23443-09-6

Basic information

• Product Name: 4-HYDROXYBENZO[H]QUINOLINE
• Synonyms: BENZO[H]QUINOLIN-4-OL;4-HYDROXYBENZO[H]QUINOLINE
• CAS NO: 23443-09-6
• Molecular Formula: C₁₃H₉NO
• Molecular Weight: 195.22
• Mol File: 23443-09-6.mol

Chemical Properties

• Melting Point: 340 °C (decomp)
• Boiling Point: 420.6°Cat760mmHg
• Flash Point: 208.2°C
• Appearance: /
• Density: 1.307g/cm³
• Vapor Pressure: 1.13E-07mmHg at 25°C
• Refractive Index: 1.767
• PKA: 4.55±0.30(Predicted)
• CAS DataBase Reference: 4-HYDROXYBENZO[H]QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYBENZO[H]QUINOLINE(23443-09-6)
• EPA Substance Registry System: 4-HYDROXYBENZO[H]QUINOLINE(23443-09-6)

Safety Data

• Hazardous Substances Data: 23443-09-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXYBENZO[H]QUINOLINE is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds, leveraging its potential biological activities for the development of new drugs.
Used in Anticancer Applications:
In the field of oncology, 4-HYDROXYBENZO[H]QUINOLINE is utilized as a potential anti-cancer agent, targeting a range of cancer types by modulating biological pathways involved in tumor growth and progression.
Used in Antiviral Applications:
4-HYDROXYBENZO[H]QUINOLINE serves as an antiviral agent, potentially inhibiting viral replication and spread, offering a therapeutic approach to combat viral infections.
Used in Anti-inflammatory Applications:
As an anti-inflammatory agent, 4-HYDROXYBENZO[H]QUINOLINE may be employed to reduce inflammation and associated symptoms, providing relief in conditions characterized by inflammatory responses.
Used in Fluorescent Imaging:
Leveraging its fluorescent properties, 4-HYDROXYBENZO[H]QUINOLINE is used in the field of fluorescent imaging, aiding in the visualization of biological processes and structures.
Used as a Fluorescent Probe in Biological Systems:
4-HYDROXYBENZO[H]QUINOLINE functions as a fluorescent probe, enabling researchers to track and study molecular interactions and cellular events within biological systems.

InChI:InChI=1/C13H9NO/c15-12-7-8-14-13-10-4-2-1-3-9(10)5-6-11(12)13/h1-8H,(H,14,15)

Upstream product

• 855283-82-8 4-hydroxybenzo[h]quinoline-2-carboxylic acid 
• 134-32-7 1-amino-naphthalene 
• 131775-94-5 2-[(naphthalen-1-ylamino)methylidene]malonic acid diethyl ester 
• 25063-56-3 2,2-dimethyl-5-[(naphthalen-1-ylamino)methylene]-1,3-dioxane-4,6-dione 
• 855283-81-7 4-hydroxy-benzo[h]quinoline-2-carboxylic acid ethyl ester 
• 71083-13-1 ethyl 4-hydroxybenzo[h]quinoline-3-carboxylate 
• 35957-14-3 4-hydroxy-benzo[h]quinoline-3-carboxylic acid 

Downstream Products

• 68313-48-4 benzo[h]quinolin-4-amine 

Relevant articles and documents

Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High-Temperature and High-Pressure Flow Reactor

Fused pyrimidinone and quinolone derivatives that are of potential interest to pharmaceutical research were synthesized within minutes in up to 96% yield in an automated Phoenix high-temperature and high-pressure continuous flow reactor. Heterocyclic scaffolds that are either hard to synthesize or require multisteps are readily accessible using a common set of reaction conditions. The use of low-boiling solvents along with the high conversions of these reactions allowed for facile workup and isolation. The methods reported herein are highly amenable for fast and efficient heterocycle synthesis as well as compound scale-ups.

Synthesis of novel halogenated 4(1H)-quinolones by thermolysis of arylaminomethylene-1,3-dioxane-4,6-diones

A variety of novel 4(1H)-quinolone derivatives were prepared by thermolysis of aminomethylene Meldrum's acid derivatives. Georg Thieme Verlag Stuttgart.

Thioquinolone compounds which have useful pharmaceutical activity

Disclosed is a thioquinolone derivative which exhibits highly selective antibacterial activity against Helicobacter pylori.