protein is the material basis of life. Ranging from human to microorganism, all consist of protein. Protein is composed of peptides, and peptide chain is composed of amino acids. Different proteins are composed of peptide chains in different order and length. Genes related to heredity are in fact amino acid chains in different orders. L-cysteine is closely related to cysteine, and two molecules of cysteine can form a cysteine. Cysteine is relatively unstable and easy to become cysteine. Cystine can also re-generate cysteine. These two both are sulfur-containing amino acids, which affect the formation of skin and can be used for detoxification. L-cysteine is present in keratin, which is the major protein that makes up nails, toenails, skin and hair. L-cysteine can help the production of collagen, and can maintain the skin's elasticity and texture. It is also related to the protein of digestive enzymes, and cysteine can supply –SH group to many important enzymes, such as succinate dehydrogenase and lactate dehydrogenase. L-cysteine is mainly used in the field of cosmetics, medicine and food. In cosmetics, it can be used for the preparation of perm essence, sunscreen, hair-restoring perfume and other nourishing hair essence. In the field of medicine, it is mainly used for the preparation of methyl cysteine, ethyl cysteine, acetyl cysteine, cysteine methyl ester, cysteine ethyl ester as well as comprehensive amino acid preparations and other drugs. Cysteine can be used as protective agent for radiation damage. In food, L-cysteine can be used as bread fermentation aid (ripening agent), stabilizer of milk powder and fruit juice antioxidants and nutrition of pet food and so on. The above information is edited by andy of Chemicalbook.

Application

Cysteine, mainly the L-enantiomer, is a precursor in the food, pharmaceutical, and personal care industries. One of the largest applications is the production of flavors. For example, the reaction of cysteine with sugars in a Maillard reaction yields meat flavors. Lcysteine is also used as a processing aid for baking. In the field of personal care, cysteine is used for permanent wave applications predominantly in Asia. Again the cysteine is used for breaking up the disulfide bonds in the hair's keratin. Cysteine is a very popular target for site-directed labeling experiments to investigate biomolecular structure and dynamics. Maleimides will selectively attach to cysteine using a covalent Michael addition. Site- directed spin labeling for EPR or paramagnetic relaxation enhanced NMR also uses cysteine extensively. In a 1994 report released by five top cigarette companies, cysteine is one of the 599 additives to cigarettes. Like most cigarette additives, however, its use or purpose is unknown. Its inclusion in cigarettes could offer two benefits: Acting as an expectorant, since smoking increases mucus production in the lungs; and increasing the beneficial antioxidant glutathione (which is diminished in smokers).

Cysteine Metabolism

Cysteine is a sulfur-containing amino acid that constitutes protein. It has an ionized mercapto side chain and is hydrophobic. However, it is unstable in neutral pH or alkaline pH in the air, and its aqueous solution can automatically convert into cysteine . Although cystine does not belong to the list of amino acids composing protein, but in the process of protein conformation, it can generate by oxidizing the SH group of two close cysteine, so many protein molecules in the body contain cystine. The formation of cystine disulfide bond makes the protein conformation more stable. Of course, if the cystine is reduced, it can also produce two molecules of cysteine. The importance of cysteine as a protein component is to give the active protein a free SH group, for example, the active centers of some proteases (papain, bromelain) and glyceraldehyde phosphate dehydrogenase all regard SH group as their function base. The metabolic pathway of cysteine carbon skeleton is mainly to form pyruvate and generate oxaloacetate through carboxylation for gluconeogenesis, so cysteine belongs to the glucogenic amino acid, or to change into acetyl-CoA and come into the tricarboxylic acid cycle for complete oxidization. There may be three ways for cysteine transforming into pyruvate. Non-protein nitrogenous compounds synthesized or part-synthesized by cysteine include taurine, peroxydihydroxyethylamine, coenzyme A and glutathione.

Description

Cysteine (abbreviated as Cys or C) is an α-amino acid with the chemical formula HO2CCH(NH2)CH2SH. It is a semi - essential amino acid, which means that it can be biosynthesized in humans. The thiol side chain in cysteine often participates in enzymatic reactions, serving as a nucleophile. The thiol is susceptible to oxidization to give the disulfide derivative cystine, which serves an important structural role in many proteins. When used as a food additive, it has the E number E920.

Production methods

1. Tin granule reduction method. Dissolve cystine in dilute hydrochloric acid and filtrate. Add tin granules into the filtrate and heat for reflux of 2h. Dilute the reducing solution with water and remove the residual tin particles. Saturate the diluted solution with hydrogen sulfide and filtrate. Wash the residue with a small amount of water and combine the washing liquor with filtrate. Then concentrate the mixture under reduced pressure, cool for crystallization, filtrate and dry to obtain L-cysteine hydrochloride. 2. Electrolysis reduction method. Add distilled water, hydrochloric acid, cystine into the electrolytic tank and dissolve under stirring. Maintain at 50℃ until the electrolysis to the end. Add hydrogen sulphide to pass through the resultant electrolytic solution for several hours and filtrate. Decolorize the filtrate with activated carbon, filtrate and concentrate under reduced pressure. Cool for crystallization, filtrate and then dry to give L-cysteine hydrochloride. 3. Use L-cysteine hydrochloride as raw materials. Neutralize L-cysteine hydrochloride with alkali and obtain L-cysteine after further purification. 4. Heat the hair (or animal hair, feathers) with hydrochloric acid for 6~8h and then hydrolyze. Remove the hydrochloric acid by vacuum distillation. Add activated carbon for decolorization, Filtrate and neutralize with ammonia to obtain L-cystine crude crystals. And then dissolve with ammonia solution for recrystallization. Next dissolve with hydrochloric acid again and perform electrolytic reduction. The resultant electrolytic solution is concentrated, cooled for crystallization and dried to obtain the product.

Safety Profile

Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition fumes of SO and NO.

Purification Methods

Purify it by recrystallisation from H2O (free from metal ions) and dry it in a vacuum. It is soluble in H2O, EtOH, Me2CO, EtOAc, AcOH, *C6H6 and CS2. Acidic solutions can be stored under N2 for a few days without deterioration. [For synthesis and spectra see Greenstein & Winitz Chemistry of the Amino Acids (J. Wiley) Vol 3 p1879 1961, Beilstein 4 III 1618, 4 IV 3144.]

Preparation

By addition of a thiol compound to an unsaturated amino acid derivative; by hydrolysis of proteins in the presence of carbon dioxide; by treating in HCl hydrolysis of proteins in the presence of carbon dioxide; by treating an HCl hydrolysate of hair with CuO2, followed by decomposition of the resulting copper-cysteine complex with hydrogen sulfide; by the addition of thioacetic acid to α-acetamido acrylic acid; by treatment of a keratine HCl hydrolysate with zinc to reduce the cystine present to cysteine; by electrolytic reduction of cystine.

Chemical Properties

White crystalline powder

Biological Functions

The cysteine thiol group is nucleophilic and easily oxidized. The reactivity is enhanced when the thiol is ionized, and cysteine residues in proteins have pKa values close to neutrality, so are often in their reactive thiolate form in the cell. Because of its high reactivity, the thiol group of cysteine has numerous biological functions. Precursor to the antioxidant glutathione Due to the ability of thiols to undergo redox reactions, cysteine has antioxidant properties. Cysteine's antioxidant properties are typically expressed in the tripeptide glutathione, which occurs in humans as well as other organisms. Precursor to iron-sulfur clusters Cysteine is an important source of sulfide in human metabolism. The sulfide in iron-sulfur clusters and in nitrogenase is extracted from cysteine, which is converted to alanine in the process. Metal ion binding Beyond the iron - sulfur proteins, many other metal cofactors in enzymes are bound to the thiolate substituent of cysteinyl residues. Examples include zinc in zinc fingers and alcohol dehydrogenase, copper in the blue copper proteins, iron in cytochrome P450, and nickel in the [NiFe]-hydrogenases . The thiol group also has a high affinity for heavy metals, so that proteins containing cysteine, such as metallothionein, will bind metals such as mercury, lead, and cadmium tightly. Roles in protein structure In the translation of messenger RNA molecules to produce polypeptides, cysteine is coded for by the UGU and UGC codons. Cysteine has traditionally been considered to be a hydrophilic amino acid, based largely on the chemical parallel between its thiol group and the hydroxyl groups in the side-chains of other polar amino acids. However, the cysteine side chain has been shown to stabilize hydrophobic interactions in micelles to a greater degree than the side chain in the non-polar amino acid glycine, and the polar amino acid serine .

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 869, 1986 DOI: 10.1248/cpb.34.869

synthesis

Cysteine can be prepared in three ways: 1, extraction method: process the hair (or feather powder) into cystine, dissolve in hydrochloric acid, and then obtain L-cysteine hydrochloride by electrolysis or the reduction of tin and hydrochloric acid Methods for Extracting Cysteine from Hair 2, synthesis method: the current industrial applications include β-chloroalanine method, α-bromo-methyl acrylate and Degussa method. Use α-chloroacrylic acid methyl ester and thiourea as raw materials to firstly synthesize DL-2-aminothiazoline-4-carboxylic acid and then carry out asymmetric hydrolysis under the action of Pseudomonas aeruginosa enzyme to obtain the product. Use methyl α-bromo-acrylic acid as raw materials to react with methyl thioacetamide and form 2-methyl-thiazoline-4-carboxylic acid methyl ester. The product can be obtained after?? further hydrolysis. α-methyl bromoacrylate method: use chloroacetaldehyde as raw materials to react with sodium bisulfate and form α-hydroxy-β-chloro ethanol sodium sulfonate [2]. [2] and ammonium hydroxide react to form α-amino-β-chlorosulfonate [3]. [3] and sodium hydride react to obtain α-amino-β-chloropropionitrile[4]. After the hydrolysis of [4], β-chloroalanine [5] is generated. Then [5] and ammonium thiosulfate react and hydrolyze to form DL-cysteine precipitation. And L-cysteine can be finally obtained after further desalination. 3, enzymatic method (Ajinomoto method): use α-chloro acrylic acid methyl ester and thiourea as raw materials to firstly synthesize DL-2-aminothiazoline-4-carboxylic acid (DL-ATC). L-cysteine is produced by the asymmetric hydrolysis of DL-ATC in the presence of the three enzymes of thermophilic thiazole pseudomonas bacteria.
InChI:InChI=1/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1

52-90-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (C0515)  L-Cysteine  >98.0%(T) 52-90-4 25g 200.00CNY Detail
TCI America (C0515)  L-Cysteine  >98.0%(T) 52-90-4 100g 635.00CNY Detail
TCI America (C0515)  L-Cysteine  >98.0%(T) 52-90-4 500g 1,880.00CNY Detail
Alfa Aesar (A10435)  L-Cysteine, 98+%    52-90-4 50g 174.0CNY Detail
Alfa Aesar (A10435)  L-Cysteine, 98+%    52-90-4 250g 673.0CNY Detail
Alfa Aesar (A10435)  L-Cysteine, 98+%    52-90-4 1000g 2431.0CNY Detail
Sigma-Aldrich (95437)  L-Cysteine  certified reference material, TraceCERT® 52-90-4 95437-100MG 1,117.35CNY Detail
Aldrich (168149)  L-Cysteine  97% 52-90-4 168149-2.5G 152.10CNY Detail
Aldrich (168149)  L-Cysteine  97% 52-90-4 168149-25G 170.82CNY Detail
Aldrich (168149)  L-Cysteine  97% 52-90-4 168149-100G 596.70CNY Detail
Aldrich (168149)  L-Cysteine  97% 52-90-4 168149-500G 2,359.89CNY Detail
Aldrich (168149)  L-Cysteine  97% 52-90-4 168149-2.5KG 13,162.50CNY Detail

52-90-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name L-Cysteine

1.2 Other means of identification

Product number -
Other names H-CYS-OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52-90-4 SDS

52-90-4Synthetic route

S-(4-methoxybenzyl)-L-cysteine
2544-31-2

S-(4-methoxybenzyl)-L-cysteine

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;100%
With trifluoroacetic acid In dichloromethane at 20℃; Rate constant;
Boc-cysteine(4-Me-Bn)
61925-77-7

Boc-cysteine(4-Me-Bn)

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With phenylthiotrimethylsilane; pertrimethylsilylated Nafion; 3-methyl-phenol; trifluoroacetic acid for 3h;100%
With ethandithiol; methoxybenzene; thallium(III) trifluoroacetate 1.) trifluoroacetic acid, 0 deg c, 60 min; 2.) 40 deg C, 5 h, pH=7.5 adjusted with 5percent NH4OH;
S-(2,4,6-trimethylbenzyl)-L-cysteine
78221-55-3

S-(2,4,6-trimethylbenzyl)-L-cysteine

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With hydrogen fluoride; methoxybenzene at 0℃; for 0.5h; Product distribution; various time, reagents and temperature;100%
S-benzyloxymethylcysteine
123043-33-4

S-benzyloxymethylcysteine

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With silver trifluoromethanesulfonate; methoxybenzene In trifluoroacetic acid Product distribution; other reagents;100%
Z(OMe)-Cys(Ad)-OH*DCHA
103022-01-1

Z(OMe)-Cys(Ad)-OH*DCHA

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;100%
With ethandithiol; methoxybenzene; thallium(III) trifluoroacetate 1.) trifluoroacetic acid, 0 deg c, 60 min; 2.) 40 deg C, 5 h, pH=7.5 adjusted with 5percent NH4OH; Yield given. Multistep reaction;
(2S,4R)-2-methyl-1,3-thiazolidine-2,4-dicarboxylic acid

(2S,4R)-2-methyl-1,3-thiazolidine-2,4-dicarboxylic acid

A

L-Cysteine
52-90-4

L-Cysteine

B

2-acetoacetic acid
541-50-4

2-acetoacetic acid

Conditions
ConditionsYield
With water at 90℃; Column which a srtongly acidic cation exchanger in the H+ form;A n/a
B 99.6%
L-cystine
56-89-3

L-cystine

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With ethandithiol at 40℃; for 5h; pH=7.5 adjusted with 5 percent NH4OH;98.5%
With ammonia; sodium Reduction;90%
With hydrogenchloride; tin man verduennt die Loesung, befreit sie mit H2S vom Zinn, verdunstet zur Trockne, loest den Rueckstand in Alkohol und faellt vorsichtig mit Ammoniak;
N-(Carbo-tert-butoxy)-S-tert-butyl-L-cysteine
56976-06-8

N-(Carbo-tert-butoxy)-S-tert-butyl-L-cysteine

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;97.1%
With ethandithiol; methoxybenzene; thallium(III) trifluoroacetate 1.) trifluoroacetic acid, 0 deg c, 60 min; 2.) 40 deg C, 5 h, pH=7.5 adjusted with 5percent NH4OH; Yield given. Multistep reaction;
L-cystine
56-89-3

L-cystine

A

L-Cysteine
52-90-4

L-Cysteine

B

L-Cysteic acid
498-40-8

L-Cysteic acid

Conditions
ConditionsYield
With hydrogenchloride; sulfuric acid; hydrogen bromide In water at 45℃; electrolysis (graphite sheets, i = 0.5 A/cm2);A 94%
B n/a
With hydrogenchloride; sulfuric acid; hydrogen bromide In water at 45℃; Product distribution; Mechanism; paired electrosynthesis (graphite sheets, i = 0.5 A/cm2);A n/a
B 94%
With hydrogenchloride at 40℃; Electrolysis;
N-t-butoxycarbonyl-S-acetamidomethyl-L-cysteine
19746-37-3

N-t-butoxycarbonyl-S-acetamidomethyl-L-cysteine

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With silver tetrafluoroborate; methoxybenzene In trifluoroacetic acid at 4℃; for 1h;93%
l-cysteine hydrochloride
52-89-1

l-cysteine hydrochloride

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
In acetone for 1.5h; Heating / reflux;92%
With pyridine; ethanol durch Faellung;
With ethanol; ammonia durch Neutralisation;
With sodium hydrogencarbonate In water; dimethyl sulfoxide at 20℃;
Boc-Cys-Merrifield resin

Boc-Cys-Merrifield resin

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With dimethyl ether-poly(hydrogen fluoride) at 0℃; for 1h;91%
L-thioproline
34592-47-7

L-thioproline

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With hydroxylamine hydrochloride83%
With hydroxylamine hydrochloride In methanol reflux, 120 min, ice bath, 60 min;82%
Conditions
ConditionsYield
With porcine kidney D-amino acid oxidase (EC 1.4.3.3.); sodium cyanoborohydride; flavin adenine dinucleotide In phosphate buffer at 37℃;77%
2(R,S)-D-gluco-(1',2',3',4',5'-pentahydroxypentyl)-thiazolidine-4(R)-carboxylic acid
232617-16-2

2(R,S)-D-gluco-(1',2',3',4',5'-pentahydroxypentyl)-thiazolidine-4(R)-carboxylic acid

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With hydroxylamine hydrochloride In methanol; water for 2.5h; Heating;74%
(2R,4R)-2-(D-galacto-1,2,3,4,5-Pentahydroxypentyl)-4-thiazolidincarbonsaeure
57918-01-1, 124650-46-0

(2R,4R)-2-(D-galacto-1,2,3,4,5-Pentahydroxypentyl)-4-thiazolidincarbonsaeure

L-Cysteine
52-90-4

L-Cysteine

Conditions
ConditionsYield
With hydroxylamine hydrochloride In methanol for 3h; Heating;73%
L-cystine
56-89-3

L-cystine

Conditions
ConditionsYield
With 3-bromo-2-(1-hydroxycyclohexyl)[1,2]selenazolo[2,3-a]pyridinium chloride; dihydrogen peroxide In methanol; water at 20℃; for 0.166667h;100%
With dihydrogen peroxide; sodium iodide In water at 25℃; for 1h; Cooling with ice;100%
With bis(4-methoxyphenyl)telluride; rose bengal In water; isopropyl alcohol at 0℃; for 0.833333h; Irradiation;99%
L-Cysteine
52-90-4

L-Cysteine

ethylene dibromide
106-93-4

ethylene dibromide

S,S'-ethanediyl-bis-L-cysteine
14344-49-1

S,S'-ethanediyl-bis-L-cysteine

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water at 70 - 90℃; for 1h;100%
With sodium hydrogencarbonate88%
methanol
67-56-1

methanol

L-Cysteine
52-90-4

L-Cysteine

L-cysteine methyl ester hydrochloride
18598-63-5

L-cysteine methyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride In methanol for 3h; Reflux; Inert atmosphere;100%
With acetyl chloride at 0℃; for 2h; Reflux;96%
Stage #1: methanol With acetyl chloride at 0℃; for 0.0833333h; Inert atmosphere;
Stage #2: L-Cysteine at 20℃; for 36h; Inert atmosphere;
94%
L-Cysteine
52-90-4

L-Cysteine

(R)-2-Amino-3-(4-methoxy-phenylmethanesulfinyl)-propionic acid
73243-09-1

(R)-2-Amino-3-(4-methoxy-phenylmethanesulfinyl)-propionic acid

L-cystine
56-89-3

L-cystine

Conditions
ConditionsYield
With dimethylsulfide; trifluorormethanesulfonic acid In trifluoroacetic acid at 0℃; for 1h;100%
L-Cysteine
52-90-4

L-Cysteine

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

(2RS,4R)-cyclohexylthiazolidine-4-carboxylic acid
56888-62-1

(2RS,4R)-cyclohexylthiazolidine-4-carboxylic acid

Conditions
ConditionsYield
In ethanol at 20℃; for 5h;100%
L-Cysteine
52-90-4

L-Cysteine

tin(ll) chloride

tin(ll) chloride

bis(cysteinato-OS)tin(IV) dihydrochloride dihydrate

bis(cysteinato-OS)tin(IV) dihydrochloride dihydrate

Conditions
ConditionsYield
With water In water aq. mixt. of educts allowed to evap. at room temp. over 3 d; dried in vac. at room temp.; elem. anal.;100%
L-Cysteine
52-90-4

L-Cysteine

2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carbonitrile
251294-64-1

2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carbonitrile

(R)-2-(2-tert-butoxycarbonylaminomethyl-thiazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid
1132667-22-1

(R)-2-(2-tert-butoxycarbonylaminomethyl-thiazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid

Conditions
ConditionsYield
With triethylamine In methanol Reflux;100%
Stage #1: L-Cysteine; 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carbonitrile With triethylamine In methanol Reflux;
Stage #2: With hydrogenchloride In water pH=~ 3 - 4;
100%
Stage #1: L-Cysteine; 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carbonitrile With water; sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
Stage #2: With formic acid; water In N,N-dimethyl-formamide Inert atmosphere;
97%
With triethylamine In methanol at 23℃; for 3h; Reflux;97%
With triethylamine In methanol for 3h; Reflux;97%
L-Cysteine
52-90-4

L-Cysteine

(2S,4R)-N-allyloxycarbonyl-2-cyano-4-methyl-azetidine
1240490-39-4

(2S,4R)-N-allyloxycarbonyl-2-cyano-4-methyl-azetidine

C12H16N2O4S
1240490-42-9

C12H16N2O4S

Conditions
ConditionsYield
In methanol at 70℃; for 15h; pH=7; aq. phosphate buffer; Inert atmosphere;100%
L-Cysteine
52-90-4

L-Cysteine

4-(5-phenyl-3-(selenocyanatomethyl)-1H-pyrazol-1-yl)benzenesulfonamide

4-(5-phenyl-3-(selenocyanatomethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 12h;100%
(4R)-2-sulfanylidene-1,3-thiazolidine-4-carboxylic acid

(4R)-2-sulfanylidene-1,3-thiazolidine-4-carboxylic acid

Conditions
ConditionsYield
With gold; cetyltrimethylammonim bromide; silver nitrate; ascorbic acid at 25℃;100%
L-Cysteine
52-90-4

L-Cysteine

C32H37N7O4S3

C32H37N7O4S3

C35H41N7O6S4

C35H41N7O6S4

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol; aq. phosphate buffer at 70℃; for 4h; pH=5.95;100%
D-xylose
58-86-6

D-xylose

L-Cysteine
52-90-4

L-Cysteine

C8H14NO6S(1-)*Na(1+)

C8H14NO6S(1-)*Na(1+)

Conditions
ConditionsYield
With sodium hydroxide at 80℃; pH=9.5; Temperature; Flow reactor;100%
formaldehyd
50-00-0

formaldehyd

L-Cysteine
52-90-4

L-Cysteine

(R)-thiazolidine-4-carboxylic acid ; sodium-salt
100208-30-8

(R)-thiazolidine-4-carboxylic acid ; sodium-salt

Conditions
ConditionsYield
With sodium hydroxide at 80℃; pH=9.5; Temperature; Flow reactor;100%
L-Cysteine
52-90-4

L-Cysteine

(4R,5aS,7aS,7bR)-5,5a,6,7,7a,7b-hexahydro-7b-hydroxy-4-methyl-indeno[1,7-bc]furan-2(4H)-one
133613-71-5

(4R,5aS,7aS,7bR)-5,5a,6,7,7a,7b-hexahydro-7b-hydroxy-4-methyl-indeno[1,7-bc]furan-2(4H)-one

N-formyl-S-((7bS,3R,4S,5aR,7aR)-7b-hydroxy-4-methyl-2-oxodecahydroindeno[1,7-bc]furan-3-yl)cysteine

N-formyl-S-((7bS,3R,4S,5aR,7aR)-7b-hydroxy-4-methyl-2-oxodecahydroindeno[1,7-bc]furan-3-yl)cysteine

Conditions
ConditionsYield
With triethylamine In d(4)-methanol for 24h;100%
With triethylamine In methanol at 20℃; for 30h;
L-Cysteine
52-90-4

L-Cysteine

2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carbonitrile
251294-64-1

2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carbonitrile

2-[2-[(tert-butoxycarbonyl)methyl]thiazol-4-yl]-4,5-dihydrothiazole-4-carboxylic acid

2-[2-[(tert-butoxycarbonyl)methyl]thiazol-4-yl]-4,5-dihydrothiazole-4-carboxylic acid

Conditions
ConditionsYield
With triethylamine In methanol Reflux;100%
L-Cysteine
52-90-4

L-Cysteine

1,4-benzoquinone-d4
2237-14-1

1,4-benzoquinone-d4

C9H8(2)H3NO4S

C9H8(2)H3NO4S

Conditions
ConditionsYield
In water at 20℃; for 1.16667h; Inert atmosphere;100%
L-Cysteine
52-90-4

L-Cysteine

C6H12N2O4S2*(x)ClH

C6H12N2O4S2*(x)ClH

Conditions
ConditionsYield
With hydrogenchloride; Cumene hydroperoxide; tert-butyl (S)-(tetrahydrotellurophen-3-yl)carbamate In dichloromethane; water at 25℃; Flow reactor;100%
L-Cysteine
52-90-4

L-Cysteine

Methoxycarbonylsulfenyl chloride
26555-40-8

Methoxycarbonylsulfenyl chloride

3-[(methoxycarbonyl)dithio]-L-alanine

3-[(methoxycarbonyl)dithio]-L-alanine

Conditions
ConditionsYield
In 1,4-dioxane at 0 - 20℃; Inert atmosphere;100%
L-Cysteine
52-90-4

L-Cysteine

nicotinic acid riboside 5'-monophosphate

nicotinic acid riboside 5'-monophosphate

bis((R)-1-carboxy-2-mercaptoethan-1-aminium)-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-((phosphonatooxy)methyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate

bis((R)-1-carboxy-2-mercaptoethan-1-aminium)-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-((phosphonatooxy)methyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate

Conditions
ConditionsYield
In water pH=2 - 2.43; Inert atmosphere; Cooling with ice;100%
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